公开(公告)号：US20040156783A1

公开(公告)日：2004-08-12

申请号：US10685172

申请日：2003-10-14

Applicant: Mallinckrodt Inc.

Inventor： Raghavan Rajagopalan ,  Samuel I. Achilefu ,  Joseph E. Bugaj ,  Richard B. Dorshow ,  Muthunadar P. Periasamy

IPC: A61K049/00 ,  C07K014/705

CPC classification number: C09B23/083 ,  A61K41/0057 ,  A61K41/0061 ,  A61K41/0071 ,  A61K47/546 ,  A61K47/66 ,  B82Y5/00 ,  C09B47/045 ,  C09B47/30 ,  Y10S436/80 ,  Y10T436/13

Abstract: The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates via Type I and/or Type II mechanisms. Other Dye or azide components may operate by the same or different mechanisms. Selection of particular components in a compound, and formulation of the compound(s) in a composition permit different activation wavelengths to be used for different therapies. A targeting moiety may be added to the compound or composition so that the Dye locates at a particular site, such as a hormone-sensitive tumor, for diagnosis and/or treatment. The compounds and compositions may be incorporated within liposomes.

Abstract translation: 本发明公开了用于双光疗法和组合治疗和诊断肿瘤和其他病变的化合物和组合物。 化合物具有染料，当光活化时，它们通过I型和/或II型机制进行操作。 其他染料或叠氮化物组分可以通过相同或不同的机理操作。 选择化合物中的特定组分以及组合物中化合物的配制允许不同的激活波长用于不同疗法。 可以将靶向部分加入到化合物或组合物中，使得染料位于特定部位，例如激素敏感性肿瘤，用于诊断和/或治疗。 化合物和组合物可以掺入脂质体中。

公开(公告)号：US20030130252A1

公开(公告)日：2003-07-10

申请号：US10318659

申请日：2002-12-12

Applicant: Pharmacyclics, Inc.

Inventor： Richard A. Miller

IPC: A61K031/555

CPC classification number: A61K31/555 ,  A61K47/546 ,  A61K47/60

Abstract: The present invention relates to use of a compound of Formula I: 1 for improving neurologic functions in patients afflicted with systemic lung cancer that has metastasized to the brain (brain metastases).

Abstract translation: 本发明涉及式I化合物用于改善患有转移至脑的全身性肺癌（脑转移）的患者的神经功能。

公开(公告)号：US06207660B1

公开(公告)日：2001-03-27

申请号：US09325890

申请日：1999-06-04

Applicant: Jonathan L. Sessler ,  Darren Magda ,  Tarak Mody ,  Pavel Anzenbacher, Jr. ,  Joan Carvalho

Inventor： Jonathan L. Sessler ,  Darren Magda ,  Tarak Mody ,  Pavel Anzenbacher, Jr. ,  Joan Carvalho

IPC: C07D48722

CPC classification number: A61K41/0038 ,  A61K41/0033 ,  A61K41/0076 ,  A61K47/546

Abstract: Texaphyrin/chemotherapeutic drug conjugates, optionally including a platinum(II) or platinum(IV) metal chelating site and/or complex, are useful for treating atheroma, tumors and other neoplastic tissue, neovascular-related diseases, as well as other conditions that are typically responsive to chemotherapy, radiation sensitization and photodynamic therapy.

Abstract translation: 任意包括铂（II）或铂（IV）金属螯合位点和/或络合物的特拉法林/化疗药物偶联物可用于治疗动脉粥样化，肿瘤和其他肿瘤组织，新生血管相关疾病以及其它条件 通常对化学疗法，辐射敏化和光动力疗法有反应。