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公开(公告)号：US20230125380A1
公开(公告)日：2023-04-27
申请号：US17771777
申请日：2020-11-05
申请人： Dermira, Inc.
发明人： Jamie L. Harden , Hans E.J. Hofland
IPC分类号： A61K31/4439 , A61K9/00 , A61P29/00 , A61P17/00
摘要： This disclosure is directed to use of IRAK4 inhibitors in the treatment of dermatological disorders or conditions characterized by inflammation This disclosure is also directed to pharmaceutical compositions comprising an IRAK4 inhibitor and a pharmaceutically acceptable carrier for topical administration
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公开(公告)号：US09975867B2
公开(公告)日：2018-05-22
申请号：US15015569
申请日：2016-02-04
申请人： Dermira Inc.
IPC分类号： C07D307/68
CPC分类号： C07D307/68
摘要： Disclosed herein are processes for forming 2-furoic acid derivatives represented by Formula (I):
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公开(公告)号：US09006461B2
公开(公告)日：2015-04-14
申请号：US14024480
申请日：2013-09-11
申请人： Dermira, Inc.
发明人： John Allan Statler , Anthony Adrian Shaw , Delphine Caroline Imbert , Jennifer Leigh Nelson , Patricia Andres , Lisa Lynn McQueen , Stephan Xander Mattheus Boerrigter
IPC分类号： C07D207/12 , C07C309/30
CPC分类号： C07D207/12 , C07C309/30
摘要： Salts of glycopyrrolate, including solid forms thereof are herein disclosed. Methods of making glycopyrrolate salts and methods of treating hyperhidrosis with salts of glycopyrrolate are disclosed.
摘要翻译： 本文公开了格隆溴铵盐，包括其固体形式的盐。 公开了制备格隆溴铵盐的方法和用格隆溴铵盐处理多汗症的方法。
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公开(公告)号：US20140371290A1
公开(公告)日：2014-12-18
申请号：US14473537
申请日：2014-08-29
申请人： DERMIRA, INC.
发明人： John Allan STATLER , Anthony Adrian SHAW , Delphine Caroline IMBERT , Jennifer Leigh NELSON , Patricia ANDRES , Lisa Lynn McQUEEN , Stephan Xander Mattheus BOERRIGTER , Jon Gordon SELBO , Mark Christopher ANDRES
IPC分类号： C07C309/30 , C07D207/12
CPC分类号： A61K31/40 , A61K9/0014 , A61K9/08 , A61K9/145 , A61K9/146 , A61K31/10 , A61L15/24 , A61L15/44 , C07C309/30 , C07D207/12 , A61K2300/00 , C08L23/12
摘要： Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed.
摘要翻译： 公开了格隆溴铵的盐，包括固体形式和制剂如其局部物质。 公开了制备格隆溴铵盐的方法，包括诸如其局部的制剂，以及用格隆溴铵盐处理多汗症的方法，以及其制剂如局部用药。
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公开(公告)号：US20140242122A1
公开(公告)日：2014-08-28
申请号：US14024484
申请日：2013-09-11
申请人： Dermira, Inc.
发明人： John Allan STATLER , Anthony Adrian SHAW , Delphine Caroline IMBERT , Jennifer Leigh NELSON , Patricia ANDRES , Lisa Lynn McQUEEN , Stephan Xander Mattheus BOERRIGTER
IPC分类号： C07D207/12 , C07C309/30
CPC分类号： C07D207/12 , C07C309/30
摘要： Salts of glycopyrrolate, including solid forms thereof are herein disclosed. Methods of making glycopyrrolate salts and methods of treating hyperhidrosis with salts of glycopyrrolate are disclosed.
摘要翻译： 本文公开了格隆溴铵盐，包括其固体形式的盐。 公开了制备格隆溴铵盐的方法和用格隆溴铵盐处理多汗症的方法。
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公开(公告)号：US20230321124A1
公开(公告)日：2023-10-12
申请号：US18007940
申请日：2021-06-29
申请人： DERMIRA, INC.
发明人： Jamie L. Harden , Delphine Imbert
IPC分类号： A61K31/695 , A61K47/10 , A61K47/22 , A61K47/14 , A61K47/38 , A61K47/26 , A61K47/12 , A61K9/06 , A61K47/32 , A61K9/00
CPC分类号： A61K31/695 , A61K47/10 , A61K47/22 , A61K47/14 , A61K47/38 , A61K47/26 , A61K47/12 , A61K9/06 , A61K47/32 , A61K9/0014
摘要： The present disclosure is directed to use of RORγt inhibitors in the treatment of autoimmune disorders, e.g., autoimmune disorders of the skin. This invention is also directed to pharmaceutical compositions comprising an RORγt inhibitor and a pharmaceutically acceptable carrier for topical administration.
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公开(公告)号：US20230027929A1
公开(公告)日：2023-01-26
申请号：US17773404
申请日：2020-11-05
申请人： Dermira, Inc.
发明人： Ferda Cevikbas , Christopher Pearson , Donnya Etheridge , Laura Gleave , Mark Duggan , Nina Connelly Ursinyova , Vasileios Roumpelakis
IPC分类号： C07D213/75 , A61K31/4412 , A61K31/4433 , C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4439 , C07D401/12 , A61K31/4427 , C07D413/04 , C07D241/20 , A61K31/4965 , A61K31/436 , C07D498/04 , C07D239/47 , A61K31/513 , A61K31/506 , C07D403/12 , C07D403/04 , C07D401/06 , A61K9/00
摘要： The present disclosure is directed to use of MrgprX2 antagonists in the treatment of inflammatory disorders, e.g., inflammatory disorders of the skin. This invention is also directed to pharmaceutical compositions comprising a MrgprX2 antagonist and a pharmaceutically or orally acceptable carrier for administration.
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公开(公告)号：US09745277B2
公开(公告)日：2017-08-29
申请号：US15284319
申请日：2016-10-03
申请人： Dermira Inc.
IPC分类号： A61K31/55 , C07D307/68 , C07D307/56
CPC分类号： C07D307/68 , C07D307/56
摘要： Disclosed herein are processes for forming 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-tetradecyloxy)furan-2-carboxylate:
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公开(公告)号：US09610278B2
公开(公告)日：2017-04-04
申请号：US14989995
申请日：2016-01-07
申请人： Dermira, Inc.
发明人： John Allan Statler , Anthony Adrian Shaw , Delphine Caroline Imbert , Jennifer Leigh Nelson , Patricia Andres , Lisa Lynn McQueen , Stephan Xander Mattheus Boerrigter , Jon Gordon Selbo , Mark Christopher Andres
IPC分类号： C07D207/12 , A61K31/40
CPC分类号： A61K31/40 , A61K9/0014 , A61K9/08 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/34 , C07D207/12
摘要： Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed.
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公开(公告)号：US20160113902A1
公开(公告)日：2016-04-28
申请号：US14989995
申请日：2016-01-07
申请人： Dermira, Inc.
发明人： John Allan STATLER , Anthony Adrian SHAW , Delphine Caroline IMBERT , Jennifer Leigh NELSON , Patricia ANDRES , Lisa Lynn MCQUEEN , Stephan Xander Mattheus BOERRIGTER , Jon Gordon SELBO , Mark Christopher ANDRES
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , A61K9/0014 , A61K9/08 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/34 , C07D207/12
摘要： Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed.
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