公开(公告)号：US20120046736A1

公开(公告)日：2012-02-23

申请号：US13128078

申请日：2009-11-04

Applicant: Shih-Horng Su ,  Fuh-Sheng Chen ,  Debashis Dutta

Inventor： Shih-Horng Su ,  Fuh-Sheng Chen ,  Debashis Dutta

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61F2/0077 ,  A61F2/04 ,  A61F2/06 ,  A61F2/848 ,  A61F2002/0081 ,  A61F2230/0002 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2250/0071 ,  A61K33/00 ,  A61L2400/12

Abstract: Devices and methods for controlling the flaking of coating fragments from medical implants and improving the delivery of therapeutic agents from such coatings are described.

公开(公告)号：US20110123704A1

公开(公告)日：2011-05-26

申请号：US13023312

申请日：2011-02-08

Applicant: Douglas R. Savage ,  Ronald E. Betts

Inventor： Douglas R. Savage ,  Ronald E. Betts

IPC: B05D5/00 ,  A61L33/00

CPC classification number: A61L31/16 ,  A61F2/91 ,  A61L2300/416

Abstract: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments and a liquid-infusible mechanical anchoring layer attached to or formed in outer surface of the filaments. A drug coating in the stent is composed of a substantially polymer-free composition of an anti-restenosis drug, and has a substratum infused in the anchoring layer and a substantially continuous surface stratum of drug that is brought into direct contact with the vessel walls at the vascular site. Thus, the rate of release of the anti-restenosis drug from the surface stratum into said vascular site is determined solely by the composition of said drug coating.

Abstract translation: 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 该支架包括由一个或多个金属细丝形成的径向可扩张体，以及附着于细丝的外表面或形成于细丝的外表面的液体不可渗透的机械锚定层。 支架中的药物涂层由基本上无聚合物的抗再狭窄药物组合物组成，并且具有注入锚固层中的基质和药物的基本连续的表面层，其与血管壁直接接触 血管部位。 因此，抗再狭窄药物从表层到所述血管部位的释放速率仅由所述药物包衣的组成确定。