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公开(公告)号：US07202020B2
公开(公告)日：2007-04-10
申请号：US10865292
申请日：2004-06-09
CPC分类号： B01J3/04 , A01N1/021 , A01N1/0226 , A01N1/0231 , A01N1/0252 , A01N1/0257 , A01N1/0289 , B01J3/03
摘要： A platelet composition suitable for direct transfusion into a patient is provided. The platelet composition includes a preservation medium comprising plasma and a gel-forming material in a concentration relative to the plasma such that the medium is in a sufficiently fluent state at about 37° C. to allow platelets to move within the medium and is in a sufficiently gelatinous state at about 5° C. to substantially prevent platelets from moving freely within the medium; and platelets.
摘要翻译： 提供适于直接输入患者的血小板组合物。 血小板组合物包含保存介质，其包含相对于血浆浓度的等离子体和凝胶形成材料，使得介质在约37℃下处于充分流动状态，以允许血小板在培养基内移动，并且处于 在约5℃下充分凝胶状态，以基本上防止血小板在培养基内自由移动; 和血小板。
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公开(公告)号：US07029839B2
公开(公告)日：2006-04-18
申请号：US10830863
申请日：2004-04-22
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and washing solutions at least containing polyvinylpyrrolidone, a calcium channel blocker, a nucleoside, potassium chloride, polyethylene glycol, at least one amino acid, and a steroid to a temperature of 2° to 4° C. and/or of 0° to 2° C., harvesting a donor organ, perfusing it with one or more of the solution, immersing it in one or more of the solutions and storing it at a temperature above 0° C. or at a temperatures below 0° C. The cryopreservation solution also contains cryopreservative agents. Preserved organs may be transplanted directly from refrigeration storage or from freezer storage by cooling the washing refrigeration preservation solutions to 2° to 4° C., perfusing the organ with washing solution and then preservation solution, and transplanting it.
摘要翻译： 一种保存，储存和移植哺乳动物供体器官的方法。 该方法包括将至少含有聚乙烯吡咯烷酮，钙通道阻断剂，核苷，氯化钾，聚乙二醇，至少一种氨基酸和类固醇的冷冻保存，预冷冻保存，冷冻保存和洗涤溶液冷却至温度 2°至4℃和/或0°至2℃，收获供体器官，用一种或多种溶液灌注，将其浸入一种或多种溶液中并将其储存在温度 0℃以上或低于0℃的温度。冷冻保存溶液还含有冷冻保存剂。 保存的器官可以直接从制冷储存器或冷冻储存器中冷却，将洗涤制冷保存溶液冷却至2°至4℃，用洗涤液灌注器官，然后将其移植。
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公开(公告)号：US20050019917A1
公开(公告)日：2005-01-27
申请号：US10830863
申请日：2004-04-22
IPC分类号： A01N1/00 , A01N1/02 , A61B20060101 , C12N5/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and washing solutions at least containing polyvinylpyrrolidone, a calcium channel blocker, a nucleoside, potassium chloride, polyethylene glycol, at least one amino acid, and a steroid to a temperature of 2° to 4° C. and/or of 0° to 2° C., harvesting a donor organ, perfusing it with one or more of the solution, immersing it in one or more of the solutions and storing it at a temperature above 0° C. or at a temperatures below 0° C. The cryopreservation solution also contains cryopreservative agents. Preserved organs may be transplanted directly from refrigeration storage or from freezer storage by cooling the washing refrigeration preservation solutions to 2° to 4° C., perfusing the organ with washing solution and then preservation solution, and transplanting it.
摘要翻译： 一种保存，储存和移植哺乳动物供体器官的方法。 该方法包括将至少含有聚乙烯吡咯烷酮，钙通道阻断剂，核苷，氯化钾，聚乙二醇，至少一种氨基酸和类固醇的冷冻保存，预冷冻保存，冷冻保存和洗涤溶液冷却至温度 2°至4℃和/或0°至2℃，收获供体器官，用一种或多种溶液灌注，将其浸入一种或多种溶液中并将其储存在温度 0℃以上或低于0℃的温度。冷冻保存溶液还含有冷冻保存剂。 保存的器官可以直接从制冷储存器或冷冻储存器中冷却，将洗涤制冷保存溶液冷却至2°至4℃，用洗涤液灌注器官，然后将其移植。
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公开(公告)号：US07083910B2
公开(公告)日：2006-08-01
申请号：US10911978
申请日：2004-08-04
申请人： David Lucas , Raleigh Carmen
发明人： David Lucas , Raleigh Carmen
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0221
摘要： Methods and compositions for preserving blood platelet suspensions which can be stored and preserved for extended periods of time are provided herein. The methods and compositions employ a mixture comprising blood platelets and one or more citrate salts. Such blood platelet mixtures may be cooled either rapidly or slowly and stored for several days prior to use in patients.
摘要翻译： 本文提供了可以长期储存和保存的血小板悬浮液的保存方法和组合物。 方法和组合物使用包含血小板和一种或多种柠檬酸盐的混合物。 这样的血小板混合物可以快速或缓慢地冷却，并在用于患者之前储存数天。
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公开(公告)号：US20060121438A1
公开(公告)日：2006-06-08
申请号：US11276183
申请日：2006-02-16
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and washing solutions at least containing polyvinylpyrrolidone, a calcium channel blocker, a nucleoside, potassium chloride, polyethylene glycol, at least one amino acid, and a steroid to a temperature of 2° to 4° C. and/or of 0° to 2° C., harvesting a donor organ, perfusing it with one or more of the solution, immersing it in one or more of the solutions and storing it at a temperature above 0° C. or at a temperatures below 0° C. The cryopreservation solution also contains cryopreservative agents. Preserved organs may be transplanted directly from refrigeration storage or from freezer storage by cooling the washing refrigeration preservation solutions to 2° to 4° C., perfusing the organ with washing solution and then preservation solution, and transplanting it.
摘要翻译： 一种保存，储存和移植哺乳动物供体器官的方法。 该方法包括将至少含有聚乙烯吡咯烷酮，钙通道阻断剂，核苷，氯化钾，聚乙二醇，至少一种氨基酸和类固醇的冷冻保存，预冷冻保存，冷冻保存和洗涤溶液冷却至温度 2°至4℃和/或0°至2℃，收获供体器官，用一种或多种溶液灌注，将其浸入一种或多种溶液中并将其储存在温度 0℃以上或低于0℃的温度。冷冻保存溶液还含有冷冻保存剂。 保存的器官可以直接从制冷储存器或冷冻储存器中冷却，将洗涤制冷保存溶液冷却至2°至4℃，用洗涤液灌注器官，然后将其移植。
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