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    Sulfonamide and sulfamide substituted imidazoquinolines
    71.
    发明授权
    Sulfonamide and sulfamide substituted imidazoquinolines 有权
    磺酰胺和磺酰胺取代的咪唑并喹啉

    公开(公告)号：US07199131B2

    公开(公告)日：2007-04-03

    申请号：US11101369

    申请日：2005-04-07

    Applicant: Kyle J. Lindstrom

    Inventor： Kyle J. Lindstrom

    IPC: A61K31/44

    CPC classification number: A61K31/4745 ,  C07D471/04 ,  Y02A50/409

    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

    Abstract translation: 在1位含有磺酰胺或磺酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫反应调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

    Urea substituted imidazopyridines
    74.
    发明授权
    Urea substituted imidazopyridines 失效
    脲取代的咪唑并吡啶

    公开(公告)号：US06903113B2

    公开(公告)日：2005-06-07

    申请号：US10771639

    申请日：2004-02-04

    Applicant: Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

    Inventor： Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

    IPC: C07D471/04 ,  A61K31/437

    CPC classification number: C07D471/04

    Abstract: Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

    Abstract translation: 在1位含有脲或硫脲官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

    Imidazonaphthyridines
    78.
    发明授权
    Imidazonaphthyridines 有权
    咪唑并萘啶

    公开(公告)号：US06624172B2

    公开(公告)日：2003-09-23

    申请号：US09945197

    申请日：2001-08-31

    Applicant: Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

    Inventor： Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

    IPC: A61K31417

    CPC classification number: C07D471/04 ,  A61K31/4745 ,  A61K45/06 ,  C07D471/14 ,  A61K2300/00

    Abstract: Imidazonaphthydrine compounds that have an aryl containing substituent at the 1-position induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

    Abstract translation: 在1位具有含芳基取代基的咪唑并噻吩类化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 还公开了制备可用于制备化合物的化合物和中间体的方法。

    BENZYL (METH)ACRYLATE MONOMERS SUITABLE FOR MICROSTRUCTURED OPTICAL FILMS
    80.
    发明申请
    BENZYL (METH)ACRYLATE MONOMERS SUITABLE FOR MICROSTRUCTURED OPTICAL FILMS 有权
    适用于微结构光学膜的苄基（甲基）丙烯酸酯单体

    公开(公告)号：US20140058038A1

    公开(公告)日：2014-02-27

    申请号：US13985058

    申请日：2012-04-25

    Applicant: Bryan V. Hunt ,  Kyle J. Lindstrom ,  Maureen C. Nelson

    Inventor： Bryan V. Hunt ,  Kyle J. Lindstrom ,  Maureen C. Nelson

    IPC: G02B1/04

    CPC classification number: G02B1/04 ,  C08F220/18 ,  C08J7/16 ,  C09D133/06

    Abstract: Presently described are optical films comprising a polymerized (e.g. microstructured) surface that comprises the reaction product of a polymerizable resin composition and polymerizable resin compositions that comprise nanoparticles; at least one first monomer comprising at least two (meth)acrylate groups; and at least one second (meth)acrylate monomer having following the structure (I); wherein at least one R1 comprises an aromatic substituent, t is an integer from 1 to 4, and R2 is hydrogen or methyl.

    Abstract translation: 目前描述的是包含聚合（例如微结构化）表面的光学膜，其包含可聚合树脂组合物和包含纳米颗粒的可聚合树脂组合物的反应产物; 至少一种包含至少两个（甲基）丙烯酸酯基团的第一单体; 和具有以下结构（I）的至少一种第二（甲基）丙烯酸酯单体; 其中至少一个R 1包含芳族取代基，t是1至4的整数，并且R 2是氢或甲基。

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