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    Process to form a tablet and apparatus suitable for applying this process
    1.
    发明授权
    Process to form a tablet and apparatus suitable for applying this process 有权
    形成适用于该方法的片剂和装置的方法

    公开(公告)号：US09119794B2

    公开(公告)日：2015-09-01

    申请号：US13266510

    申请日：2010-04-28

    申请人： Hans Almer Middelbeek ,  Jozefus A. C. Smit

    发明人： Hans Almer Middelbeek ,  Jozefus A. C. Smit

    IPC分类号： B29C39/38 ,  B65D85/00 ,  B28B7/42 ,  A61K9/20 ,  A61J3/10 ,  A61J7/00 ,  A61K9/00

    CPC分类号： A61K9/2095 ,  A61J3/10 ,  A61J7/0007 ,  A61K9/0056

    摘要： The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.

    摘要翻译： 本发明涉及一种制备含有药物的快速崩解片剂（30）的方法，包括以下步骤：提供包含药物的流体制剂，提供其中形成有至少一种 空腔，（101）将固体元件（100）冷却至低于制剂的冷冻温度的温度，用流体制剂填充空腔，在存在于空腔（101）中时固化制剂以形成固体颗粒，其包含药物 物质，而不主动地塑造颗粒的整个表面，将颗粒从空腔中取出并在真空中干燥沉淀物以获得片剂。 本发明还涉及用于执行这种方法的系统和包含所得到的片剂的包装。

    Method for continuously culturing Ehrlichia canis
    2.
    发明授权
    Method for continuously culturing Ehrlichia canis 有权
    连续培养伊朗杆菌的方法

    公开(公告)号：US09051557B2

    公开(公告)日：2015-06-09

    申请号：US12674114

    申请日：2008-09-11

    申请人： Jane Kwun-Lai Battles ,  Kimberly D. Proudfoot ,  Brenda L. Meding ,  Patrick G. Funk ,  R. Monty Warthen ,  F. Randall Bethke ,  Eric A. Ellis ,  Amy Y. Purse

    发明人： Jane Kwun-Lai Battles ,  Kimberly D. Proudfoot ,  Brenda L. Meding ,  Patrick G. Funk ,  R. Monty Warthen ,  F. Randall Bethke ,  Eric A. Ellis ,  Amy Y. Purse

    IPC分类号： C12N1/20

    CPC分类号： C12N1/20

    摘要： The present invention relates to a method of culturing bacterial organisms belonging to the family Anaplasmataceae in mammalian embryonic or fetal cells. In particular, the present invention is directed to growth of bacterial organisms belonging to the family Anaplasmataceae including organisms belonging to the Anaplasma, Ehrlichia and Neorickettsia genera. The bacterial organisms may be cultured in mammalian embryonic or fetal host cells including feline embryonic host cells. Bacterial material cultured according to the methods described herein may be used as the basis for vaccines against diseases associated with the Anaplasmataceae bacteria, or as the basis for diagnostic applications useful for diagnosing diseases associated with the Anaplasmataceae bacteria.

    摘要翻译： 本发明涉及一种在哺乳动物胚胎或胎儿细胞中培养属于Anaplasmataceae的细菌生物的方法。 特别地，本发明涉及属于Anaplasmataceae的细菌生物，包括属于Anaplasma，Ehrlichia和Neorickettsia属的生物。 细菌生物可以在哺乳动物胚胎或胎儿宿主细胞中培养，包括猫胚胎宿主细胞。 根据本文所述的方法培养的细菌物质可以用作针对与阿扁丝藓科细菌相关的疾病的疫苗的基础，或者可用作用于诊断与阿扁ace科细菌有关的疾病的诊断应用的基础。

    Method to grow Lawsonia intracellularis bacteria in persistently infected McCoy cells
    8.
    发明授权
    Method to grow Lawsonia intracellularis bacteria in persistently infected McCoy cells 有权
    在持续感染的McCoy细胞中培养细胞内劳森氏菌细菌的方法

    公开(公告)号：US08530223B2

    公开(公告)日：2013-09-10

    申请号：US13505667

    申请日：2010-11-08

    申请人： Yvonne Maria Johanna Corina Biermann ,  Carla Christina Schrier ,  Petrus Theodorus Johannes Andries Gelder van ,  Bram Verdellen ,  Barry Lijsdonk

    发明人： Yvonne Maria Johanna Corina Biermann ,  Carla Christina Schrier ,  Petrus Theodorus Johannes Andries Gelder van ,  Bram Verdellen ,  Barry Lijsdonk

    IPC分类号： C12N1/20 ,  A61P31/04

    CPC分类号： C12N1/20 ,  C12N1/00

    摘要： The present invention pertains to a method to obtain McCoy cells persistently infected with Lawsonia intracellularis bacteria, comprising infecting McCoy cells with Lawsonia intracellularis bacteria, growing the infected McCoy cells in a suitable medium at an oxygen concentration less than 18% to arrive at a culture of McCoy cells infected with Lawsonia intracellularis bacteria, passing at least a part of the said culture to fresh medium, and without adding uninfected McCoy cells to the medium, growing the infected McCoy cells contained in the said at least part in the fresh medium at an oxygen concentration less than 18%, to obtain the persistently infected McCoy cells. The invention also pertains to the use of such persistently infected cells to grow and obtain these bacteria in purified form.

    摘要翻译： 本发明涉及一种获得持续感染细胞内劳森氏菌细菌的McCoy细胞的方法，包括用细胞内劳森氏菌感染McCoy细胞，将感染的McCoy细胞在氧浓度小于18％的合适培养基中培养以获得 McCoy细胞感染细胞内劳森氏菌细菌，将至少一部分所述培养物转移到新鲜培养基中，并且不将未感染的McCoy细胞添加到培养基中，在含氧的新鲜培养基中培养所述至少部分所述至少部分的感染的McCoy细胞 浓度小于18％，以获得持续感染的McCoy细胞。 本发明还涉及使用这种持续感染的细胞生长并获得纯化形式的这些细菌。

    Macrolide synthesis process and solid-state forms
    9.
    发明授权
    Macrolide synthesis process and solid-state forms 有权
    大环内酯合成过程和固态形式

    公开(公告)号：US08518900B2

    公开(公告)日：2013-08-27

    申请号：US13359327

    申请日：2012-01-26

    申请人： Ralf Warrass ,  Fritz Blatter ,  Meinrad Brenner ,  Guixan Hu ,  Timo Rager

    发明人： Ralf Warrass ,  Fritz Blatter ,  Meinrad Brenner ,  Guixan Hu ,  Timo Rager

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, among other uses, may be used to make macrolides. Also described are solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.

    摘要翻译： 描述了制备大环内酯类的方法，特别是制备任选取代的20,23-二哌啶基-5-O-碳霉糖基 - 太乐内酯及其衍生物的方法，以及大环内酯类制备药物的用途，使用大环内酯类的治疗方法 以及用于制造中间体的方法，除了其它用途之外，可以使用它们来制备大环内酯类。 还描述了20,23-二哌啶基-5-O-碳霉糖基 - 太乐内酯的溶剂化和非溶剂化结晶形式，以及制备这种结晶形式的方法，包含（或衍生自）这种结晶形式的药物，制备药物的方法 包括（或衍生自）这种结晶形式，使用这种结晶形式的处理方法，以及包含这种结晶形式的试剂盒。