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646 条记录 (耗时 0.033 秒)

    Topical preparations for use in treatment of anorectal disease
    82.
    发明申请
    Topical preparations for use in treatment of anorectal disease 审中-公开
    用于治疗肛门直肠疾病的专题准备工作

    公开(公告)号：US20050074510A1

    公开(公告)日：2005-04-07

    申请号：US10678990

    申请日：2003-10-04

    申请人： Paul Bobrowski

    发明人： Paul Bobrowski

    IPC分类号： A61K36/00 ,  A61K36/47 ,  A61K45/06 ,  A61K35/78

    CPC分类号： A61K45/06 ,  A61K36/47 ,  A61K2300/00

    摘要： The invention herein describes an improved approach to managing hemorrhoids by combining current approaches of topical anesthetics, vasoconstrictors, ant-inflammatories, protectants, anti-pruretics, astringents, keratolytics, anticholinergics, cicatrizants, and antimicrobials with Croton species material. The botanical extracts are concentrated biologically active materials and thus provide enhanced therapeutic benefit. The Croton species components add a breadth and immediacy to the termination of neurogenic responses that mediate, sustain, and prolong the symptoms and underlying pathology.

    摘要翻译： 本发明描述了一种通过将局部麻醉剂，血管收缩剂，抗炎剂，保护剂，抗瘙痒剂，收敛剂，角质层分离剂，抗胆碱能药，瘢痕疙瘩和抗微生物剂与巴豆物质材料相结合的方法来管理痔疮的改进方法。 植物提取物是浓缩的生物活性物质，从而提供增强的治疗益处。 巴豆物种组分增加了广泛和直接性，终止了介导，维持和延长症状和潜在病理学的神经源性反应。

    Methods of stimulating the immune system
    85.
    发明授权
    Methods of stimulating the immune system 有权
    刺激免疫系统的方法

    公开(公告)号：US06844013B2

    公开(公告)日：2005-01-18

    申请号：US09888997

    申请日：2001-06-21

    申请人： James Harrison Aylward

    发明人： James Harrison Aylward

    IPC分类号： A61K31/00 ,  A61K31/045 ,  A61K31/12 ,  A61K31/22 ,  A61K31/445 ,  A61K36/47 ,  A61K35/78

    CPC分类号： A61K36/47

    摘要： This invention relates to a compound or group of compounds present in an active principle derived from plants of species Euphorbia peplus, Euphorbia hirta and Euphorbia drummondii, and to pharmaceutical compositions comprising these compounds. Extracts from these plants have been found to show selective cytotoxicity against several different cancer cell lines. The compounds are useful in effective treatment of cancers, particularly malignant melanomas and squamous cell carcinomas (SCCs). In a preferred embodiment of the invention, the compound is selected from the group consisting of jatrophanes, pepluanes, paralianes and ingenanes, and pharmaceutically-acceptable salts or esters thereof, and more particularly jatrophanes of Conformation II.

    摘要翻译： 本发明涉及存在于源自大戟属植物，大戟属和大戟属植物的活性成分中的化合物或一组化合物，以及包含这些化合物的药物组合物。 已经发现这些植物的提取物显示出对几种不同癌细胞系的选择性细胞毒性。 该化合物可有效治疗癌症，特别是恶性黑素瘤和鳞状细胞癌（SCC）。 在本发明的一个优选实施方案中，该化合物选自由琼脂糖，胡椒酰，对氨基苯甲酸和嵌合物组成的组，及其药学上可接受的盐或酯，更特别是构象II的麻疯树。

    Anti-cancer compounds
    86.
    发明申请
    Anti-cancer compounds 有权
    抗癌化合物

    公开(公告)号：US20050003031A1

    公开(公告)日：2005-01-06

    申请号：US10896811

    申请日：2004-07-22

    申请人： James Aylward

    发明人： James Aylward

    IPC分类号： C07D213/80 ,  A61K31/00 ,  A61K31/045 ,  A61K31/12 ,  A61K31/216 ,  A61K31/22 ,  A61K31/225 ,  A61K31/325 ,  A61K31/4406 ,  A61K31/445 ,  A61K31/455 ,  A61K36/00 ,  A61K36/47 ,  A61P17/02 ,  A61P35/00 ,  C07C69/533 ,  C07C69/78 ,  C07G99/00 ,  A61K35/78

    CPC分类号： A61K36/47 ,  A61K31/225 ,  A61K2300/00

    摘要： This invention relates to a compound or group of compounds present in an active principle derived from plants of species Euphorbia peplus, Euphorbia hirta and Euphorbia drummondii, and to pharmaceutical compositions comprising these compounds. Extracts from these plants have been found to show selective cytotoxicity against several different cancer cell lines. The compounds are useful in effective treatment of cancers, particularly malignant melanomas and squamous cell carcinomas (SCCs). In a preferred embodiment of the invention, the compound is selected from the group consisting of jatrophanes, pepluanes, paralianes and ingenanes, and pharmaceutically-acceptable salts or esters thereof, and more particularly jatrophanes of Conformation II.

    摘要翻译： 本发明涉及存在于源自大戟属植物，大戟属和大戟属植物的活性成分中的化合物或一组化合物，以及包含这些化合物的药物组合物。 已经发现这些植物的提取物显示出对几种不同癌细胞系的选择性细胞毒性。 该化合物可有效治疗癌症，特别是恶性黑素瘤和鳞状细胞癌（SCC）。 在本发明的一个优选实施方案中，该化合物选自由琼脂糖，胡椒酰，对氨基苯甲酸和嵌合物组成的组，及其药学上可接受的盐或酯，更特别是构象II的麻风病毒。

    Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care
    88.
    发明申请
    Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care 审中-公开

    公开(公告)号：US20040220119A1

    公开(公告)日：2004-11-04

    申请号：US10817330

    申请日：2004-04-02

    申请人： Unigen Pharmaceuticals, Inc.

    发明人： Qi Jia

    IPC分类号： A61K031/7048 ,  A61K031/353

    CPC分类号： A61K8/97 ,  A61K8/498 ,  A61K8/67 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7048 ,  A61K36/11 ,  A61K36/15 ,  A61K36/185 ,  A61K36/28 ,  A61K36/47 ,  A61K36/48 ,  A61K36/484 ,  A61K36/486 ,  A61K36/53 ,  A61K36/539 ,  A61K36/54 ,  A61K36/60 ,  A61K36/906 ,  A61K36/9062 ,  A61K45/06 ,  A61K2800/782 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/08 ,  A61K2300/00

    摘要： The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compoundsnullFree-B-Ring flavonoids and flavansnullfor use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX). The method for preventing and treating COX and LOX mediated diseases and conditions of the skin is comprised of topically administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of COX and LOX mediated diseases and conditions, including but not limited to sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial and viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma, as well as other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind and dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin. Use of the composition described herein also affords the benefit of smooth and youthful skin with improved elasticity, reduced and delayed aging, enhanced youthful appearance and texture, and increased flexibility, firmness, smoothness and suppleness.

    Enriched aqueous components of emblica officinalis
    89.
    发明申请
    Enriched aqueous components of emblica officinalis 审中-公开
    水果成分丰富

    公开(公告)号：US20040126446A1

    公开(公告)日：2004-07-01

    申请号：US10660742

    申请日：2003-09-12

    申请人： EM Industries

    发明人： Ratan K. Chaudhuri ,  Germain Puccetti

    IPC分类号： A61K035/78

    CPC分类号： A61K36/47 ,  A61K8/97 ,  A61Q17/04 ,  A61Q19/08

    摘要： In an extraction process comprising extracting a raw extract from Emblica officinalis the improvement comprising conducting the extraction under conditions of time, temperature and atmosphere, to inhibit the formation of black specks and/or oligomeric and/or polymeric tannins and/or oxidation products thereof.

    摘要翻译： 在提取方法中，包括从果皮提取原始提取物，其改进包括在时间，温度和气氛条件下进行提取，以抑制黑斑和/或低聚和/或聚合物单宁和/或其氧化产物的形成。