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    Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same
    75.
    发明授权
    Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same 失效
    具有黄体激素释放激素活性的合成十肽及其制造方法

    公开(公告)号：US3953416A

    公开(公告)日：1976-04-27

    申请号：US432903

    申请日：1974-01-14

    Applicant: Karl Folkers ,  Bruce L. Currie ,  Jaw-Kang Chang ,  Hans Sievertsson ,  Conny Bogentoft

    Inventor： Karl Folkers ,  Bruce L. Currie ,  Jaw-Kang Chang ,  Hans Sievertsson ,  Conny Bogentoft

    IPC: A61K38/00 ,  C07K5/103 ,  C07K7/23 ,  C07C103/52 ,  C07G7/00

    CPC classification number: C07K5/1005 ,  C07K7/23 ,  A61K38/00 ,  Y10S514/80 ,  Y10S930/13

    Abstract: A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide which has the hormonal activities of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is produced by utilizing as the key starting materials, the amino acids, glutamic acid or pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, and proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate combinations of appropriate protected forms of the amino acids, and finally deprotecting to yield the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide.

    Abstract translation: 具有黄体生成激素释放激素的激素活性的合成十肽L- L-谷氨酰-L-组氨酰-LL-色氨酰-L-丝氨酰-L-酪氨酰 - 甘氨酰-L-赖氨酸-L-精氨酰-L-脯氨酰甘氨酰胺 通过利用氨基酸，谷氨酸或焦谷氨酸，组氨酸，色氨酸，丝氨酸，酪氨酸，甘氨酸，亮氨酸，精氨酸和脯氨酸的关键起始物质产生哺乳动物下丘脑的LRH）。 十肽的合成通过以合适的保护形式的氨基酸的适当组合偶联，最后脱保护得到酰胺，L-谷氨酰基-L-组氨酰基-L-色氨酸-L-丝氨酰-L-酪氨酰 - 甘氨酰基 -L-赖氨酸-L-精氨酰-L-脯氨酰基 - 甘氨酰胺。

    Hypocalcaemically active peptides related to human calcitonin
    76.
    发明授权
    Hypocalcaemically active peptides related to human calcitonin 失效
    与人类降钙素相关的低活性活性肽

    公开(公告)号：US3910872A

    公开(公告)日：1975-10-07

    申请号：US45314874

    申请日：1974-03-20

    Applicant: CIBA GEIGY CORP

    Inventor： RINIKER BERNHARD ,  RITTEL WERNER

    IPC: C07K14/575 ,  A61K38/00 ,  C07K5/103 ,  C07K14/00 ,  C07K14/585 ,  C07C103/52 ,  A61K37/00

    CPC classification number: C07K5/1005 ,  A61K38/00 ,  C07K14/585 ,  Y10S514/808

    Abstract: The new hypocalcaemic peptides of the formula

    wherein X represents the L-methionine, L-valine, L-norvaline, Lleucine, L-isoleucine, L-norleucine or L- Alpha -aminobutyric acid radical, above all the L-methionine or L-valine radical, and wherein L-alanine26 is replaced by L-asparagine and/or Lisoleucine27 is replaced by L-threonine, and wherein optionally one or more of the aminoacids in positions 11, 12, 16, 19, 22 and 24 is or are replaced by another aminoacid, namely L-threonine11 by L-lysine, L-tyrosine12 by L-leucine, L-phenylalanine16 by Lleucine, L-phenylalanine19 by L-leucine, L-phenylalanine22 by Ltyrosine and L-glutamine24 by L-arginine.

    Abstract translation: 式1234567891011 H-Cys-Gly-Asn-Leu-Ser-Thr-Cys-X-Leu-Gly-Thr-1213141516171819202122 Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His的新型低钙血症肽 -Thr-Phe-23242526272829303132 Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2，其中X表示L-甲硫氨酸，L-缬氨酸，L-正缬氨酸，L-亮氨酸， 异亮氨酸，L-正亮氨酸或L-α-氨基丁酸根，最重要的是L-甲硫氨酸或L-缬氨酸基，其中L-丙氨酸26被L-天冬酰胺代替，和/或L-异亮氨酸27被L-苏氨酸替代， 其中任选地，11,12,16,19,22和24位中的一个或多个氨基酸被另一个氨基酸所取代，即L-赖氨酸的L-苏氨酸11，L-亮氨酸的L-酪氨酸12，L-苯丙氨酸16 L-亮氨酸，L-亮氨酸的L-苯丙氨酸19，L-酪氨酸的L-苯丙氨酸22和L-精氨酸的L-谷氨酰胺24。

    Intermediates in the preparation of secretin
    78.
    发明授权
    Intermediates in the preparation of secretin 失效
    制备分泌物的中间体

    公开(公告)号：US3812092A

    公开(公告)日：1974-05-21

    申请号：US8251070

    申请日：1970-10-20

    Applicant: SQUIBB & SONS INC

    Inventor： BODANSZKY M ,  NARAYANAN V ,  LEVINE S ,  ONDETTI M ,  VON SALTZA M

    IPC: A61K38/00 ,  C07K5/072 ,  C07K5/103 ,  C07K5/117 ,  C07K14/645 ,  C07C103/52

    CPC classification number: C07K5/1005 ,  A61K38/00 ,  C07K5/06095 ,  C07K5/1024 ,  C07K14/645

    Abstract: THIS INVENTION RELATES TO INTERMEDIATES AND THEIR SALTS USEFUL IN THE PREPARATION OF THE GASTROINTESTINAL HORMONE, SECRETIN. THE INTERMEDIATES OF THIS INVENTION COMPRISE PARTIAL SEQUENCES OF AMINO ACIDS, WHICH, WHEN COMBINED, FORM THE SECRETIN MOLECULE. THE NOVEL PROTECTIVE PEPTIDES CORRESPONDING TO THESE PARTIAL SEQUENCES ARE: (1) PROTECTED L-HISTIDYL-L-SERYL-L-ASPARTGLYGLYCINE; (AMINO ACIDS 1 TO 4); (2) PROTECTED L-THREONYL-L-PHENYLALANYL-L-THREONYL-L SERINE HYDRAZIDE; (AMINO ACIDS 5 TO 8); (3) PROTECTED L-GLUTAMYL-L-LEUCYL-L-SERYL-L-ARGINYL-LLEUCINE HYDRAZIDE; (AMINO ACIDS 9 TO 13); AND (4) PROTECTED L-ARGINYL-L-ASPARTYL-L-SERYL-L-ALANYL-LARGINYL-L-LEUCYL-L-GLUTAMINYL-L -ARGINYL-L-LEUCY-LGLUTAMINYLGLYCYL-L-LEUCYL-L-VALINAMIDE; (AMINO ACIDS 14 TO 27).

    Polypeptide
    79.
    发明授权
    Polypeptide 失效
    聚氨酯

    公开(公告)号：US3761459A

    公开(公告)日：1973-09-25

    申请号：US3761459D

    申请日：1966-07-20

    Applicant: SANDOZ LTD

    Inventor： PLESS J ,  GUTTMANN S ,  BOISSONNAS R

    IPC: A61K38/00 ,  C07K5/09 ,  C07K5/103 ,  C07K14/695 ,  C07C103/52 ,  C07G7/00

    CPC classification number: C07K5/1005 ,  A61K38/00 ,  C07K5/0815 ,  C07K14/695 ,  Y02P20/55 ,  Y10S514/805

    Abstract: THE INVENTION DESCRIBES A NEW PENTACOSAPEPTIDE OF THE FORMULA. D-SERYL-L-TYROSYL-L-SERYL-L-NORLEUCYL-L-GLUTAMYL-L-HISTIDYL-L-PHENYLALANYL-L-ARGINGYL-L-TRYPTOPHANYLGLYCYL-L-LYSYL-L-PROLYL-L-VALYL-GLYCYL-L-LYSYL-L -LYSYL-LARGINYL-L-ARGINYL-L-PROLYL-L-VALYL-L-HYSYL-L-VALYL-LTYROSYL-L-PROLYL-L-VALINAMIDE, ITS THERAPEUTICALLY ACTIVE ACID ADDITION SALTS AND HEAVY METAL COMPLEXES. THE POLYPEPTIDE OF THE INVENTION, ALSO NAMED D-SER1-NIE4-VALNH2**25A1**25-ACTH, IS PHARMACEUTICALLY USEFUL BECAUSE OF ITS HIGH ADRENOCORITCOTROPIC EFFECT.

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