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公开(公告)号：US5114921A
公开(公告)日：1992-05-19
申请号：US613923
申请日：1990-11-06
申请人： Michael Zasloff
发明人： Michael Zasloff
CPC分类号： C07K7/06 , C07K14/46 , C07K5/1008 , C07K7/08 , A61K38/00
摘要： Amphiphilic biologically active peptides and intermediates. For example, the polypeptide comprises a chain of at least four groups of four amino acids. In each group of four amino acids, two amino acids are hydrophobic, one amino acid is basic hydrophilic, and the remaining amino acid is basic or neutral hydrophilic. A preferred amino acid sequence is Ala-Phe-Ser-Lys.
摘要翻译： 两亲生物活性肽和中间体。 例如，多肽包含至少四个四个氨基酸的链。 在每组四个氨基酸中，两个氨基酸是疏水性的，一个氨基酸是碱性亲水性的，剩余的氨基酸是碱性或中性亲水性的。 优选的氨基酸序列是Ala-Phe-Ser-Lys。
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82.发明公开公开(公告)号：US20240325308A1
公开(公告)日：2024-10-03
申请号：US18293419
申请日：2022-08-03
IPC分类号： A61K9/127 , A61K31/7105 , G01N33/50
CPC分类号： A61K9/1271 , A61K31/7105 , G01N33/5026 , G01N33/5076
摘要： The present disclosure relates, in part, to lipid nanoparticles (LNPs), and compositions comprising the same, which have increased stability in amniotic fluid, and methods of use thereof for in utero delivery of therapeutic agents, to treat and/or prevent diseases and/or disorders in a fetal subject. The present disclosure further relates to an ex vivo assay for screening LNP stability in a test fluid.
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公开(公告)号：US20240100036A1
公开(公告)日：2024-03-28
申请号：US18497338
申请日：2023-10-30
发明人： Hakon Hakonarson , Charlly Kao
IPC分类号： A61K31/454 , A61K45/06 , C12Q1/6883
CPC分类号： A61K31/454 , A61K45/06 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
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公开(公告)号：US20240041981A1
公开(公告)日：2024-02-08
申请号：US18060725
申请日：2022-12-01
发明人： Gregory Babcock , Wayne Hancock
IPC分类号： A61K38/20 , A61K31/436 , A61P37/06
CPC分类号： A61K38/2013 , A61K31/436 , A61P37/06
摘要： Methods of using IL-2 fusion proteins to treat and/or prevent transplant rejection such as heart transplant rejection are disclosed.
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公开(公告)号：US11833256B2
公开(公告)日：2023-12-05
申请号：US16622366
申请日：2018-06-20
发明人： Masahiro Iwamoto , Michael Chorny
IPC分类号： A61K9/51 , A61K9/19 , A61K31/192 , A61K31/415 , A61P19/08
CPC分类号： A61K9/5192 , A61K9/19 , A61K9/5153 , A61K31/192 , A61K31/415 , A61P19/08
摘要： The invention relates to compositions and methods as part of a pharmacotherapeutic strategy that targets the endochondral ossification process in a pharmacologically selective and site-specific manner. A variety of orthopedic pathologies are caused by or associated with generalized or local dysregulation of endochondral ossification, for example trauma to the bone growth plate or diaphysis can cause a serious imbalance in bone growth, leading to progressive deformity that today can only be treated surgically. Dysregulated endochondral ossification is also behind heterotopic ossification, which arises in soft tissues and causes pain, decrease in mobility and other clinical problems. The invention therefore provides RARy agonist and antagonist nanoparticle compositions for treating abnormal endochondral ossification and bone growth that can deliver robust local therapeutic control over a particular long bone's growth with a long-lasting effect.
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公开(公告)号：US20230310246A1
公开(公告)日：2023-10-05
申请号：US18330548
申请日：2023-06-07
发明人： Alan Flake , Emily Partridge , Marcus Davey
CPC分类号： A61G11/00 , A61M1/1698 , A61M1/168 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/7518 , A61M2240/00
摘要： Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.
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公开(公告)号：US20230304018A1
公开(公告)日：2023-09-28
申请号：US18047189
申请日：2022-10-17
发明人： Hakon Hakonarson , Rahul Pandey , Marina Bakay , Heather Hain
IPC分类号： C12N15/113 , A61P3/04 , A61K45/06
CPC分类号： C12N15/1138 , A61P3/04 , A61K45/06
摘要： Compositions and methods for the detection and treatment of obesity and other neurological disorders are provided.
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公开(公告)号：US11707394B2
公开(公告)日：2023-07-25
申请号：US17093847
申请日：2020-11-10
发明人： Alan Flake , Emily Partridge , Marcus Graeme Davey
CPC分类号： A61G11/00 , A61M1/1698 , A61M1/168 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/7518 , A61M2240/00
摘要： Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.
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公开(公告)号：US11690651B2
公开(公告)日：2023-07-04
申请号：US17164932
申请日：2021-02-02
CPC分类号： A61B17/50 , A61B17/221 , A61B17/22031 , A61F2/962 , A61B2017/00367 , A61B2017/00778 , A61B2017/2215 , A61B2017/22034 , A61B2017/22035 , A61F2/2427 , A61F2002/9528 , A61F2002/9623
摘要： Disclosed are systems, methods, and devices for percutaneous retrieval of objects, such as endovascular devices, from an internal body space. The present inventions have vascular, non-vascular (gastrointestinal), and surgical (laproscopic) applications. The inventions include a retrieval end having one or more compressed states and an expanded state, the retrieval end adopting the expanded state when the retrieval end is deployed into a subject's internal body space, the retrieval end having a mouth through which an object can be passed into an interior space within the retrieval end when the retrieval end is in the expanded state, the mouth being adjustable between an opened state and a closed state; wherein when at least a portion of the retrieval end of the inner sheath is transitioned to a compressed state following capture of the object, the retrieval end exerts an inward force that at least partially collapses or compresses the object.
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公开(公告)号：US20230088814A1
公开(公告)日：2023-03-23
申请号：US18060098
申请日：2022-11-30
发明人： Tom Leyssens , Bram Harmsen
IPC分类号： C07D401/06
摘要： The disclosure is directed to crystalline forms and mixtures thereof of R-fasoracetam. Such crystalline forms include Form II monohydrate R-fasoracetam and the anhydrate form of R-fasoracetam. The disclosure further includes mixtures of the anhydrate form of R-fasoracetam together with one or more of Form I monohydrate R-fasoracetam and Form II monohydrate R-fasoracetam.
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