摘要:
3-Hydrazino-1,2,8,9-tetraazaphenalenes optionally substituted in the 4, 5, 6, 7 and/or 9 positions and their salts are cardiovascular agents and are prepared from 3-thiono-2,3-dihydro1,2,8,9-tetraazaphenalenes. Representative embodiments are 3hydrazino-1,2,8,9-tetraazaphenalene and 3-hydrazino-9-phenyl1,2,8,9-tetraazaphenalene.
摘要:
A novel 2,6-diphenyl-4,5-dihydro-3(2H)-pyridazinone derivative having remarkable anti-inflammatory, anti-tuberculous and antivirus actions represented by the general formula:
WHEREIN R1 represents a lower alkyl group of from 1-4 carbon atoms, a lower alkoxyl group of from 1-4 carbon atoms, or a lower alkylthio group of from 1-4 carbon atoms; R2 represents a hydrogen or a methyl group; and X represents a halogen atom and a lower alkoxy group which is prepared by reacting a hydrazine derivative with a Beta -benzoylpropionic acid derivative.
摘要:
The production of 2-alkylpyridazonium compounds by reaction of pyridazones-(6) with alkylating agents, and the new 2alkylpyridazonium compounds. The compounds which can be prepared by the process according to the invention are pharmaceuticals and valuable starting materials for the production of dyes, pharmaceuticals and pesticides.
摘要:
2-(WI-CHLOROALKYL)-6-ARYL OR HETEROCYCLIC SUBSTITUTED4,5-DIHYDROPYRIDAZIN(2H)-3-ONES, E.G., 2-(4-CHLOROBUTYL)6-(2-THIENYL)-4,5-DIHYDROPYRIDAZIN(2H)-3-ONES, ARE PREPARED BY CHLORINATING THE CONDENSATION PRODUCT FORMED BY CONDENSING W-HYDRAZINOALKANOLS WITH ARYL OR HETEROCYCLIC-Y-KETOBUTYRIC ACIDS AND ARE USEFUL AS INTERMEDIATES IN PREPARING ANTI-DEPRESSANTS AND ANALGESICS.
摘要:
CERTAIN 6-SUBSTITUTED A-(3-PYRIDAZON - 2 YL) ALIPHATIC ACIDS, SALTS AND IN PARTICULAR SUBSTITUTED AMIDES ARE DISCLOSED, AND PROCESSES FOR THEIR MANUFACTURE. THE SUBSTITUTED AMIDE COMPOUNDS INCLUDE THOSE HAVING VALUABLE ANTI-INFLAMMATORY ACTION IN HUMANS AND ANIMALS, ESPECIALLY WHEN THEY ARE OPTICALLY ACTIVE. (-)NMETHYL - N - (2-PHENYLISOPROPYL)2-2(6 PHENYL-3-PYRIDAZONYL) ACETAMIDE IS PARTICULARLY MENTIONED.
摘要:
A SERIES OF SUBSTITUTED PYRIDAZINES AND 1,2,4-TRIAZINES HAVING ANTI-INFLAMMATORY ACTIVITY IS DESCRIBED. THESE COMPOUNDS ARE PREPARED FROM 3,6-DISTRIBUTED-S-TETRAZINES BY TREATMENT WITH A CYCLIC ENOL ETHER, AN ACETYLENIC AMINI, AN ACETYLENIC ETHER, A CYCLIC ENOL ESTER, OR AN IMINO ETHER.