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![5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives](/abs-image/US/2015/07/14/US09079910B2/abs.jpg.150x150.jpg)
81.发明授权5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives 有权5-（1,2,3-三唑-4-基）-7H-吡咯并[2,3-D]嘧啶衍生物公开(公告)号：US09079910B2
公开(公告)日：2015-07-14
申请号：US13978545
申请日：2011-12-15
IPC分类号： C07D487/04 , C07D487/02 , A61K31/519 , A61K45/06
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D487/02
摘要： Compounds of the formula (I), in which R1, R2, R2a and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.
摘要翻译： 其中R1，R2，R2a和R3具有权利要求1所述含义的式（I）化合物是PDK1的抑制剂和细胞增殖/细胞活力，可用于治疗肿瘤。
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![Substituted 7-(1,2,3-Triazol-4-yl)-pyrrolo[2,3-b]pyrazines](/abs-image/US/2014/10/21/US08865715B2/abs.jpg.150x150.jpg)
82.发明授权公开(公告)号：US08865715B2
公开(公告)日：2014-10-21
申请号：US13882872
申请日：2011-10-12
IPC分类号： A61K31/4985 , C07D487/04 , A61K45/06
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06
摘要： The invention relates to compounds the formula (I): and pharmaceutically usable salts, tautomers and stereoisomers thereof, wherein R1, R2 and R3 are defined herein. The compounds of formula (I) and their pharmaceutically usable salts, tautomers and stereoisomers are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.
摘要翻译： 本发明涉及式（I）化合物及其药学上可用的盐，互变异构体和立体异构体，其中R 1，R 2和R 3在本文中定义。 式（I）化合物及其药学上可用的盐，互变异构体和立体异构体是PDK1的抑制剂和细胞增殖/细胞活力，可用于治疗肿瘤。
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![2,4-diaryl-substituted [1,8] naphthyridines as kinase inhibitors for use against cancer](/abs-image/US/2014/07/29/US08791113B2/abs.jpg.150x150.jpg)
83.发明授权2,4-diaryl-substituted [1,8] naphthyridines as kinase inhibitors for use against cancer 有权2,4-二芳基取代的[1,8]萘啶作为抗癌剂的激酶抑制剂公开(公告)号：US08791113B2
公开(公告)日：2014-07-29
申请号：US13807119
申请日：2011-05-31
IPC分类号： A61K31/535 , C07D413/00
CPC分类号： C07D491/048 , A61K31/4375 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/04 , C07D519/00
摘要： The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新颖的[1,8]萘啶衍生物，以及这样的化合物的用途，其中ATP消耗蛋白质如激酶的信号转导的抑制，调节和/或调节起着重要的作用，特别是 TGF-β受体激酶的抑制剂，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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![PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES](/abs-image/US/2013/12/26/US20130345227A1/abs.jpg.150x150.jpg)
84.发明申请公开(公告)号：US20130345227A1
公开(公告)日：2013-12-26
申请号：US14002991
申请日：2012-02-13
IPC分类号： C07D471/04 , A61K31/4985 , C07D491/048 , A61K45/06
CPC分类号： C07D471/04 , A61K31/4985 , A61K45/06 , C07D491/048
摘要： The present invention relates to novel pyrido[2,3-b]pyrazine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新颖的吡啶并[2,3-b]吡嗪衍生物，以及其中抑制，调节和/或调节ATP消耗蛋白质如激酶的信号转导的化合物的用途 ，特别是TGF-β受体激酶的抑制剂，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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![Hetaryl-[1,8]naphthyridine derivatives](/abs-image/US/2013/12/24/US08614226B2/abs.jpg.150x150.jpg)
公开(公告)号：US08614226B2
公开(公告)日：2013-12-24
申请号：US13574282
申请日：2010-12-17
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02
CPC分类号： C07D471/04 , A61K31/4375 , C07D401/14 , C07D413/14 , C07D519/00
摘要： Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) wherein R1, R2, W1, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.
摘要翻译： 其中R 1，R 2，W 1，W 3，W 5和W 6具有权利要求1的含义的式（I）的新型杂芳基 - [1,8]二氮杂萘衍生物是ATP消耗蛋白质的抑制剂， 用于治疗肿瘤。
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公开(公告)号：US08557977B2
公开(公告)日：2013-10-15
申请号：US13527008
申请日：2012-06-19
IPC分类号： C07D345/00
CPC分类号： C07D471/04
摘要： Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are inhibitors of cell proliferation\cell vitality and can be employed for the treatment of tumors.
摘要翻译： 其中R1，R2，R3，R4和R5具有权利要求1所述含义的式（I）化合物是细胞增殖抑制剂\细胞活力，可用于治疗肿瘤。
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公开(公告)号：US08445489B2
公开(公告)日：2013-05-21
申请号：US12602284
申请日：2008-05-02
申请人： Frank Stieber , Oliver Schadt , Dieter Dorsch , Andree Blaukat
发明人： Frank Stieber , Oliver Schadt , Dieter Dorsch , Andree Blaukat
IPC分类号： A61K31/535 , C07D413/12
CPC分类号： C07D237/14 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12
摘要： Compounds of the formula I, in which R1, R2, R3, R4, R5 and X have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.
摘要翻译： R 1，R 2，R 3，R 4，R 5和X具有权利要求1中所示含义的式I化合物是酪氨酸激酶，特别是Met激酶的抑制剂，可用于治疗 肿瘤。
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公开(公告)号：US20130102608A1
公开(公告)日：2013-04-25
申请号：US13808369
申请日：2011-06-07
IPC分类号： C07D401/14 , A61K45/06 , A61K31/496 , A61K31/4545 , A61K31/5377 , A61K31/444
CPC分类号： C07D401/14 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D471/04
摘要： The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新型联吡啶衍生物和其中ATP消耗蛋白质如激酶的信号转导的抑制，调节和/或调节起到特别是TGF-β抑制剂的作用的用途 受体激酶，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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![3 (3-pyrimidin-2-ylbenzyl)-1,2,4-triazolo[4,3-b]pyridazine derivatives](/abs-image/US/2013/04/23/US08426397B2/abs.jpg.150x150.jpg)
89.发明授权3 (3-pyrimidin-2-ylbenzyl)-1,2,4-triazolo[4,3-b]pyridazine derivatives 有权3（3-嘧啶-2-基苄基）-1,2,4-三唑并[4,3-b]哒嗪衍生物公开(公告)号：US08426397B2
公开(公告)日：2013-04-23
申请号：US13141447
申请日：2009-11-26
申请人： Dieter Dorsch , Oliver Schadt , Frank Stieber , Andree Blaukat
发明人： Dieter Dorsch , Oliver Schadt , Frank Stieber , Andree Blaukat
IPC分类号： A61K31/33
CPC分类号： C07D487/04 , A61K9/0019 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/2018
摘要： Compounds of the formula (I), in which R1, R2, R3, R3′, R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.
摘要翻译： 式（I）的化合物，其中R 1，R 2，R 3，R 3'，R 4具有权利要求1所示的含义，是酪氨酸激酶，特别是Met激酶的抑制剂，并且可以特别用于治疗 的肿瘤。
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公开(公告)号：US20110269756A1
公开(公告)日：2011-11-03
申请号：US13143467
申请日：2009-12-08
申请人： Frank Stieber , Oliver Schadt , Dieter Dorsch , Andree Blaukat
发明人： Frank Stieber , Oliver Schadt , Dieter Dorsch , Andree Blaukat
IPC分类号： A61K31/5377 , A61K31/4245 , A61P35/04 , A61K31/506 , C07D417/10 , C07D413/12 , A61K31/496 , C07D417/14
CPC分类号： C07D417/10 , C07D277/68 , C07D417/14
摘要： Compounds of the formula I, in which R1, R2, R3, R3′, R4, R4′, E, E′, E″ and E′″ have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours.
摘要翻译： 其中R1，R2，R3，R3'，R4，R4'，E，E'，E“和E”“具有权利要求1所示含义的式I化合物是酪氨酸激酶抑制剂，特别是Met 激酶，并且可以特别用于治疗肿瘤。
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