-
公开(公告)号：US20240197719A1
公开(公告)日：2024-06-20
申请号：US18436976
申请日：2024-02-08
发明人： Roger CRYSTAL , Phil SKOLNICK , Edward T. MAGGIO
CPC分类号： A61K31/485 , A61K9/0043 , A61K47/186 , A61K47/26 , A61M11/007 , A61M11/008 , A61M15/08
摘要： Formulations and methods for the preventative treatment of incidental opioid overdose comprising the intranasal (IN) administration of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.
-
公开(公告)号：US20230085636A1
公开(公告)日：2023-03-23
申请号：US18049936
申请日：2022-10-26
IPC分类号： A61K47/26 , A61K31/7016 , A61K31/485
摘要： Drug products adapted for nasal delivery comprising formulations with epinephrine and devices comprising such formulations are provided. Methods of treating anaphylaxis with epinephrine products are also provided.
-
公开(公告)号：US20210220346A1
公开(公告)日：2021-07-22
申请号：US17055647
申请日：2019-05-15
发明人： Roger Crystal , Phil Skolnick , Edward T. Maggio
摘要： Formulations and methods for the preventative treatment of incidental opioid overdose comprising the intranasal (IN) administration of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.
-
公开(公告)号：US10046025B2
公开(公告)日：2018-08-14
申请号：US15264393
申请日：2016-09-13
发明人： Edward T. Maggio
摘要： The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a cyclic polypeptide.
-
公开(公告)号：US09446134B2
公开(公告)日：2016-09-20
申请号：US14494990
申请日：2014-09-24
发明人： Edward T. Maggio
IPC分类号： A61K38/08 , A61K47/26 , A61K9/00 , A61K9/127 , A61K9/19 , A61K31/70 , A61K45/06 , A61K47/10 , A61K47/18 , A61K47/36
CPC分类号： A61K38/12 , A61K9/0043 , A61K9/08 , A61K9/127 , A61K9/19 , A61K31/70 , A61K38/08 , A61K45/06 , A61K47/10 , A61K47/183 , A61K47/186 , A61K47/26 , A61K47/36
摘要： The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example octreotide or variant thereof.
摘要翻译： 本发明涉及含有烷基糖苷的组合物和增加其多肽，多肽或其变体（例如奥曲肽或其变体）的稳定性，降低聚集和免疫原性，增加生物学活性以及降低或预防纤维状形成的方法。
-
公开(公告)号：US08927497B2
公开(公告)日：2015-01-06
申请号：US13371274
申请日：2012-02-10
申请人： Edward T. Maggio
发明人： Edward T. Maggio
CPC分类号： A61K47/26 , A61K9/0043 , A61K9/0048 , A61K31/4439 , A61K31/70
摘要： A composition including a surfactant and at least one alkyl glycoside and/or saccharide alkyl ester and a drug. The surfactant composition(s) when admixed with a drug is non-toxic and non-irritating, while stabilizing and increasing the bioavailability of the drug. The invention also provides compositions that enhance absorption of drugs via the oral, ocular, nasal, nasolacrimal, inhalation or pulmonary, oral cavity (sublingual or Buccal cell) or CSF delivery route of a patient, including but not limited to insulin, glucagon and exendin-4.
摘要翻译： 包含表面活性剂和至少一种烷基糖苷和/或糖类烷基酯和药物的组合物。 当与药物混合时，表面活性剂组合物是无毒且无刺激性的，同时稳定并增加药物的生物利用度。 本发明还提供了通过口服，眼，鼻，鼻泪，吸入或肺，口腔（舌下或Buccal细胞）或CSF递送途径增加药物吸收的组合物，包括但不限于胰岛素，胰高血糖素和毒蜥外泌肽 -4。
-
公开(公告)号：US08772231B2
公开(公告)日：2014-07-08
申请号：US12896640
申请日：2010-10-01
申请人： Edward T. Maggio
发明人： Edward T. Maggio
IPC分类号： A61K38/28
CPC分类号： A61K31/70 , A61K9/0043 , A61K9/127 , A61K9/19 , A61K38/162 , A61K38/1816 , A61K38/21 , A61K38/27 , A61K38/28 , A61K38/29 , A61K47/26
摘要： The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of insulin or an analog thereof.
摘要翻译： 本发明涉及含有烷基糖苷的组合物和增加其稳定性，减少聚集和免疫原性，增加生物活性以及降低或预防胰岛素或其类似物的纤维形成的方法。
-
公开(公告)号：US08642564B2
公开(公告)日：2014-02-04
申请号：US12036963
申请日：2008-02-25
申请人： Edward T. Maggio
发明人： Edward T. Maggio
IPC分类号： A61K31/7028 , A61K31/7088 , C12N15/113
CPC分类号： A61K9/0043 , A61K9/0048 , A61K31/4439 , A61K31/70 , A61K47/26
摘要： A composition having at least one alkyl glycoside and at least one therapeutic agent, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms and wherein the therapeutic agent is an oligonucleotide.
摘要翻译： 一种具有至少一种烷基糖苷和至少一种治疗剂的组合物，其中所述烷基糖苷具有约10至约16个碳原子的烷基链长度，并且其中所述治疗剂是寡核苷酸。
-
公开(公告)号：US08551468B2
公开(公告)日：2013-10-08
申请号：US12189722
申请日：2008-08-11
申请人： Edward T. Maggio
发明人： Edward T. Maggio
IPC分类号： A61K38/21
CPC分类号： A61K47/26 , A61K9/0043 , A61K9/0048 , A61K31/4439 , A61K31/70
摘要： A composition including a surfactant and at least one alkyl glycoside and/or saccharide alkyl ester and a drug. The surfactant composition(s) when admixed with a drug is non-toxic and non-irritating, while stabilizing and increasing the bioavailability of the drug. The invention also provides compositions that enhance absorption of drugs via the oral, ocular, nasal, nasolacrimal, inhalation or pulmonary, oral cavity (sublingual or Buccal cell) or CSF delivery route of a patient, including but not limited to insulin, glucagon and exendin-4.
摘要翻译： 包含表面活性剂和至少一种烷基糖苷和/或糖类烷基酯和药物的组合物。 当与药物混合时，表面活性剂组合物是无毒且无刺激性的，同时稳定并增加药物的生物利用度。 本发明还提供了通过口服，眼，鼻，鼻泪，吸入或肺，口腔（舌下或Buccal细胞）或CSF递送途径增加药物吸收的组合物，包括但不限于胰岛素，胰高血糖素和毒蜥外泌肽 -4。
-
公开(公告)号：US08268791B2
公开(公告)日：2012-09-18
申请号：US12341696
申请日：2008-12-22
申请人： Edward T. Maggio
发明人： Edward T. Maggio
IPC分类号： A61K31/7016 , A61K31/404 , A61K31/4045
CPC分类号： A61K9/0043 , A61K9/0048 , A61K31/4439 , A61K31/70 , A61K47/26
摘要： The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at least one alkyl glycoside and at least one therapeutic agent, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.
摘要翻译： 本发明提供组合物和方法以及提高受试者中治疗剂的生物利用度。 组合物包括至少一种烷基糖苷和至少一种治疗剂，其中烷基糖苷具有约10至约16个碳原子的烷基链长度。
-
-
-
-
-
-
-
-
-
搜索结果
65 条记录 (耗时 0.051 秒)
