公开(公告)号：US06608051B1

公开(公告)日：2003-08-19

申请号：US09522811

申请日：2000-03-10

申请人： James C. Costin

发明人： James C. Costin

IPC分类号： A61K3154

CPC分类号： A61K31/54

摘要： A blood collection system and method are disclosed in which taurolidine, a neutralizing agent for pathogens is added to the blood collected in standard blood bags. The taurolidine agent may be prepositioned in the collection bag prior to the collection of blood or alternatively the taurolidine may be added after the collection of blood has been completed.

摘要翻译： 公开了一种采血系统和方法，其中将taurolidine（一种用于病原体的中和剂）加入到标准血袋中收集的血液中。 在收集血液之前，可以将taurolidine试剂置于收集袋中，或者可以在血液收集完成后添加taurolidine。

公开(公告)号：US06525100B1

公开(公告)日：2003-02-25

申请号：US09721439

申请日：2000-11-22

申请人： W. Jerry Easterling ,  William P. Fitch, III

发明人： W. Jerry Easterling ,  William P. Fitch, III

IPC分类号： A61K3154

CPC分类号： A61K31/135

摘要： The invention is of a topical medicament and associated methodology for use thereof, through the use of which Peyronie's disease may be effectively, cost effectively, and painlessly treated. The primary active ingredient is a calmodulin blocker, the preferred such ingredient being trifluroperizine.

摘要翻译： 本发明是通过使用Peyronie氏病可以有效地，成本有效地和无痛地治疗的局部药物及其相关使用方法。 主要活性成分是钙调蛋白阻断剂，优选的这种成分是三腮麻素。

公开(公告)号：US06521617B2

公开(公告)日：2003-02-18

申请号：US09977558

申请日：2001-10-15

申请人： Eduardo Marban ,  Brian O'Rourke ,  Masaharu Akao

发明人： Eduardo Marban ,  Brian O'Rourke ,  Masaharu Akao

IPC分类号： A61K3154

CPC分类号： A61K31/54 ,  A61K31/4178 ,  A61K31/4406

摘要： New methods are provided for treating against apoptotic cell death, including apoptotic cardiac and neuronal cells. Therapies of the invention include administration of a mitochondrial oxidizer compound to a subject in need thereof, such as a subject suffering from or susceptible to stroke, heart attack, brain or spinal cord trauma, or chronic conditions that can resulting apoptotic cell death such as a neurodegenerative disease.

公开(公告)号：US06469000B1

公开(公告)日：2002-10-22

申请号：US09649826

申请日：2000-08-29

申请人： Stanislaw Pikul ,  Kelly Lynn McDow-Dunham ,  Neil Gregory Almstead ,  Biswanath De ,  Michael George Natchus ,  Yetunde Olabisi Taiwo

发明人： Stanislaw Pikul ,  Kelly Lynn McDow-Dunham ,  Neil Gregory Almstead ,  Biswanath De ,  Michael George Natchus ,  Yetunde Olabisi Taiwo

IPC分类号： A61K3154

CPC分类号： C07D239/10 ,  C07D233/02 ,  C07D233/38 ,  C07D239/04 ,  C07D243/04 ,  C07D265/06 ,  C07D265/14 ,  C07D277/06 ,  C07D279/06 ,  C07D409/14 ,  C07D413/14 ,  C07D487/04 ,  C07D495/10

摘要： Disclosed are compounds which are inhibitors of metalloproteases having the following structure: where Ar, W, X, Y, Z, R1 and R2 have the meanings described in the specification and optical isomers, diastereomers, and enantiomers thereof or a pharmaceutically-acceptable salt, or biohydrolyzable amides, esters, or imides thereof. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by unwanted metalloprotease activity using these compounds or pharmaceutical compositions.

公开(公告)号：US06429206B2

公开(公告)日：2002-08-06

申请号：US09781108

申请日：2001-02-09

申请人： Hubert Dorn ,  Terence Hopkins

发明人： Hubert Dorn ,  Terence Hopkins

IPC分类号： A61K3154

CPC分类号： A01N61/00 ,  A01N51/00 ,  Y10S514/875 ,  Y10S514/876 ,  A01N2300/00

摘要： Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for the non-systemic control of parasitic insects, such as fleas, lice and flies, on humans and on animals.

公开(公告)号：US06423707B1

公开(公告)日：2002-07-23

申请号：US09650027

申请日：2000-08-28

申请人： Li-Xi Yang ,  Hui-Juan Wang ,  Xiandao Pan

发明人： Li-Xi Yang ,  Hui-Juan Wang ,  Xiandao Pan

IPC分类号： A61K3154

CPC分类号： C07D401/12 ,  C07D233/94 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D491/04

摘要： Novel nitroimidazole compounds are provided that have a substituent linked via an ester linkage. The ester linkage may be obtained by derivation of the hydroxyl group of metronidazole. These nitroimidazole ester analogs have anti-microbial activity, with a number of novel compounds having an anti-microbial activity that is significantly improved with respect to metronidazole. Two particularly preferred embodiments are shown by Formulas 4 and 5 below:

摘要翻译： 提供了具有通过酯键连接的取代基的新型硝基咪唑化合物。 酯键可以通过衍生甲硝唑的羟基来获得。 这些硝基咪唑酯类似物具有抗微生物活性，许多具有相对于甲硝唑显着改善的抗微生物活性的新化合物。 两个特别优选的实施方案由下式4和5表示：

公开(公告)号：US06420361B1

公开(公告)日：2002-07-16

申请号：US09663039

申请日：2000-09-15

申请人： George B. Baker ,  Jimmie D. Petty ,  Richard M. Schwarz

发明人： George B. Baker ,  Jimmie D. Petty ,  Richard M. Schwarz

IPC分类号： A61K3154

CPC分类号： A01N43/88 ,  A01N41/10 ,  A01N37/18 ,  A01N29/02 ,  A01N25/02 ,  A01N2300/00

摘要： A liquid soil pesticide composition containing tetrahydro-3,5-dimethyl-2H-1,3,5-thiadiazine-2-thione. The composition contains 1,3-dichloropropene as a first co-solvent and a second co-solvent selected from the group consisting of dimethyl sulfoxide and dimethylformamide.

摘要翻译： 含有四氢-3,5-二甲基-2H-1,3,5-噻二嗪-2-硫酮的液体土壤农药组合物。 组合物含有作为第一助溶剂的1,3-二氯丙烯和选自二甲基亚砜和二甲基甲酰胺的第二共溶剂。

公开(公告)号：US06395730B1

公开(公告)日：2002-05-28

申请号：US09689808

申请日：2000-10-13

申请人： Michael F. Gross ,  Neil A. Castle ,  Jose S. Mendoza

发明人： Michael F. Gross ,  Neil A. Castle ,  Jose S. Mendoza

IPC分类号： A61K3154

CPC分类号： C07D417/04 ,  A61K31/425 ,  A61K31/54 ,  C07D277/14 ,  C07D279/06

摘要： Certain thiazolidinone and metathiazanone compounds, as described, are useful as potassium channel inhibitors and are especially useful for the treatment of cardiac arrhythmias and other diseases, conditions and disorders.

摘要翻译： 如所述，某些噻唑烷酮和偏二氮烯酮化合物可用作钾通道抑制剂，并且特别可用于治疗心律失常和其它疾病，病症和障碍。

公开(公告)号：US06365586B1

公开(公告)日：2002-04-02

申请号：US09420347

申请日：1999-10-19

申请人： Lone Jeppesen ,  Paul Stanley Bury ,  Per Sauerberg

发明人： Lone Jeppesen ,  Paul Stanley Bury ,  Per Sauerberg

IPC分类号： A61K3154

CPC分类号： C07D471/14 ,  C07D491/14 ,  C07D495/14

摘要： The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).

公开(公告)号：US06346530B1

公开(公告)日：2002-02-12

申请号：US09366986

申请日：1999-08-04

申请人： Jitendra Krishan Somani ,  Indu Bhushan ,  Himadri Sen

发明人： Jitendra Krishan Somani ,  Indu Bhushan ,  Himadri Sen

IPC分类号： A61K3154

CPC分类号： A61K31/546

摘要： This invention relates to a process of mixing of crystalline cefuroxime axetil with amorphous cefuroxime axetil for the preparation of a bioavailable oral dosage form comprising of amorphous cefuroxime axetil containing from 7 to 25% crystalline cefuroxime axetil.

摘要翻译： 本发明涉及将结晶头孢呋辛酯与无定形头孢呋辛酯酯混合以制备包含7-25％结晶头孢呋辛酯的无定形头孢呋辛酯的生物可利用口服剂型的方法。