公开(公告)号：US20190388803A1

公开(公告)日：2019-12-26

申请号：US16563793

申请日：2019-09-06

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Per KARLBERG ,  Erik RURLING ,  Joakim LUNDKVIST

IPC: B01D15/20

Abstract: A method for packing a media bed in a column (3). According to the invention the method comprises the steps of: providing data to a control unit (15) connected to the column (3), said data comprising at least a measured slurry concentration, a target bed height, a target packing factor or compression factor and minimum and maximum acceptable values for at least one of target bed height and target packing or compression factor; forcing a movable adapter (9) along a longitudinal axis of the column (3) in order to pack the media; detecting when the media bed is consolidated; the control unit (15) processing the provided data and the information about the consolidated bed height in order to present to the user acceptable bed heights, if there are any, giving acceptable packing or compression factors.

公开(公告)号：US20190385756A1

公开(公告)日：2019-12-19

申请号：US16555140

申请日：2019-08-29

Applicant: Kurion, Inc.

Inventor： Joshua MERTZ ,  Ja-Kael LUEY ,  Wes BRATTON ,  Kenneth SCHOFIELD

IPC: G21F9/12 ,  B01D15/20 ,  B01D15/36 ,  B01J45/00 ,  B01J47/10

Abstract: Disclosed herein are systems, methods, processes, and apparatuses for treating radioactive waste, through systems designed to bind and dry radioactive media. In some of its various embodiments, the system includes at least one helical screw designed to receive and mix liquid wastes with ion exchange media, as well as convey the resulting slurry through one or more of a binding, dewatering, and drying/off-gassing region.

公开(公告)号：US20190322736A1

公开(公告)日：2019-10-24

申请号：US16389114

申请日：2019-04-19

Applicant: Janssen Biotech, Inc.

Inventor： Paul Randolph

IPC: C07K16/24 ,  C07K1/22 ,  C07K1/18 ,  B01D15/20 ,  B01D15/38 ,  B01D15/36

Abstract: A method of operating a chromatography column is described for use in methods of manufacture for producing anti-IL-12/IL-23p40 antibodies, e.g., the anti-IL-12/IL-23p40 antibody STELARA® (ustekinumab). This method involves collecting column outlet signal and accumulated flow parameters at two or more intervals of at least one mobile phase transition front during operation of the chromatography column comprising column packing. A model gamma cumulative distribution curve is calculated based on the collected column outlet signal and accumulated flow parameters for the at least one mobile phase transition front. A height equivalent theoretical plate (HETP) value is calculated for the at least one mobile phase transition front using parameters of the model gamma cumulative distribution curve and the quality of the chromatography column packing is assessed based on the calculated HETP value.

公开(公告)号：US20190321752A1

公开(公告)日：2019-10-24

申请号：US16389146

申请日：2019-04-19

Applicant: Janssen Biotech, Inc.

Inventor： Paul Randolph

IPC: B01D15/16 ,  B01D15/20 ,  G01N35/00

Abstract: A method of operating a chromatography column is described. This method involves collecting column outlet signal and accumulated flow parameters at two or more intervals of at least one mobile phase transition front during operation of the chromatography column comprising column packing. A model gamma cumulative distribution curve is calculated based on the collected column outlet signal and accumulated flow parameters for the at least one mobile phase transition front. A height equivalent theoretical plate (HETP) value is calculated for the at least one mobile phase transition front using parameters of the model gamma cumulative distribution curve and the quality of the chromatography column packing is assessed based on the calculated HETP value.

公开(公告)号：US20190310233A1

公开(公告)日：2019-10-10

申请号：US16378899

申请日：2019-04-09

Applicant: Dr. Albin Maisch High Performance LC GmbH

Inventor： Albin Maisch

IPC: G01N30/22 ,  B01D15/20 ,  B01D15/22 ,  G01N30/56 ,  G01N30/60

Abstract: A separating column for use with a filling tube to prepare for chromatography is disclosed. The separating column includes an axially movable spring stamp; and a plurality of springs coupled to the stamp. Moreover, the stamp is depressed directly into the column tube during column packing via the filling tube. Additionally, the stamp is fixed in the column tube while maintaining the packing pressure so that the springs are compressed during the packing process and press the stamp permanently and dynamically onto a chromatographic bed.

公开(公告)号：US20190308169A1

公开(公告)日：2019-10-10

申请号：US16315088

申请日：2017-07-14

Applicant: Puridify Ltd.

Inventor： Marc Hummersone ,  Benjamin Wallis ,  Frederic Leroux ,  William Law

IPC: B01J20/26 ,  B01J20/28 ,  B01J20/289 ,  B01J20/30 ,  B01J20/32 ,  C07K1/16 ,  B01D15/20 ,  B01D15/38

Abstract: The present invention provides a functionalised polymeric chromatography medium, prepared by a process which comprises (i) providing a substrate formed of one or more polymer nanofibres, (ii) grafting one or more neutral polymer chains from the substrate, and (iii) contacting the grafted product with a reagent which functionalises the product of step (ii) as a chromatography medium, wherein step (ii) comprises reacting a plurality of compounds of formula and/or its enantiomers, and/or its derivatives of formula (I) and/or enantiomers and/or diastereomers thereof: with one or more functional groups present on the nanofibre substrate, wherein R1, R2, R3, R4 and R5 may be the same or different, and are chosen from H, halogen, C1-C4 alkyl, or C1-C4 alkoxy provided that at least one of R1, R2, R3, R4 or R5 is not hydrogen.

公开(公告)号：US20190284321A1

公开(公告)日：2019-09-19

申请号：US16318649

申请日：2017-06-17

Applicant: North Carolina State University

Inventor： Michael Leonard Heller ,  Ruben G. Carbonell

IPC: C08F283/02 ,  B01J41/20 ,  B01J41/14 ,  B01J41/13 ,  B01J39/26 ,  B01J39/19 ,  B01J39/20 ,  C07K1/18 ,  B01D71/78 ,  B01D71/26 ,  B01D71/40 ,  B01D67/00 ,  B01D15/20 ,  B01D15/36

Abstract: The invention provides methods for preparing a polymer-grafted and functionalized nonwoven membrane adapted for use in separation processes. The invention further provides so-formed membranes as well as improved separation methods utilizing the membranes. The polymer-grafted and functionalized nonwoven membranes are particularly formed utilizing thermal grafting. In particular, an acrylate or methacrylate polymer can be grafted onto a nonwoven web comprising a plurality of polymeric fibers to form a plurality of polymer segments covalently attached to the polymeric fibers. Thermal grafting particularly can comprise using a thermal initiator and exposing the nonwoven web to heat to initiate polymerization of the acrylate or methacrylate monomer. The grafted polymeric fibers can be functionalized to attach at least one functional group adapted for binding to a target molecule to the polymer segments of the grafted polymeric fibers.

公开(公告)号：US10401334B2

公开(公告)日：2019-09-03

申请号：US13549699

申请日：2012-07-16

Applicant: Hiroshi Ohashi ,  Tadayuki Yamaguchi ,  Hidetoshi Terada

Inventor： Hiroshi Ohashi ,  Tadayuki Yamaguchi ,  Hidetoshi Terada

IPC: G01N30/34 ,  G01N30/86 ,  G01N30/88 ,  B01D15/20

Abstract: The present invention aims at reducing the time required for a series of analyses in the sequential performance of gradient analyses under a variety of conditions. To this end, in a control apparatus for controlling the operation of a liquid chromatograph having a gradient analysis function in which a mobile phase composed of a plurality of mixed solvents is used and a chromatograph analysis is performed while the mixture ratio of the solvents is temporally changed, the liquid chromatograph is controlled so as to continuously change the mixture ratio of the solvents from an initial mixture ratio to a final mixture ratio when performing a sample analysis; and as to perform, before the sample analysis, a preparatory liquid supply in which the mixture ratio of the solvents is continuously changed from the initial mixture ratio to the final mixture ratio at a rate higher than that in the sample analysis.

公开(公告)号：US20190248850A1

公开(公告)日：2019-08-15

申请号：US16275467

申请日：2019-02-14

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Nathan L. MAO ,  Scott CARVER ,  Bernhard SCHILLING ,  Eric SHIERLY

IPC: C07K14/475 ,  G01N30/86 ,  G01N30/56 ,  G01N30/74 ,  B01D15/36 ,  B01D15/32 ,  B01D15/20 ,  B01D15/42 ,  B01D15/38 ,  C07K1/16

CPC classification number: C07K14/475 ,  B01D15/206 ,  B01D15/327 ,  B01D15/363 ,  B01D15/3804 ,  B01D15/424 ,  C07K1/16 ,  G01N30/56 ,  G01N30/74 ,  G01N30/8651 ,  G01N30/8675 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/562 ,  G01N2030/889

Abstract: The disclosure provides systems and methods useful for predicting or detecting a malfunction in a chromatography process in real-time. In some embodiments, the disclosure provides systems and methods for detecting an atypical profile in a process chromatogram in ion-exchange chromatography of a biologic product.

公开(公告)号：US20190224399A1

公开(公告)日：2019-07-25

申请号：US16369817

申请日：2019-03-29

Applicant: Medtronic, Inc.

Inventor： Kenneth J. Collier ,  Christopher M. Hobot ,  Martin T. Gerber ,  Bryant J. Pudil

IPC: A61M1/16 ,  A61M1/36 ,  B01D15/20

Abstract: The invention relates to devices, systems, and methods for recharging zirconium phosphate. The devices, system, and methods use a patient pre-dialysis BUN level to set one or more recharge parameters for recharging the zirconium phosphate. The devices, systems, and methods allow for precision recharging of the zirconium phosphate based on the patient pre-dialysis BUN level.