-
公开(公告)号：US20210154234A1
公开(公告)日：2021-05-27
申请号：US17146663
申请日：2021-01-12
IPC分类号： A61K35/19 , C12N5/078 , C12N5/00 , C12N5/0775 , C12N5/09
摘要： This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.
-
公开(公告)号：US11006620B2
公开(公告)日：2021-05-18
申请号：US16062417
申请日：2016-12-15
IPC分类号： A01K67/00 , A01K67/027 , C12N5/073 , A61K49/00 , C12N5/09
摘要： The invention concerns a gallinacean embryo in which cancer cells have been grafted within the embryo tissue, characterised in that the embryo is at a developmental stage between the HH10 and HH25 stages at the time of the grafting, wherein said cancer cells are not neuroblastoma cells and said cells form tumors inside the embryo.
-
公开(公告)号：US20210127663A1
公开(公告)日：2021-05-06
申请号：US16468390
申请日：2017-08-25
发明人： Heli PAUKKONEN , Vili-Veli AUVINEN , Marjo YLIPERTTULA , Patrick LAURÉN , Arto URTTI , Timo LAAKSONEN , Arto MERIVAARA , Tiina HAKKARAINEN , Outi MONNI , Anne MÄKELÄ , Petter SOMERSALO , Piia-Riitta KARHEMO , Heikki JOENSUU , Raili KOIVUNIEMI , Kari LUUKKO , Markus NUOPPONEN
摘要： The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.
-
公开(公告)号：US10988737B2
公开(公告)日：2021-04-27
申请号：US15568959
申请日：2016-04-28
申请人： UNIVERSITE DE STRASBOURG , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , INSTITUT HOSPITALIER UNIVERSITAIRE DE STRASBOURG , ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人： Thomas Baumert , Yujin Hoshida
摘要： The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. The cellular model system for hepatocellular carcinoma (HCC)/cirrhosis development and progression may be used in the screening of compounds useful in the treatment and/or prevention of cirrhosis and/or HCC as well as in the identification biomarkers for the prediction of liver disease (especially cirrhosis) progression and HCC. The present invention also relates to specific compounds that have been identified, using such screening methods, as useful in the treatment and/or the prevention of HCC/cirrhosis.
-
公开(公告)号：US10954545B2
公开(公告)日：2021-03-23
申请号：US15565175
申请日：2016-04-11
发明人： Mart Ustav , Ene Ustav , Andres Männik , Mart Toots , Mart Ustav, Jr. , Andres Tover
摘要： A U2OS-based model system using luciferase reporters to monitor the genome replication of alpha and beta HPVs is provided. A modified U2OS cell line is disclosed that expresses Firefly luciferase to measure toxicity of the screened compounds. In addition, provided are HPV18, HPV 16 and HPV5 marker genomes that express Renilla luciferase under the control of viral promoters used to measure changes in the viral copy number. This ready-to-use model system is capable of being used in high-throughput screens to identify compounds inhibiting initial amplification and stable maintenance as well as vegetative phase of various HPV subtypes.
-
公开(公告)号：US10952415B2
公开(公告)日：2021-03-23
申请号：US14003384
申请日：2012-03-09
申请人： Richard G. Pestell
发明人： Richard G. Pestell
IPC分类号： A61K31/46 , A01K67/027 , C12N5/09 , A61K31/506 , C12Q1/6886 , G01N33/574
摘要： The present disclosure, in part, is directed to a mammalian prostate cancer cell line comprising at least one or a set of primary mammalian epithelial cells which have been infected with a retroviral vector carrying an oncogene selected from the group consisting of c-Myc, Ha-Ras, NeuT, c-Src and combinations thereof and in which said gene is expressed. Applications of the pro-state cell lines, including immune competent animal models of prostate cancer, a method for the in vitro production of immortalized primary mammalian epithelial cells, a method of determining whether a human subject having prostate cancer is suffering from or at risk for developing metastasis, a method of preventing cancer or inhibiting metastasis of cancer susceptible to treatment in a subject at risk for developing cancer or metastasis of cancer, and method of identifying a candidate compound that selectively interferes with proliferation or viability of a cancer cell that has elevated levels of CCR5 and/or of at least one of its ligands.
-
公开(公告)号：US20210061921A1
公开(公告)日：2021-03-04
申请号：US17072434
申请日：2020-10-16
发明人： John T. NGO
摘要： Described herein are compositions, methods, and systems for modulating Notch receptor activation. Aspects of the invention relate to synthetic proteins comprising at least a Notch NRR (Negative Regulatory Region)-binding scFV fused to a transmembrane domain. Another aspect of the invention relates to drug-dependent synthetic proteins. Constructs and engineered cells comprising the synthetic proteins are additionally described herein.
-
公开(公告)号：US10933049B2
公开(公告)日：2021-03-02
申请号：US15579339
申请日：2016-06-01
发明人： Trent Woodruff , Barbara Rolfe
IPC分类号： A61K31/395 , A61K45/06 , C07K14/72 , C12N5/09 , A61P35/00 , A61K35/28 , A61K38/19 , A61K35/12
摘要： The present invention discloses the use of a complement 3a receptor (C3aR) antagonist and a mobilizer of hematopoietic stem cells and/or progenitor cells in methods and compositions for stimulating or enhancing the development, mobilization, proliferation and/or differentiation of a neutrophil-containing leukocyte population that inhibits growth and/or spread of a tumor and for treating or preventing a hyperproliferative cell disorder.
-
公开(公告)号：US10925901B2
公开(公告)日：2021-02-23
申请号：US16235392
申请日：2018-12-28
摘要： This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.
-
公开(公告)号：US20210046109A1
公开(公告)日：2021-02-18
申请号：US16980391
申请日：2019-03-14
发明人： Robert Blelloch , Mauro Poggio , Tianyi Hu
IPC分类号： A61K35/13 , A61K31/7105 , A61P35/00 , C12N5/09
摘要： Suppressive extracellular vesicles (EVs) such as PD-L1-bearing exosomes are produced by cancer cells and promote systemic suppression of the immune system, enabling tumors to escape immune surveillance. Inhibitors of suppressive EVs reduce the suppressive activity and/or the production of suppressive EVs, relieving systemic immunosuppression, and may be use to increase the efficacy of a co-administered immunotherapy. Additionally, engineered cancer cells that have an impaired capacity to produce PD-L1-bearing exosomes can be administered to prime the immune system against resident tumors, overcoming the systemic suppression of the immune system by cancer cells. Also, exogenously produced PD-L1-bearing exosomes may be administered to a subject for the treatment of an immune-related condition or to promote therapeutic immunosuppression.
-
-
-
-
-
-
-
-
-
搜索结果
1918 条记录 (耗时 0.04 秒)
