公开(公告)号：US20210128735A1

公开(公告)日：2021-05-06

申请号：US17054050

申请日：2019-05-08

Applicant: CIS PHARMA AG

Inventor： Christian Geraths ,  Christophe Thommen ,  Michael Hackebeil ,  Davide Panighetti ,  Hans Hitz

IPC: A61K47/58 ,  C08F2/38 ,  A61K45/06

Abstract: The present disclosure relates to the delivery of active agents, e.g., drug substances, using as carriers for their delivery biocompatible copolymers comprising side chain-linked amino acids having active agents bound to their alpha-amino and/or alpha-carboxyl groups, either directly or via linker molecules. The active agent-containing copolymers can be functionalized to contain cell type- or tissue type-specific targeting moieties.

公开(公告)号：US20140039386A1

公开(公告)日：2014-02-06

申请号：US13261707

申请日：2012-02-14

Applicant: Rolf Schäfer

Inventor： Rolf Schäfer

IPC: A61J1/20 ,  A61M5/315

CPC classification number: A61J1/2096 ,  A61J1/00 ,  A61J1/20 ,  A61J1/2089 ,  A61K9/0048 ,  A61K31/546 ,  A61M5/00 ,  A61M5/178 ,  A61M5/19 ,  A61M5/2448 ,  A61M5/31596 ,  F16D43/18

Abstract: The present invention relates to safety delivery systems for intracameral administration of an appropriate dose of cefuroxime subsequent to cataract and other eye surgery. A preferred embodiment of an cefuroxime safety delivery system according to the invention comprises (a) a perforable sterile vial sterile-filled with a measured amount of cefuroxime, (b) a reconstitution syringe with a male luer fitting sterile-filled with 0.1 ml of isotonic salt solution per mg cefuroxime in the perforable vial and a vial adapter with a female luer fitting or one or more needles with female luer fitting, and (c) one or more sterilized delivery syringes with male luer fitting, each delivery syringe being capable of holding at least 0.1 ml of ejectable liquid and containing a marking indicating a fill volume of 0.1 ml of ejectable liquid.

Abstract translation: 本发明涉及用于在白内障和其它眼睛手术之后的适当剂量的头孢呋辛的腔内施用的安全递送系统。 根据本发明的头孢呋辛安全递送系统的优选实施方案包括（a）无菌填充有测量量的头孢呋辛的穿孔无菌小瓶，（b）具有无菌填充有0.1ml等渗剂的雄性鲁尔配方的重构注射器 在可穿孔小瓶中的每mg头孢呋辛盐溶液和具有阴性鲁尔接头或具有阴性鲁尔接头的一个或多个针的小瓶适配器，以及（c）一个或多个带有雄性鲁尔接头的灭菌递送注射器，每个输送注射器能够保持 至少0.1ml的可喷射液体，并含有一个标记，指示填充体积为0.1ml的可喷射液体。

公开(公告)号：US10251814B2

公开(公告)日：2019-04-09

申请号：US13261707

申请日：2012-02-14

Applicant: Rolf Schäfer

Inventor： Rolf Schäfer

IPC: A61J1/00 ,  A61J1/20 ,  A61K9/00 ,  A61M5/00 ,  A61M5/19 ,  A61M5/24 ,  A61M5/178 ,  A61M5/315 ,  A61K31/546 ,  F16D43/18

Abstract: The present invention relates to safety delivery systems for intracameral administration of an appropriate dose of cefuroxime subsequent to cataract and other eye surgery. A preferred embodiment of an cefuroxime safety delivery system according to the invention comprises (a) a perforable sterile vial sterile-filled with a measured amount of cefuroxime, (b) a reconstitution syringe with a male luer fitting sterile-filled with 0.1 ml of isotonic salt solution per mg cefuroxime in the perforable vial and a vial adapter with a female luer fitting or one or more needles with female luer fitting, and (c) one or more sterilized delivery syringes with male luer fitting, each delivery syringe being capable of holding at least 0.1 ml of ejectable liquid and containing a marking indicating a fill volume of 0.1 ml of ejectable liquid.

公开(公告)号：US08980957B2

公开(公告)日：2015-03-17

申请号：US13261345

申请日：2011-01-11

Applicant: Rolf Schäfer ,  Hans Hitz

Inventor： Rolf Schäfer ,  Hans Hitz

IPC: A61K47/32 ,  A61K47/30 ,  G02B1/04 ,  C08F8/30

CPC classification number: G02B1/043 ,  C08F8/30 ,  Y10S514/912 ,  C08F222/06

Abstract: The subject invention relates to a method of preparing a biocompatible polymer comprising epsilon-linked L-lysine having free alpha-amino and carboxy functions. The invention further encompasses the resulting biocompatible polymer and articles made from the polymer, in particular contact and intraocular lenses.

Abstract translation: 本发明涉及制备生物相容性聚合物的方法，其包含具有游离α-氨基和羧基官能团的ε连接的L-赖氨酸。 本发明还包括所得的生物相容性聚合物和由聚合物制成的制品，特别是接触和眼内透镜。

公开(公告)号：US20220409737A1

公开(公告)日：2022-12-29

申请号：US17771996

申请日：2020-10-30

Applicant: CIS PHARMA AG

Inventor： Christian GERATHS ,  Christophe THOMMEN ,  Michael HACKEBEIL ,  Davide PANIGHETTI ,  Hans HITZ

IPC: A61K47/68 ,  A61K47/58 ,  A61K51/10 ,  A61K51/06

Abstract: The present disclosure relates to the delivery of multiple copies of a payload molecule such as an active agent or a chelating agent capable of capturing an active agent, using as a carrier for their delivery a biocompatible copolymer comprising side chain-linked amino acids functionalized at their alpha-amino group by a reactive azide moiety by means of which the payload molecules are coupled to the copolymer. The copolymer is typically further functionalized to contain a single copy of a cell type- or tissue type-specific targeting moiety.

公开(公告)号：US11008414B2

公开(公告)日：2021-05-18

申请号：US15932509

申请日：2016-09-30

Applicant: CIS Pharma AG

Inventor： Christian Geraths ,  Rolf Schäfer

IPC: B29D11/00 ,  C07C231/02 ,  C07C319/12 ,  C07D207/16 ,  C08F220/20 ,  C08L83/04 ,  C08F293/00 ,  C08F222/38 ,  G02B1/04 ,  B29K105/00

Abstract: The present invention relates to copolymers made from a polymerization mixture comprising (a) one or more polymerizable monomers, which monomers are characterized as having at least one vinylic group and not containing an amino acid residue, (b) one or more not-functionalized side chain-linked amino acids, (c) one or more functionalized side chain-linked amino acids, (d) a free radical initiator and, optionally, (e) a chain-transfer-agent. It also relates to block copolymers comprising the same monomers. The invention also encompasses silicone hydrogel contact lenses coated with or comprising the latter copolymers and block copolymers as well methods for introducing the copolymers and block copolymers into silicone hydrogel contact lenses.

公开(公告)号：US20200283560A1

公开(公告)日：2020-09-10

申请号：US15932509

申请日：2016-09-30

Applicant: CIS Pharma AG

Inventor： Christian Geraths ,  Rolf Schäfer

IPC: C08F293/00 ,  C08F220/20 ,  C08F222/38 ,  C08L83/04 ,  C07C231/02 ,  C07D207/16 ,  C07C319/12 ,  B29D11/00 ,  G02B1/04

Abstract: The present invention relates to copolymers made from a polymerization mixture comprising (a) one or more polymerizable monomers, which monomers are characterized as having at least one vinylic group and not containing an amino acid residue, (b) one or more not-functionalized side chain-linked amino acids, (c) one or more functionalized side chain-linked amino acids, (d) a free radical initiator and, optionally, (e) a chain-transfer-agent. It also relates to block copolymers comprising the same monomers. The invention also encompasses silicone hydrogel contact lenses coated with or comprising the latter copolymers and block copolymers as well methods for introducing the copolymers and block copolymers into silicone hydrogel contact lenses.

公开(公告)号：US20230148604A1

公开(公告)日：2023-05-18

申请号：US17781961

申请日：2020-12-04

Applicant: CIS PHARMA AG

Inventor： Christian GERATHS ,  Rolf SCHAFER

IPC: A01N47/44 ,  A01N25/30 ,  A01N25/02 ,  A01N43/40 ,  A01N33/12 ,  A01N43/16 ,  A01P1/00 ,  A61L12/14

CPC classification number: A01N47/44 ,  A01N25/30 ,  A01N25/02 ,  A01N43/40 ,  A01N33/12 ,  A01N43/16 ,  A01P1/00 ,  A61L12/142 ,  A61L12/145

Abstract: The present invention relates to ophthalmic formulations wherein a synergistic combination of three different classes of disinfectants (a multimeric biguanide compound, a quaternary ammonium compound and an antifungal/anti-acanthamoeba compound, in particular a combination of polyhexamethylene biguanide, Polyquaternium-1 and myristamidopropyl dimethylamine) enables the use of high concentrations of hyaluronate for providing better comfort and support of corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of more than 7.5 times higher concentrations of hyaluronate than are present in currently marketed multi-purpose disinfection solutions.

公开(公告)号：US09839719B2

公开(公告)日：2017-12-12

申请号：US11920507

申请日：2006-05-22

Applicant: Hans Hitz ,  Rolf Schäfer ,  Christoph Schäfer

Inventor： Hans Hitz ,  Rolf Schäfer ,  Christoph Schäfer

IPC: A61L29/00 ,  A61L27/16

CPC classification number: C08F220/48 ,  A61K9/0048 ,  A61K47/32 ,  A61L15/24 ,  A61L17/00 ,  A61L27/16 ,  C08F220/06 ,  C08F220/28 ,  C08F2220/281 ,  G02B1/043 ,  C08L33/08 ,  C08L33/26

Abstract: The invention relates to highly biocompatible or biophilic un-cross-linked or cross-linked polymers comprising one or more side-chain active acrylic amino acids of formula I wherein: X is —NH(CH2)4—, —O—C6H4—CH2—, —OCH2—, —O—CH(CH3)—, —S—CH2—, —O-proline, and R is H or CH3; and wherein the polymer further includes a free radical initiator and, optionally, a cross-linking agent having a plurality of polymerizable ethylenically unsaturated groups. The invention further concerns various highly biocompatible, cross-linked co-polymers comprising one or more monomers of formula I, and one or more other polymerizable monomers. Uses of such polymers and co-polymers for the production of contact lenses, intraocular lenses, implants, wound healing slabs, additives for food and cosmetics, conductive plastics, spinnable fibers, and the like are disclosed.