公开(公告)号：US11154712B2

公开(公告)日：2021-10-26

申请号：US15506740

申请日：2015-08-28

申请人： Medtronic Ardian Luxembourg S.a.r.l.

发明人： Carol Sullivan ,  Stefan Tunev

IPC分类号： A61B5/00 ,  A61B5/20 ,  A61B10/00 ,  A61N1/36 ,  A61N1/05 ,  A61B18/14 ,  A61B18/00 ,  G01N33/493 ,  G01N33/53 ,  G01N33/94 ,  G01N33/74 ,  A61B5/0538 ,  A61B5/145 ,  A61B5/24

摘要： Provided herein are methods, devices and compositions for assessing neuromodulation efficacy based on changes in the level of one or more biomarkers in plasma or urine collected from a human subject following a renal neuromodulation procedure.

公开(公告)号：US20210284753A1

公开(公告)日：2021-09-16

申请号：US17094646

申请日：2020-11-10

申请人： Genentech, Inc.

发明人： Luc Desnoyers

IPC分类号： C07K16/40 ,  C07K14/71 ,  G01N33/74 ,  G01N33/574 ,  A61K31/506 ,  A61K31/4745 ,  A61K31/4196 ,  A61K45/06 ,  A61K31/138 ,  A61K38/17 ,  A61K31/5685 ,  A61K31/565 ,  A61K31/517 ,  A61K31/475 ,  A61K39/395 ,  G01N33/50

摘要： The invention concerns uses of anti-KLβ agents, and detection of KLβ and/or FGF19 and/or FGFR4.

公开(公告)号：US11112414B2

公开(公告)日：2021-09-07

申请号：US14895076

申请日：2014-06-06

申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Universite Paul Sabatier Toulouse III ,  Centre Hospitalier Universitaire de Toulouse

发明人： Philippe Rouet ,  Fatima Smith-Rouet ,  Franck Desmoulin ,  Michel Galinier

IPC分类号： G01N33/53 ,  G01N33/68 ,  G01N33/74

摘要： The invention is a method for treating a heart failure patient with the steps of measuring the concentration of IGFBP2 in a blood, plasma or urine sample obtained from the heart failure patient and comparing the patient's IGFBP2 level to a threshold value derived from IGFBP2 measured in samples taken from a group of patients with heart failure selected from the group consisting of stage I, stage stage III and stage IV heart failure, according to New York Heart Association (NYHA) classification system. A patient with an IGFBP2 level that exceeds the threshold value is admitted or readmitted to a hospital and treated with at least one treatment selected from the group consisting of administration of a beta-blocker, an angiotensin-converting enzyme inhibitor, an angiotensin receptor blocker, an aldosterone antagonist, an implantable cardiac defibrillator, a cardiac resynchronization therapy, an implantable left ventricular assist device and a heart transplant.

公开(公告)号：US11105819B2

公开(公告)日：2021-08-31

申请号：US16752360

申请日：2020-01-24

申请人： CRIMSON U.S. ASSETS LLC

发明人： Ute Schellenberger ,  Eric E. Niederkofier ,  Urban A. Kiernan ,  Jessica O'Rear ,  Randall W. Nelson

IPC分类号： G01N33/74 ,  G01N1/28

摘要： Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.

公开(公告)号：US11099198B2

公开(公告)日：2021-08-24

申请号：US16595035

申请日：2019-10-07

申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

发明人： Zhaohui Chen ,  Nigel Clarke

IPC分类号： G01N33/74 ,  G01N33/66 ,  G01N33/49 ,  G01N33/68 ,  H01J49/00

摘要： Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

公开(公告)号：US20210231688A1

公开(公告)日：2021-07-29

申请号：US17158079

申请日：2021-01-26

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： Sylvie Breton ,  Dennis Brown ,  Anie Azroyan ,  Virna F. Cortez-Retamozo ,  Mikael Pittet

IPC分类号： G01N33/74 ,  G01N33/53 ,  G01N33/566 ,  G01N33/66 ,  A61K31/451 ,  C07K16/28

摘要： The present disclosure relates to assays and methods for the detection of renal inflammation by measuring the level of P2Y14 and/or UDP-glucose in a sample from a subject, such as a urine sample. The present disclosure also relates to methods for the treatment of renal inflammation by administering a P2Y14 inhibitor.

公开(公告)号：US11067586B2

公开(公告)日：2021-07-20

申请号：US15344784

申请日：2016-11-07

申请人： SPHINGOTEC GMBH

发明人： Andreas Bergmann

IPC分类号： G01N33/53 ,  G01N33/74

摘要： Subject of the present invention is an in vitro method for therapy follow-up in septic patients wherein the concentration of mature ADM 1-52 and/or mature ADM 1-52-Gly in a sample of bodily fluid of said septic patient is determined using an assay comprising two binders that bind to two different regions within the region of mature adrenomedullin and/or adrenomedullin-Gly that is aminoacid 21-52-amid SEQ ID No. 1 or aminoacid 21-52-Gly SEQ ID No. 2 wherein each of said regions comprises at least 4 or 5 amino acids. The invention further relates to assays and calibration methods.

公开(公告)号：US11061026B2

公开(公告)日：2021-07-13

申请号：US16732823

申请日：2020-01-02

申请人： MFB Fertility, Inc.

发明人： Amy Beckley

IPC分类号： G01N33/558 ,  G01N33/74 ,  G01N21/64 ,  G01N33/68 ,  G01N33/76

摘要： Disclosed herein are devices, systems, methods and kits for performing immunoassay tests to detect for at least progesterone or analytes of progesterone on a sample in association with diagnosing problems and issues associated with corpus luteum functionality. The immunoassay devices and methods may be used in conjunction with diagnostic reader systems and/or a base unit for obtaining a sensitive read-out of the immunoassay results. The immunoassay devices and methods may utilize a competitive binding-like assay and a sandwich binding assay to detect at least progesterone or analytes of progesterone in a sample.

公开(公告)号：US20210172938A1

公开(公告)日：2021-06-10

申请号：US17119410

申请日：2020-12-11

申请人： Progenity, Inc.

发明人： Pankaj OBEROI ,  Sharat SINGH ,  Amin MAZLOOM

IPC分类号： G01N33/537 ,  G01N33/68 ,  G01N33/74

摘要： Described herein are methods, compositions, kits, and systems for detecting free and bound PlGF, and using detection of such species to distinguish between pregnant women with or without preeclampsia or related conditions.

公开(公告)号：US20210148937A1

公开(公告)日：2021-05-20

申请号：US17153200

申请日：2021-01-20

申请人： ASTUTE MEDICAL, INC.

发明人： JOSEPH ANDERBERG ,  JEFF GRAY ,  PAUL MCPHERSON ,  KEVIN NAKAMURA ,  JAMES PATRICK KAMPF

IPC分类号： G01N33/68 ,  G01N33/74

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Tumor necrosis factor receptor superfamily member 8, Alpha-Fetoprotein, Thyroxine-binding globulin, Prostate-specific antigen (free form), Apolipoprotein A, Apolipoprotein E, Thyrotropin subunit beta, Platelet-derived growth factor B/B dimer, C-C motif chemokine 7, C-C motif chemokine 26, Complement C4-B, Corticotropin, Interferon alpha-2, Interleukin-4 receptor alpha chain, Insulin-like growth factor-binding protein 4, Insulin-like growth factor-binding protein 5, Interleukin 21, Interleukin 23 alpha subunit, Interleukin-28A, Interleukin-33, Lutropin subunit beta, Matrix Metalloproteinase-1, Neural cell adhesion molecule 1, Pigment epithelium-derived factor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 3, and IgG4 as diagnostic and prognostic biomarkers in renal injuries.