公开(公告)号：US11977067B2

公开(公告)日：2024-05-07

申请号：US18187983

申请日：2023-03-22

申请人： Radius Health, Inc.

发明人： Greg Williams ,  Naveen Palwai ,  David Hanley

IPC分类号： G01N33/15 ,  A61K38/29

CPC分类号： G01N33/15 ,  A61K38/29

摘要： Provided herein are newly discovered methods of analyzing abaloparatide samples for abaloparatide isomers. Additionally, methods of storing and treating with abaloparatide in view of the newly discovered abaloparatide isomers are described.

公开(公告)号：US20240139290A1

公开(公告)日：2024-05-02

申请号：US18405807

申请日：2024-01-05

申请人： Radius Health, Inc.

发明人： Beate Klara Maria Mannstadt ,  Bruce Mitlak

IPC分类号： A61K38/29 ,  A61P9/10

CPC分类号： A61K38/29 ,  A61P9/10

摘要： Disclosed herein is a method of treating cardiomyocyte reperfusion injury associated with an ischemic myocardial event. The method includes administering to a subject in need thereof an effective amount of a abaloparatide to a subject in need thereof prior to performing reperfusion, concurrent with performing reperfusion, or both. Further provided is a method of treating cardiomyocyte reperfusion injury associated with cardiac transplant. The method includes contacting a donor heart with an effective amount of abaloparatide.

公开(公告)号：US11806387B1

公开(公告)日：2023-11-07

申请号：US18320544

申请日：2023-05-19

申请人： Radius Health, Inc.

发明人： Matt Burke ,  Silvio Campagna

IPC分类号： C07K1/06 ,  C07K14/635 ,  A61K38/29 ,  C07K1/04 ,  C07K1/08

CPC分类号： A61K38/29 ,  C07K1/066 ,  C07K14/635 ,  C07K1/04 ,  C07K1/06 ,  C07K1/084

摘要： Disclosed herein is an improved process for preparing abaloparatide. The process generally utilizes solid phase peptide synthesis employing an Fmoc-protection scheme. Incorporating a systematic recoupling step of a glutamine residue (Gln16) has been found to minimize the formation of an undesirable des-Gln16 abaloparatide impurity, which is often obtained in significant quantities in the conventional process.

公开(公告)号：US11680942B2

公开(公告)日：2023-06-20

申请号：US17571312

申请日：2022-01-07

申请人： Radius Health, Inc.

发明人： Heidi K. Chandler

IPC分类号： G01N33/50

CPC分类号： G01N33/5032 ,  G01N2333/635

摘要： The present disclosure is directed to methods (e.g., in vitro methods) for detecting the presence of neutralizing antibodies to PTH or PTHrP analog in a sample. The in vitro method comprises the steps of obtaining a sample from a subject; contacting the sample with a cell; measuring cyclic adenosine monophosphate (cAMP) levels; and detecting the presence of neutralizing antibodies when cAMP levels are reduced relative to a negative control sample without neutralizing antibodies. An in vitro method of detecting the presence of neutralizing antibodies in a sample from a subject treated with Abaloparatide, is also provided. Further provided herein is a kit for carrying out the methods described herein comprising components required to carry out the obtaining, contacting, measuring and detecting steps and instructions for use.

公开(公告)号：US20220378881A1

公开(公告)日：2022-12-01

申请号：US17824256

申请日：2022-05-25

申请人： Radius Health, Inc.

发明人： Elena Nikonova ,  Yamei Wang

IPC分类号： A61K38/29 ,  A61K9/00 ,  A61P19/10

摘要： Disclosed herein is a method for preventing or reducing bone fractures in an overweight subject. The method comprises administering to the subject a therapeutically effective amount of an osteoanabolic agent.

公开(公告)号：US20210389300A1

公开(公告)日：2021-12-16

申请号：US17369163

申请日：2021-07-07

申请人： Radius Health, Inc.

发明人： Heidi K. Chandler

IPC分类号： G01N33/50

摘要： The present disclosure is directed to methods (e.g., in vitro methods) for detecting the presence of neutralizing antibodies to PTH or PTHrP analog in a sample. The in vitro method comprises the steps of obtaining a sample from a subject; contacting the sample with a cell; measuring cyclic adenosine monophosphate (cAMP) levels; and detecting the presence of neutralizing antibodies when cAMP levels are reduced relative to a negative control sample without neutralizing antibodies. An in vitro method of detecting the presence of neutralizing antibodies in a sample from a subject treated with Abaloparatide, is also provided. Further provided herein is a kit for carrying out the methods described herein comprising components required to carry out the obtaining, contacting, measuring and detecting steps and instructions for use.

公开(公告)号：US20200061160A1

公开(公告)日：2020-02-27

申请号：US16566499

申请日：2019-09-10

申请人： Radius Health, Inc.

发明人： Gary Hattersley

IPC分类号： A61K38/29 ,  A61K45/06 ,  A61K9/00

摘要： Disclosed herein are PTHrP or analogues thereof, such as abaloparatide, for preventing or reducing bone fractures in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to prevent or reduce bone fractures. Also disclosed are PTHrP or analogues thereof, such as abaloparatide, for increasing BMD and/or TBS in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to increase BMD and/or TBS.

公开(公告)号：US09555014B2

公开(公告)日：2017-01-31

申请号：US14281475

申请日：2014-05-19

申请人： Radius Health, Inc.

发明人： Louis O'Dea ,  C. Richard Lyttle ,  Jonathan Guerriero

IPC分类号： A61K31/135 ,  A01N33/02 ,  A61K31/137 ,  A61K9/48

CPC分类号： A61K31/137 ,  A61K9/485 ,  A61K9/4866

摘要： This invention relates to clinically useful therapeutic regimens comprising the administration of (R)-6-(2-(ethyl(4-(2-(ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol.

摘要翻译： 本发明涉及临床有用的治疗方案，其包括施用（R）-6-（2-（乙基（4-（2-（乙基氨基）乙基）苄基）氨基）-4-甲氧基苯基）-5,6,7， 8-四氢萘-2-醇。

公开(公告)号：US20140046293A1

公开(公告)日：2014-02-13

申请号：US13791360

申请日：2013-03-08

申请人： Radius Health, Inc. ,  3M Innovative Properties Company, a wholly owned subsidiary of 3M Company

发明人： Gary Hattersley ,  Kris J. Hansen ,  Amy S. Determan ,  Ying Zhang

IPC分类号： A61K38/29 ,  A61K9/00

摘要： The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.

摘要翻译： 本发明提供了与皮内递送PTHrP和PTHrP类似物，特别是[Glu22,25，Leu23,28,31，Aib29，Lys26,30] hPTHrP（1-34）NH2相关的组合物，装置，方法和方法。

公开(公告)号：US20120004270A1

公开(公告)日：2012-01-05

申请号：US13175306

申请日：2011-07-01

申请人： Chris P. Miller

发明人： Chris P. Miller

IPC分类号： A61K31/4245 ,  C12N5/071 ,  G01N33/53 ,  A61P25/28 ,  A61P21/00 ,  A61P15/00 ,  A61P15/08 ,  A61P15/10 ,  A61P15/02 ,  A61P25/24 ,  A61P35/00 ,  A61P9/10 ,  A61P3/04 ,  A61P1/00 ,  A61P19/10 ,  A61P17/00 ,  C07D271/10

CPC分类号： A61K31/4245 ,  G01N2333/723 ,  G01N2500/10

摘要： This invention provides compounds as described herein or pharmaceutically acceptable salte thereof, pharmaceutical compositions comprising a compound as described herein or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor using the compounds or compositions described herein, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) using the compounds and compositions described herein and processes for making compounds described herein and intermediates useful in the preparation of same.

摘要翻译： 本发明提供本文所述的化合物或其药学上可接受的盐，包含本文所述的化合物或其药学上可接受的盐和药学上可接受的赋形剂的药物组合物，使用本文所述的化合物或组合物调节雄激素受体的方法，治疗方法 使用本文所述的化合物和组合物以及制备本文所述化合物的方法和中间体的方法由雄激素受体调节剂（例如肌肉减少症，前列腺癌，避孕，2型糖尿病相关疾病或疾病，贫血，抑郁症和肾脏疾病）有益治疗的疾病 在制备中有用。