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公开(公告)号：US20210325652A1
公开(公告)日：2021-10-21
申请号：US17236941
申请日：2021-04-21
发明人： Jialei Tang , Vahid Ebrahimi , Kyu Young Han
IPC分类号： G02B21/06 , G02B3/06 , G02B27/09 , G02B27/48 , G02B21/02 , G02B21/36 , G02B21/16 , G02B21/26 , G01N21/64
摘要： An illumination system may include an illumination source, a line-projection system to simultaneously illuminate a pupil plane with a static distribution of a plurality of one-dimensional (1D) coherent beams. Each of the 1D coherent beams of the plurality of 1D coherent beams may extend lengthwise along a coherent direction between boundaries of the pupil plane, have a width along an incoherent direction perpendicular to the coherent direction, and are distributed in a parallel distribution along the incoherent direction. Each of the 1D coherent beams of the plurality of 1D coherent beams is also spatially coherent along the coherent direction and spatially incoherent along the incoherent direction. The system may further include an objective lens to form a light sheet in an imaging plane based on an incoherent superposition of the plurality of 1D coherent beams.
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82.发明授权公开(公告)号：US11087508B2
公开(公告)日：2021-08-10
申请号：US16206922
申请日：2018-11-30
申请人： CANON MEDICAL SYSTEMS CORPORATION , THE UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, Inc.
发明人： Alexander Katsevich , Zhou Yu , Daxin Shi
IPC分类号： G06T11/00
摘要： A method and apparatus is provided to reconstruct a computed tomography image using iterative reconstruction (IR) that is accelerated using various combinations of ordered subsets, conjugate gradient, preconditioning, resetting/restarting, and/or gradient approximation techniques. For example, when restarting criteria are satisfied the IR algorithm can be reset by setting conjugate-gradient parameters to initial values and/or by changing the number of ordered subsets. The IR algorithm can be accelerated by approximately calculating the gradients, by using a diagonal or Fourier preconditioner, and by selectively updating the preconditioner based on the regularization function. The update direction and step size can be calculated using the preconditioner and a surrogate function, which is not necessarily separable.
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公开(公告)号：US20210236665A1
公开(公告)日：2021-08-05
申请号：US17234323
申请日：2021-04-19
IPC分类号： A61K51/06 , A61P35/00 , A61K31/519 , A61K49/04 , C08G63/688 , C08G83/00
摘要： Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanoparticles can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapeutic compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.
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公开(公告)号：US20210217307A1
公开(公告)日：2021-07-15
申请号：US17248142
申请日：2021-01-11
发明人： Mohamed Abdel-Aty , Ou Zheng , Yina Wu , Jinghui Yuan
摘要： A real-time traffic safety visualization and management system using traffic data, social media data, weather data, and other similar data enable proactive decisions for reducing the number of traffic incidents or mitigating their severity. The system utilizes predictive algorithms in a hybrid framework to diagnose real-time traffic safety conditions. Meanwhile, Pro-active Traffic Management (PATM) Strategies are provided by the system for the predicted high-risk locations. Moreover, through the visualization and management system, various countermeasures are considered and tested for decision makers, such that one or more of the most effective countermeasures are recommended within a given area to improve traffic safety thereof.
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公开(公告)号：US20210187128A1
公开(公告)日：2021-06-24
申请号：US17131956
申请日：2020-12-23
申请人： University of Central Florida Research Foundation, Inc. , The Regents of the University of Colorado, a Body Corporate
发明人： Sudipta Seal , Sushant Singh , Kenneth W. Liechty , Carlos Zgheib
摘要： An electrospun nanofibrous silk fibroin mat infused with a reactive oxygen species (ROS) detection reagent is presented herein. The ROS detection agent may be Amplex red. A method of real time detection of ROS in a wound site to determine the need for a dressing change is also presented. The method includes applying an electrospun nanofibrous silk fibroin mat infused with Amplex red to a wound site of a patient and detecting a change in color of the mat. A color change indicates a higher than normal level of ROS in the wound site. Depending on the degree of color change, a therapeutic agent may be administered to the wound site and a new mat applied to measure ROS in the wound site after therapy is administered.
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公开(公告)号：US11042671B1
公开(公告)日：2021-06-22
申请号：US16946958
申请日：2020-07-13
IPC分类号： G06F30/12 , B33Y50/02 , G06F113/10
摘要： Methods of optimizing additive manufacturing processes for improved efficiencies and accuracies, particularly by simplifying the user interface portions of the processes. The methods use path-finding calculations, such as vector fields, vector trails, and texture maps, to form accurate models from which replica composite objects can be printed, without requiring complex parameter inputs and calculations from the user. The methods measure and plot vector fields by considering the location of a particle within the volume of an object at various points of time to develop a strand-like model that is used to manufacture a replica object.
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87.发明申请公开(公告)号：US20210174492A1
公开(公告)日：2021-06-10
申请号：US17247389
申请日：2020-12-09
发明人： Enes Karaaslan , Fikret Necati Catbas , Ulas Bagci
摘要： A smart, human-centered technique that uses artificial intelligence and mixed reality to accelerate essential tasks of the inspectors such as defect measurement, condition assessment and data processing. For example, a bridge inspector can analyze some remote cracks located on a concrete pier, estimate their dimensional properties and perform condition assessment in real-time. The inspector can intervene in any step of the analysis/assessment and correct the operations of the artificial intelligence. Thereby, the inspector and the artificial intelligence will collaborate/communicate for improved visual inspection. This collective intelligence framework can be integrated in a mixed reality supported see-through headset or a hand-held device with the availability of sufficient hardware and sensors. Consequently, the methods reduce the inspection time and associated labor costs while ensuring reliable and objective infrastructure evaluation. Such methods offer contributions to infrastructure inspection, maintenance, management practice, and safety for the inspection personnel.
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88.发明授权公开(公告)号：US11022605B2
公开(公告)日：2021-06-01
申请号：US16328417
申请日：2017-08-16
摘要： Disclosed herein are cell culture analog devices, systems and methods for applying stimuli to components containing different cell types and recording the cell responses before, during, and after a stimulus (for example, a drug, metabolite, toxin, or electrical stimulus) is introduced. Responses can be stored to a database and compared to previous results. By analyzing how each cell type responds to various stimulation parameters, for example, by using multivariate analyses, cell signaling pathway information can be determined or new pathways can be discovered. In some implementations, an individual component interfaces with a specific cell type. This facilitates readout of the cell response to the stimulation. Various components can also interface with each other, such that the behavior of one cell type can affect a cell type in another component. Once assembled, the system is plugged into readout electronics and a programmable electrical stimulator.
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公开(公告)号：US11010902B2
公开(公告)日：2021-05-18
申请号：US16431387
申请日：2019-06-04
发明人： Ulas Bagci , Rodney LaLonde
摘要： An improved method of performing object segmentation and classification that reduces the memory required to perform these tasks, while increasing predictive accuracy. The improved method utilizes a capsule network with dynamic routing. Capsule networks allow for the preservation of information about the input by replacing max-pooling layers with convolutional strides and dynamic routing, allowing for the reconstruction of an input image from output capsule vectors. The present invention expands the use of capsule networks to the task of object segmentation and medical image-based cancer diagnosis for the first time in the literature; extends the idea of convolutional capsules with locally-connected routing and propose the concept of deconvolutional capsules; extends the masked reconstruction to reconstruct the positive input class; and proposes a capsule-based pooling operation for diagnosis. The convolutional-deconvolutional capsule network shows strong results for the tasks of object segmentation and classification with substantial decrease in parameter space.
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公开(公告)号：US10947131B2
公开(公告)日：2021-03-16
申请号：US16829844
申请日：2020-03-25
发明人： Ni-Bin Chang , Martin P. Wanielista
IPC分类号： C02F1/28 , B01J20/10 , B01J20/02 , B01J20/12 , B01D24/02 , B01J20/28 , B01J20/04 , C02F103/00 , C02F101/10 , C02F101/16
摘要： A method of water treatment includes flowing water that includes nitrogen and phosphorus compounds through a sorption media composition within at least one chamber of a water treatment system. The composition comprises iron filings comprising at least 5 volume (vol) % of the composition, sand particles comprising at leak 10 vol % of the composition, and clay particles comprising at least 2 vol % of the composition. The iron filings, sand particles, and clay particles are mixed together. During the flowing, the clay particles attract the nitrogen and phosphorus compounds, which become absorbed onto a surface of the iron filings and the clay, resulting in a removal of the nitrogen and phosphorus compounds and the generation of reaction products. Nitrogen and phosphorus are then recovered from the reaction products.
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