公开(公告)号：US07915587B2

公开(公告)日：2011-03-29

申请号：US12435148

申请日：2009-05-04

申请人： John Francis Federici

发明人： John Francis Federici

IPC分类号： G21K1/00

CPC分类号： H04B10/00 ,  G01J3/0205 ,  G01J3/12 ,  G02B6/12004

摘要： Rapid, voltage controlled phase modulation of continuous wave THz radiation is demonstrated. By transmitting an infrared laser beam through a phase modulator, the phase of the THz radiation which is generated by the photomixing of two infrared beams can be directly modulated through a 2π phase shift. The 100 kHz modulation rate that is demonstrated is approximately three orders of magnitude faster than what can be achieved by mechanical scanning.

摘要翻译： 证明了连续波太赫兹辐射的快速，电压控制相位调制。 通过发射红外激光束通过相位调制器，通过两个红外光束的光混合产生的THz辐射的相位可以通过2＆pgr直接调制。 相移。 证明的100kHz调制速度比通过机械扫描可以实现的速度快约三个数量级。

公开(公告)号：US20110071800A1

公开(公告)日：2011-03-24

申请号：US12566509

申请日：2009-09-24

申请人： Saravanan Sethuraman ,  John Francis Mullen

发明人： Saravanan Sethuraman ,  John Francis Mullen

IPC分类号： G06F17/50

CPC分类号： G06F17/5022 ,  G06F17/5045

摘要： A system and method for providing schematic reviews is provided. The method includes providing a schematic design, selecting a signal, where the signal is a graphical representation, previewing the signal, obtaining relevant information on components constituting the signal, and controlling the signal to obtain relevant information on the components. Controlling the signal comprises activating a link to a data compilation related to the signal component, and activating the data compilation comprises creating a link to a datasheet. The graphic representation of the signal comprises providing a block diagram overview of connectivity of the signal components and the graphical representation comprises a graphical three dimensional model, and providing a log database that includes review information provided by multiple reviewers and is accessible by the reviewers. A notation medium is provided for the reviewers for communication between the reviewers.

摘要翻译： 提供了一种用于提供示意图评估的系统和方法。 该方法包括提供示意性设计，选择信号，其中信号是图形表示，预览信号，获得关于组成信号的组件的相关信息，以及控制信号以获得关于组件的相关信息。 控制信号包括激活与信号分量相关的数据汇编的链接，并且激活数据编译包括创建到数据表的链接。 信号的图形表示包括提供信号分量的连接性的框图，图形表示包括图形三维模型，以及提供包括由多个审阅者提供的审阅信息并且可由审阅者访问的日志数据库。 为审阅者提供了一种记录介质，用于审阅者之间的通信。

公开(公告)号：US07906975B2

公开(公告)日：2011-03-15

申请号：US11965045

申请日：2007-12-27

申请人： John Francis Federici ,  Rose M. Federici

发明人： John Francis Federici ,  Rose M. Federici

IPC分类号： G01N21/88 ,  G01N21/17

CPC分类号： G01N21/3581 ,  G01N21/3563 ,  G01N21/4795 ,  G01N21/909 ,  G01N21/94 ,  G01N21/95 ,  G01N33/146

摘要： Non-invasive THz spectroscopic apparatus and methods are provided for detecting and/or identifying constituents such as variations in a structural entity where chemical or biological entities can reside. Position dependent scattering of THz radiation is employed to image voids and defects in the internal structure of samples, enabling the determination of contamination, spoilage or readiness of products such as wine in sealed containers.

摘要翻译： 提供了非侵入性的THz光谱仪器和方法，用于检测和/或识别诸如化学或生物实体可以驻留的结构实体中的变化的成分。 采用THz辐射的位置相关散射来对样品内部结构中的空隙和缺陷进行成像，从而可以确定密封容器中葡萄酒等产品的污染，变质或准备状态。

公开(公告)号：US20110046182A1

公开(公告)日：2011-02-24

申请号：US12808693

申请日：2008-12-19

申请人： John Francis Gilmer ,  Louise Clune-Moriarty ,  Maeve Lally

发明人： John Francis Gilmer ,  Louise Clune-Moriarty ,  Maeve Lally

IPC分类号： A61K31/443 ,  C07D493/04 ,  C07D261/02 ,  C07D285/06 ,  C07D405/12 ,  A61K31/34 ,  A61K31/422 ,  A61K31/433 ,  A61P25/28 ,  A61P9/00 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D493/04

摘要： Aspirin is one of the most widely used drugs in the treatment of inflammation, pain and fever. It has more recently found application in the prevention of heart attacks and stroke and is being studied as a cancer chemopreventative agent. Despite its value aspirin continues to be underutilized because it causes gastric bleeding. The technology under development potentially removes this problem. It is designed to reduce contact between the drug and the intestinal lining. An isosorbide aspirinate prodrug compound is thus provided. The compound has the general structure as shown in general formula (I) wherein Y is a C1-C8 alkyl ester, a C1-C8 alkoxy ester, a C3-C10 cycloalkyl ester, an arylester, a C1-C8 alkylaryl ester or —C(O)ORring, wherein Rring is a 5-membered aromatic or nonaromatic 5-member ring having at least one heteroatom substituted for a carbon of the ring system, which can be unsubstituted or substituted with at least one nitric oxide releasing group.

摘要翻译： 阿司匹林是治疗炎症，疼痛和发烧最广泛使用的药物之一。 最近发现应用于预防心脏病发作和中风，并正在研究中作为癌症化学预防剂。 尽管阿司匹林的价值仍然不足，因为它导致胃出血。 正在开发的技术可能会消除这个问题。 它旨在减少药物和肠内膜之间的接触。 因此提供了异山梨醇阿司匹林前药化合物。 该化合物具有通式（I）所示的一般结构，其中Y为C1-C8烷基酯，C1-C8烷氧基酯，C3-C10环烷基酯，芳基酯，C1-C8烷基芳基酯或-C （O）ORring，其中Rring是具有至少一个取代环系的碳的杂原子的5元芳族或非芳族5元环，其可以是未取代的或被至少一个一氧化氮释放基团取代。

公开(公告)号：US20110029330A1

公开(公告)日：2011-02-03

申请号：US12534419

申请日：2009-08-03

申请人： John Francis Paddock, III ,  Wesley Forrest Sprinkle ,  Celeste M. Neilsen ,  Wendell Bruce Lund, III ,  Sandra J. Meyerhofer

发明人： John Francis Paddock, III ,  Wesley Forrest Sprinkle ,  Celeste M. Neilsen ,  Wendell Bruce Lund, III ,  Sandra J. Meyerhofer

IPC分类号： G06Q40/00

CPC分类号： G06Q40/00 ,  G06Q40/08

摘要： According to some embodiments, a plurality of new work notifications are received, each associated with a producer identifier. A set of non-appointed new work notifications may be determined, including a first non-appointed new work notification and a second non-appointed new work notification, the second non-appointed new work notification being received after the first non-appointed new work notification, and at least some of the non-appointed new work notifications may be automatically prioritized such that the second new work notification is assigned a higher priority as compared to the first new work notification. It may then be arranged for a manual appointment processing procedure to be performed for at least some of the non-appointed new work notifications in accordance with the prioritizing.

摘要翻译： 根据一些实施例，接收多个新的工作通知，每个新的工作通知都与生产者标识符相关联。 可以确定一套非指定的新工作通知，包括第一个未指定的新工作通知和第二个未指定的新工作通知，第一个未任命的新工作后收到的第二个未指定的新工作通知 通知，并且至少一些未指定的新工作通知可以被自动优先化，使得与第一新工作通知相比，第二新工作通知被分配更高的优先级。 然后可以根据优先级排列针对至少一些非任命的新工作通知执行手动约定处理过程。

公开(公告)号：US07875025B2

公开(公告)日：2011-01-25

申请号：US11348541

申请日：2006-02-06

申请人： John Francis Cockburn ,  Donald James Alexander Cockburn ,  Simon Wemyss-Holden

发明人： John Francis Cockburn ,  Donald James Alexander Cockburn ,  Simon Wemyss-Holden

IPC分类号： A61B18/14

CPC分类号： A61B8/0841 ,  A61B8/08 ,  A61B8/488 ,  A61B18/1477 ,  A61B2018/0016 ,  A61B2018/1407 ,  A61B2018/1467 ,  A61B2018/1475

摘要： A needle assembly (N) for RF ablation of target tissue in e.g. the liver (L) of a patient comprises a radial array of electrodes (1) in the form of loops which can be expanded by feeding the proximal ends of the Y electrodes along the bore of the needle assembly. An RF power supply (2) is connection between the array of electrodes and a skin pad (P) in contact with the skin (S) of a patient and, in accordance with the invention, is biased by a DC power supply 4 which generates electro-osmotic and/or electrolytic effects in the target tissue. In particular, chloride ions are discharged to generate chlorine which has a potent cytocidal effect and water can be attracted to the array of electrodes by electro-osmosis, thereby alleviating the problems of low electrical and thermal conductivity encountered with conventional apparatus.

摘要翻译： 用于靶组织的RF消融的针组件（N）。 患者的肝脏（L）包括环形形式的电极（1）的径向阵列，其可以通过沿着针组件的孔馈送Y电极的近端而被扩展。 RF电源（2）是电极阵列和与患者的皮肤（S）接触的皮肤垫（P）之间的连接，并且根据本发明被直流电源4偏置，直流电源4产生 目标组织中的电渗和/或电解效应。 特别地，氯离子被排出以产生具有强的杀细胞效应的氯，并且水可以通过电渗被吸引到电极阵列，从而减轻常规装置遇到的低导热性和导热性的问题。

公开(公告)号：US20110002879A1

公开(公告)日：2011-01-06

申请号：US12752772

申请日：2010-04-01

申请人： Jayne Elizabeth CURRY ,  John Francis LYONS ,  Matthew Simon SQUIRES ,  Neil Thomas THOMPSON ,  Kyla Merriom THOMPSON ,  Paul Graham WYATT ,  Neil James GALLAGHER

发明人： Jayne Elizabeth CURRY ,  John Francis LYONS ,  Matthew Simon SQUIRES ,  Neil Thomas THOMPSON ,  Kyla Merriom THOMPSON ,  Paul Graham WYATT ,  Neil James GALLAGHER

IPC分类号： A61K38/19 ,  A61K31/415 ,  A61K31/4439 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/496 ,  A61K31/4178 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/4155 ,  A61K31/4709 ,  A61K31/422 ,  A61K31/506 ,  A61K31/541 ,  A61K31/4545 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4375 ,  A61K39/395 ,  A61K38/22 ,  A61K31/69 ,  A61K31/665 ,  A61K31/573 ,  A61K31/7076 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/24 ,  A61K31/675 ,  A61K31/7048 ,  A61K38/14 ,  A61K38/18 ,  A61K31/663 ,  A61K31/522 ,  A61P35/00

CPC分类号： A61K45/06 ,  A61K31/415 ,  A61K31/4439 ,  A61K31/497 ,  A61K33/24 ,  A61K2300/00

摘要： The invention provides a combination comprising a cytotoxic compound, a signalling inhibitor, an ancillary agent, or two or more further anti-cancer agents, and a compound having the formula (Ib): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4—; A is a bond, C═O, NRg(C═O) or O(C═O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from fluorine, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).

摘要翻译： 本发明提供了包含细胞毒性化合物，信号传导抑制剂，辅助剂或两种或更多种其它抗癌剂和具有式（Ib）的化合物或其盐或互变异构体或N-氧化物或溶剂合物的组合： 其中X是基团R 1 -A-NR 4 - ; A是键，C = O，NR g（C = O）或O（C = O），其中R g是氢或任选被羟基或C 1-4烷氧基取代的C 1-4烃基; Y是长度为1,2或3个碳原子的键或亚烷基链; R1是具有3-12个环成员的碳环或杂环基; 或任选被一个或多个选自氟，羟基，C 1-4烃氧基，氨基，一或二-C 1-4烃基氨基的取代基取代的C 1-8烃基，以及具有3-12个环成员的碳环或杂环基， 并且其中所述烃基的1或2个碳原子可以任选地被选自O，S，NH，SO，SO 2的原子或基团取代; R2是氢; 卤素; C 1-4烷氧基（如甲氧基）; 或任选被卤素（例如氟），羟基或C 1-4烷氧基（例如甲氧基）取代的C 1-4烃基; R3选自具有3至12个环成员的碳环和杂环基; 和R 4是氢或任选被卤素（例如氟），羟基或C 1-4烷氧基（例如甲氧基）取代的C 1-4烃基。

公开(公告)号：US07849710B2

公开(公告)日：2010-12-14

申请号：US11248652

申请日：2005-10-12

申请人： Paul De Larminat ,  Luc Le Cointe ,  John Francis Judge ,  Satheesh Kulankara

发明人： Paul De Larminat ,  Luc Le Cointe ,  John Francis Judge ,  Satheesh Kulankara

IPC分类号： F25B39/02

CPC分类号： F28F9/0265 ,  F25B39/028 ,  F25B2339/0242 ,  F25B2341/0011 ,  F28D3/02 ,  F28F9/22 ,  F28F13/187

摘要： A falling film evaporator is provided for use in a two-phase refrigeration system or process system. The evaporator includes a shell having an upper portion, a lower portion, and a tube bundle having tubes extending substantially horizontally in the shell. A hood is disposed over the tube bundle, the hood having an upper end adjacent the upper portion above the tube bundle, the upper end having opposed substantially parallel walls extending toward the lower portion, the walls terminating at an open end opposite the upper end. Once liquid refrigerant or liquid refrigerant and vapor refrigerant is deposited onto the tube bundle, the substantially parallel walls of the hood substantially prevent cross flow of refrigerant vapor or liquid and vapor between the tubes of the tube bundle.

摘要翻译： 提供降膜蒸发器用于两相制冷系统或过程系统。 蒸发器包括具有上部，下部和具有在壳中基本水平延伸的管的管束的壳体。 发动机罩设置在管束上方，罩具有邻近管束上方的上部的上端，上端具有朝向下部延伸的相对的基本上平行的壁，壁终止于与上端相对的开口端。 一旦液体制冷剂或液体制冷剂和蒸气制冷剂沉积到管束上，则罩的基本上平行的壁基本上防止制冷剂蒸汽或管束的管之间的液体和蒸气的交叉流动。

公开(公告)号：US20100287953A1

公开(公告)日：2010-11-18

申请号：US12677081

申请日：2008-09-01

申请人： John Francis Urch

发明人： John Francis Urch

IPC分类号： F25D5/00 ,  F25B15/00 ,  F24F7/00

CPC分类号： F24F12/006 ,  F24F1/0007 ,  F28D9/0025 ,  F28D9/0068 ,  Y02B30/545 ,  Y02B30/563

摘要： A heat exchanger is provided having a first path and a second path through which air passes with heat transferred between the two paths. Exterior moist air is delivered to the first path together with a dissolved desiccant. An exothermic reaction takes place with heat transferred to the second path. Moist air passes through the second path with water in the second path being caused to evaporate thereby cooling air passing along the second path.

摘要翻译： 提供一种热交换器，其具有第一路径和第二路径，空气通过该路径与在两条路径之间传递的热量通过。 外部湿润空气与溶解的干燥剂一起送至第一道。 放热反应发生在传递到第二路径的热量中。 潮湿空气通过第二路径，使第二路径中的水蒸发，从而冷却沿着第二路径通过的空气。

公开(公告)号：US20100213929A1

公开(公告)日：2010-08-26

申请号：US12678036

申请日：2008-09-08

申请人： John Francis Gregg ,  Alexy Davison Karenowska

发明人： John Francis Gregg ,  Alexy Davison Karenowska

IPC分类号： G01P3/481 ,  G01B7/30

CPC分类号： F01D11/20 ,  F01D17/02 ,  F01D21/003 ,  G01B7/14 ,  G01P3/48 ,  G01P3/488

摘要： A rotor blade sensor for detecting a rotor blade (430) comprising an electrical oscillator arranged to generate an oscillating signal. An antenna (300) includes a coil (100) having one or two winding layers coupled to the electrical oscillator. The antenna (300) may instead or as well include a coil (100) comprising a plurality of winding layers, each layer being separated by al spacer for substantially reducing inter-layer capacitance, being coupled to the electrical oscillator. The antenna (300) is driven in use by the oscillating signal of the oscillator at substantially a resonant frequency of the antenna (300). The antenna generates an antenna electromagnetic field that interacts with a rotor blade (430) such that the electrical characteristics of the antenna (300) vary as the interaction between the antenna (300) and the rotor blade changes and a detector circuit is arranged to monitor these electrical characteristics.

摘要翻译： 一种用于检测转子叶片（430）的转子叶片传感器，其包括布置成产生振荡信号的电振荡器。 天线（300）包括线圈（100），其具有耦合到电振荡器的一个或两个绕组层。 天线（300）可以代替地或者包括包括多个绕组层的线圈（100），每个层被隔离层分隔开，用于实质上减少层间电容，耦合到电振荡器。 天线（300）在天线（300）的基本上共振频率下被振荡器的振荡信号驱动。 天线产生与转子叶片（430）相互作用的天线电磁场，使得天线（300）的电气特性随着天线（300）和转子叶片之间的相互作用发生变化并且检测器电路被布置成监测 这些电气特性。