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    Pulsatile flow atmospheric real time ionization
    1.
    发明授权
    Pulsatile flow atmospheric real time ionization 有权

    公开(公告)号：US11615951B2

    公开(公告)日：2023-03-28

    申请号：US17708736

    申请日：2022-03-30

    申请人： IonSense, Inc.

    发明人： Scott Oro ,  Brian Musselman

    IPC分类号： H01J49/16 ,  H01J49/14 ,  H01J49/42

    摘要： This disclosure presents inventions for ionization, for example, for use in mass spectrometer devices and methods. In an embodiment, a device is provided for introduction of pulses of a first carrier gas into an ionization chamber and introduction of a second carrier gas into the ionization chamber. Electrodes in the chamber ionize the carrier gas and direct the ionized gas toward a sample for analysis. The second carrier gas can either assist in washing out the first carrier gas or may become ionized along with the first carrier gas to improve ionization of an analyte. In an embodiment, a method for producing ionized carrier gasses is provided.

    PULSATILE FLOW ATMOSPHERIC REAL TIME IONIZATION
    2.
    发明申请
    PULSATILE FLOW ATMOSPHERIC REAL TIME IONIZATION 有权

    公开(公告)号：US20220013347A1

    公开(公告)日：2022-01-13

    申请号：US17266246

    申请日：2020-10-26

    申请人： IonSense Inc..

    发明人： Scott Oro ,  Brian D Musselman

    IPC分类号： H01J49/16 ,  H01J49/14 ,  H01J49/42

    摘要： In an embodiment of the present ambient ionization experiment, the abundance of background chemicals relative to ions of interest is decreased by pulsing the carrier gas used to generate the excited species directed at the sample. The excited species are stepwise directed at the sample reducing the overall abundance of background chemicals introduced into the ionizing region. In an embodiment of the present ambient ionization experiment, the combination of stepping the sample in front of the excited species and pulsing the carrier gas used to generate the excited species increases the sensitivity of detection.

    Apparatus and method for generating chemical signatures using differential desorption
    6.
    发明授权
    Apparatus and method for generating chemical signatures using differential desorption 有权
    使用差分解吸法生成化学特征的装置和方法

    公开(公告)号：US09337007B2

    公开(公告)日：2016-05-10

    申请号：US14738899

    申请日：2015-06-14

    申请人： IONSENSE INC.

    发明人： Brian D Musselman

    IPC分类号： H01J49/00 ,  H01J49/16

    CPC分类号： H01J49/165 ,  G01N1/4022 ,  G01N2001/028 ,  G01N2030/009 ,  G01N2030/062 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/16

    摘要： The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

    摘要翻译： 本发明涉及一种生成分析物混合物的化学特征的方法和装置。 本发明涉及使用SPME表面吸收和吸附分析物混合物中的一种或两种。 在本发明的一个实施方案中，然后将表面暴露于用适当的空间分辨率选择的不同温度的离子化物质以解吸分析物混合物的化学特征。

    APPARATUS AND METHOD FOR THERMAL ASSISTED DESORPTION IONIZATION SYSTEMS
    8.
    发明申请
    APPARATUS AND METHOD FOR THERMAL ASSISTED DESORPTION IONIZATION SYSTEMS 审中-公开
    用于热辅助离子浓度系统的装置和方法

    公开(公告)号：US20150206730A1

    公开(公告)日：2015-07-23

    申请号：US14589687

    申请日：2015-01-05

    申请人： IONSENSE INC.

    发明人： Jordan Krechmer ,  Brian D. Musselman

    IPC分类号： H01J49/04 ,  H01J49/10 ,  G01N27/62 ,  H01J49/24

    CPC分类号： H01J49/049 ,  G01N27/622 ,  G01N27/626 ,  G01N27/64 ,  H01J27/26 ,  H01J49/004 ,  H01J49/04 ,  H01J49/0431 ,  H01J49/10 ,  H01J49/126 ,  H01J49/14 ,  H01J49/24 ,  Y10T436/24

    摘要： The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.

    摘要翻译： 本发明涉及一种使用热解析分析物以允许分析物分子解吸的方法和装置，其中解吸的分析物分子与环境温度电离物质电离。 在本发明的各种实施方案中，电流通过其上存在分析物分子的网。 电流加热网格并导致分析物分子的解吸，然后分析物分子与气相亚稳态的中性分子或原子相互作用以形成分析物分子特征的分析物离子。

    Sampling of confined spaces
    9.
    发明授权
    Sampling of confined spaces 有权
    密闭空间抽样

    公开(公告)号：US08207497B2

    公开(公告)日：2012-06-26

    申请号：US12776034

    申请日：2010-05-07

    申请人： Brian D. Musselman

    发明人： Brian D. Musselman

    IPC分类号： H01J49/26 ,  H01J49/00 ,  B01D59/44

    CPC分类号： H01J49/10 ,  G01N1/2214 ,  G01N27/62 ,  H01J49/0027 ,  H01J49/0409

    摘要： In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container.

    摘要翻译： 在本发明的各种实施例中，可以以适当的时间间隔来监视货物集装箱，以确定货物在集装箱中没有运送受控物质。 监测利用从大气分析仪产生的反应物质电离存在于容器中的分析物分子，然后通过合适的光谱系统进行分析。 在本发明的一个实施方案中，可以使用吸附剂表面来吸收，吸附或冷凝容器内的分析物分子，然后可以用反应性物质询问吸附剂表面以产生容器内容物特征的分析物质。

    Sampling system for containment and transfer of ions into a spectroscopy system
    10.
    发明授权
    Sampling system for containment and transfer of ions into a spectroscopy system 有权
    用于将离子收集和转移到光谱系统中的采样系统

    公开(公告)号：US07928364B2

    公开(公告)日：2011-04-19

    申请号：US11872666

    申请日：2007-10-15

    申请人： Brian D. Musselman

    发明人： Brian D. Musselman

    IPC分类号： H01J49/04

    CPC分类号： H01J49/0404 ,  H01J49/0418 ,  H01J49/0459 ,  H01J49/06

    摘要： The invention provides for efficient collection of analyte ions and neutral molecules from surfaces for their subsequent analysis with spectrometry. In an embodiment of the invention, a ‘multiple desorption ionization source’ includes a tube which can contain ions for subsequent sampling within a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment, electrostatic fields are used to direct ions a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, either narrow inside diameter capillary tubes or wide diameter tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the invention, a dopant is introduced into a tube to analyze the sample. In an embodiment of the invention, a plurality of ionization sources is used to analyze the sample.

    摘要翻译： 本发明提供了从表面有效收集分析物离子和中性分子用于随后的分析。 在本发明的一个实施方案中，“多重解吸电离源”包括管，其可以包含离子，用于在大气压力附近或接近大气压力下的解吸电离的定义的空间分辨率中进行后续取样。 在一个实施例中，使用静电场来引导离子定位在正被分析的样品表面附近的多个管。 在本发明的一个实施例中，窄内径毛细管或宽直径管可以与真空入口组合使用，以将离子和中性粒子吸入光谱仪进行分析。 在本发明的一个实施方案中，将掺杂剂引入管中以分析样品。 在本发明的一个实施例中，使用多个电离源来分析样品。