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公开(公告)号：US5130122A
公开(公告)日：1992-07-14
申请号：US581025
申请日：1990-09-12
申请人： Esmail Tabibi , Arthur A. Siciliano
发明人： Esmail Tabibi , Arthur A. Siciliano
CPC分类号： A61K8/06 , A61K8/39 , A61K8/4926 , A61K8/922 , A61K9/1075 , A61Q11/00 , A61K2800/21 , Y10S514/90 , Y10S514/901 , Y10S514/902 , Y10S514/938 , Y10S514/943
摘要： Oral cavity and dental products are prepared by microemulsifying an adsorptive oil in an aqueous medium to produce uniform submicron sized droplets. The products avoid the generally unaesthetic, oily, and unpleasant taste problems of previous similar products.
摘要翻译： 通过在水性介质中微乳化吸附油以制备均匀的亚微米尺寸的液滴来制备口腔和牙科产品。 这些产品避免了以前类似产品的一般不美观，油腻和不愉快的味道问题。
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62.发明授权Anti-plaque compositions comprising a combination of morpholinoamino alcohol and metal salts 失效抗斑块组合物包含吗啉代氨基醇和金属盐的组合
公开(公告)号：US5085850A
公开(公告)日：1992-02-04
申请号：US612037
申请日：1990-11-09
IPC分类号： A23G20060101 , A61K20060101 , A61K8/19 , A61K8/27 , A61K8/49 , A61K31/04 , A61K31/535 , A61K33/06 , A61K33/24 , A61K33/30 , A61K33/34 , A61Q11/00 , C07D295/03
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/27 , A61K8/49 , Y10S514/901
摘要： Compositions having improved anti-plaque and anti-gingivitis activity comprise a synergistic combination of a) a morpholinoamino alcohol or salt thereof, such as 3-(4- propylheptyl)-4-(2-hydroxyethyl) morpholine, and b) a metal salt, such as the salts of divalent zinc, copper and magnesium.
摘要翻译： 具有改善的抗斑块和抗牙龈炎活性的组合物包括a）吗啉代氨基醇或其盐如3-（4-丙基庚基）-4-（2-羟乙基）吗啉和b）金属盐的协同组合 ，例如二价锌，铜和镁的盐。
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公开(公告)号：US5071977A
公开(公告)日：1991-12-10
申请号：US349772
申请日：1989-05-10
申请人： Frederick J. Cassels , Jack London
发明人： Frederick J. Cassels , Jack London
CPC分类号： C12P19/04 , A61K8/60 , A61Q11/00 , Y10S435/885 , Y10S514/901
摘要： A purified oligosaccharide consisting of a hexasaccharide with a native molecular weight of 959 which can be isolated from the cell walls of Streptococcus sanguis. The oligosaccharide is able to significantly block the interaction between the human oral plaque bacteria Streptococcus sanguis H1 and Capnocytophaga ochracea ATCC 33596. This purified oligosaccharide contains saccharide components found to inhibit many known interactions between plaque bacteria and may be effective in prevention, inhibition and reversal of dental plaque deposits. The oligosaccharide may be applied effectively when incorporated in toothpastes, mouth wash, etc.
摘要翻译： 由天然分子量为959的六糖组成的纯化寡糖，其可从链球菌的细胞壁分离。 该寡糖能够显着阻断人类口腔菌血清型链球菌H1和卡尼氏囊杆菌ATCC 33596之间的相互作用。该纯化的寡糖含有发现抑制斑块细菌之间许多已知相互作用的糖成分，并且可能有效预防，抑制和逆转 牙菌斑沉积物 当掺入牙膏，漱口剂等时，可以有效地应用寡糖。
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64.发明授权Method of treating the oral cavity with oral hygiene preparations containing active SnF.sub.2 失效用含有活性SnF2的口腔卫生制剂治疗口腔的方法
公开(公告)号：US5057308A
公开(公告)日：1991-10-15
申请号：US535913
申请日：1990-06-08
申请人： Ira D. Hill , Robert D. White
发明人： Ira D. Hill , Robert D. White
IPC分类号： A61K8/04 , A61K8/21 , A61K8/44 , A61K8/46 , A61K8/73 , A61K8/86 , A61K8/894 , A61K8/898 , A61K8/90 , A61Q11/00
CPC分类号： A61K8/894 , A61K8/046 , A61K8/21 , A61K8/442 , A61K8/463 , A61K8/731 , A61K8/86 , A61K8/90 , A61Q11/00 , Y10S514/835 , Y10S514/90 , Y10S514/901 , Y10S514/902 , Y10S514/944
摘要： This invention relates to a method of treating the oral cavity with ingestible, non-foaming, non aqueous, liquid and semi-solid oral hygiene preparations containing: a nonionic surfactant, a coating substance insoluble in said surfactant and a microbially active form of stannous fluoride.
摘要翻译： 本发明涉及一种用可摄入，非发泡，非水性，液体和半固体口腔卫生制剂治疗口腔的方法，其包含：非离子表面活性剂，不溶于所述表面活性剂的包衣物质和氟化亚锡的微生物活性形式 。
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65.发明授权Inhibition of mineral deposition by phosphorylated and related polyanionic peptides 失效通过磷酸化和相关的聚阴离子肽抑制矿物沉积
公开(公告)号：US5051401A
公开(公告)日：1991-09-24
申请号：US334456
申请日：1989-04-07
申请人： C. Steven Sikes
发明人： C. Steven Sikes
CPC分类号： A61K8/88 , A61Q11/00 , C07K14/001 , A61K38/00 , Y10S514/824 , Y10S514/901
摘要： A poly-amino acid compound capable of inhibiting mineral deposition, which has the structure:poly (X).sub.m (Y).sub.nwhereeach X independently is aspartate, glutamate, glutamine, asparagine, or anionic derivatives of these amino acids, or phosphoserine,each Y independently is a phosphorylated amino acid such as phosphoserine, phosphohomoserine, phosphotyrosine, phosphothreonine, phosphoglutamine, phosphoasparagine, or mixtures of these residues,m is 2 to 150,n is 1 to 3, andn+m is .gtoreq.5, andsalts of these peptides.
摘要翻译： 能够抑制矿物质沉积的聚氨基酸化合物，其结构如下：其中X分别为天冬氨酸，谷氨酸，谷氨酰胺，天冬酰胺或这些氨基酸的阴离子衍生物或聚磷酸丝氨酸， 每个Y独立地是磷酸丝氨酸，磷酸高丝氨酸，磷酸酪氨酸，磷酸苏氨酸，磷酸谷氨酰胺，磷酸氨基马来酸或这些残基的混合物的磷酸化氨基酸，m为2至150，n为1至3，n + m为≥5， 和这些肽的盐。
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公开(公告)号：US5032388A
公开(公告)日：1991-07-16
申请号：US246287
申请日：1988-09-19
申请人： Matti H. A. Tikkanen
发明人： Matti H. A. Tikkanen
CPC分类号： A61K8/44 , A61Q11/00 , A61K2800/51 , Y10S514/899 , Y10S514/901
摘要： Tartar formation on teeth is prevented with compositions of a sodium salt ethylenediaminetetraacetic acid having a pH between about 5.5 and 9.0 in a carrier which permits application to the teeth. Aqueous solution may be used for this purpose as well as toothpaste compositions.
摘要翻译： 在允许施用于牙齿的载体中，通过具有约5.5至9.0的pH值的钠盐乙二胺四乙酸的组合物防止牙齿上的鞑靼形成。 水溶液可用于此目的以及牙膏组合物。
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公开(公告)号：US5028415A
公开(公告)日：1991-07-02
申请号：US285578
申请日：1988-12-16
CPC分类号： A61Q11/00 , A61K8/365 , A61K8/8164 , Y10S514/835 , Y10S514/90 , Y10S514/901 , Y10S514/902
摘要： The present invention relates to oral compositions, such as dentifrices, toothpastes and mouthwashes, which provide an anticalculus benefit. These compositions comprise a safe and effective amount of an anticalculus agent which is a polyepoxysuccinic acid, or its pharmaceutically-acceptable salts, along with a pharmaceutically-acceptable carrier. The present invention also relates to a method for inhibiting or reducing the development of dental calculus by contacting the oral cavity with a safe and effective amount of an anticalculus agent which is a polyepoxysuccinic acid, or its pharmaceutically-acceptable salt.
摘要翻译： 本发明涉及提供抗牙结石益处的口腔组合物，例如洁齿剂，牙膏和漱口水。 这些组合物包含安全有效量的抗结石剂，其是聚环氧琥珀酸，或其药学上可接受的盐以及药学上可接受的载体。 本发明还涉及通过使口腔与安全有效量的抗结石剂（其是聚环氧琥珀酸）或其药学上可接受的盐接触来抑制或减少牙垢的发展的方法。
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公开(公告)号：US4980153A
公开(公告)日：1990-12-25
申请号：US324207
申请日：1989-03-15
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/347 , Y10S514/90 , Y10S514/901 , Y10S514/902
摘要： An oral hygiene composition in the form of a dentifrice or a mouthwash, comprising: (a) from 0.01 to 2% by weight of the composition of an antibacterial compound of formula (I): ##STR1## in which R.sup.1 is oxygen, sulphur or an alkylene group of from 1 to 6 carbon atoms, each of R.sub.2 to R.sub.6 and R.sup.2 ' to R.sup.6 ' is hydrogen, hydroxyl or halogen; (b) from 0 to 90% by weight of a dentally acceptable abrasive, (c) from 0.1% to 15% by weight of a dialkali or tetra-alkali metal pyrophosphate salt or a mixture thereof and (d) water.
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公开(公告)号：US4952392A
公开(公告)日：1990-08-28
申请号：US387083
申请日：1989-07-27
申请人： Neville Thame
发明人： Neville Thame
IPC分类号： A61K8/27 , A61K8/97 , A61K36/24 , A61K36/886 , A61Q11/00
CPC分类号： A61Q11/00 , A61K36/24 , A61K36/886 , A61K8/27 , A61K8/97 , Y10S514/90 , Y10S514/901 , Y10S514/902
摘要： Oral hygiene methods and compositions for reducing plaque and for the prevention and treatment of periodontal diseases of bacterial etiology by significantly reducing bacterial activity in the oral cavity through the inclusion of at least about 0.03% by weight of an extract of the perennial herb periwinkle in the compositions and applying the compositions to the oral cavity.
摘要翻译： 口腔卫生方法和用于减少斑块的预防和治疗细菌病因的牙周病的组合物，通过在至少约0.03重量％的多年生草本植物长春花提取物中包含至少约0.03重量％的显着降低口腔中的细菌活性 组合物并将组合物施用于口腔。
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公开(公告)号：US4935225A
公开(公告)日：1990-06-19
申请号：US346259
申请日：1989-05-01
CPC分类号： A61K8/44 , A61Q11/00 , Y10S514/817 , Y10S514/901 , Y10S514/91
摘要： An appetite suppressant oral composition containing Benzocaine, high impact flavor and a sweetening agent, in the form of a dental cream or a mouthspray. A novel method of reducing appetite and thereby intended for controlling weight of consumers, which comprises applying to the oral cavity a high impact flavor in a dentifrice or mouthspray.
摘要翻译： 含有苯佐卡因，高冲击风味和甜味剂的食欲抑制剂口服组合物，其形式为牙膏或口腔喷雾剂。 一种降低食欲并因此旨在控制消费者重量的新方法，其包括向洁口剂或口腔喷雾剂施用高冲击风味。
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