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公开(公告)号：US20200058385A1
公开(公告)日：2020-02-20
申请号：US16662216
申请日：2019-10-24
发明人： Koji YOKOUCHI
摘要： The drug inspection assisting apparatus includes: a drug collating unit configured to collate a reference image of each drug listed in the prescription and a collation-target image based on a captured image of drugs packaged in the packaging bag and determine whether or not the drug shown by the collation-target image and the drug shown by the reference image are the same drug; a listing-table creating unit configured to create, for each kind of the drugs to be packaged in the packaging bag, a listing table including the reference image of drug to be dispensed according to the prescription and all images which are determined to show the same drug as the drug shown by the reference image, among collation-target images; and a display control unit configured to cause a display device to display the listing table for a single kind of drug on a display screen.
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公开(公告)号：US10519117B2
公开(公告)日：2019-12-31
申请号：US16293100
申请日：2019-03-05
发明人： Tetsuro Uchida , Sayuri Uehara , Takayoshi Tsuzuki , Yusuke Okubo , Yuta Kobayashi , Yu Koseki
IPC分类号： C07D241/24
摘要： The purpose of the present invention is to provide a method for producing 6-bromo-3-hydroxy-2-pyrazinecarboxamide in which the content ratio of impurities is reduced. This production method includes a step of obtaining 6-bromo-3-hydroxy-2-pyrazinecarboxamide crystal having diffraction angles expressed in degrees 2θ of 5.5, 20.1, 23.7, 26.7, 27.5, and 28.1° and/or diffraction angles expressed in degrees 2θ of 7.1, 21.4, 25.2, 25.7, 27.1, and 28.8° in powder X-ray diffraction.
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公开(公告)号：US20190175736A1
公开(公告)日：2019-06-13
申请号：US16321973
申请日：2017-08-21
发明人： Yuichi FUNASE , Masahiro KUROKAWA
摘要： Provided is a composition containing a buffer to be used at the time of labeling of a chelated targeting agent with 90Y, 153Sm, 165Dy, 165Er, 166Ho, or 177Lu. At least one kind of buffer selected from the group consisting of benzoic acid, maleic acid, fumaric acid, succinic acid, and salts thereof is incorporated in a composition containing a chelated targeting agent.
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公开(公告)号：US20190145688A1
公开(公告)日：2019-05-16
申请号：US16300240
申请日：2017-03-15
发明人： Katsuhiro Tsuno
摘要： The present invention provides a transport container comprising; a first container having a first inner wall with a storage space for storing a transported object and a first outer wall provided on the outside of the first inner wall so as to form, with the first inner wall, a vacuum space therebetween; a first lid that is heat-insulating and is for removably sealing a first opening of the first container; a second container having a second inner wall with a space for storing the first container and the first lid and a second outer wall provided on the outside of the second inner wall so as to form, with the second inner wall, a vacuum space therebetween; a second lid that is heat-insulating and is for removably sealing a second opening of the second container; and a heat storage material for surrounding the transported object inside the storage space.
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公开(公告)号：US20190119242A1
公开(公告)日：2019-04-25
申请号：US16089633
申请日：2017-03-30
发明人： Kentaro ISHIHARA , Tsuyoshi ARAI
IPC分类号： C07D333/54 , B01J19/12
摘要： Provided is a method for industrially producing 5-(bromomethyl)-1-benzothiophene. The production method according to the present invention comprises: (1) a step for introducing 5-methyl-1-benzothiophene, a brominating agent, and a solvent into a reactor; (2) a step for emitting light having a wavelength range of 200-780 nm inside the reactor; and (3) a step for recovering 5-(bromomethyl)-1-benzothiophene from the reactor.
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公开(公告)号：US10238632B2
公开(公告)日：2019-03-26
申请号：US15735022
申请日：2016-06-10
发明人： Takeaki Yano
IPC分类号： A61K31/397
摘要： A sigma receptor-binding agent, which comprises an alkyl ether derivative represented by formula [1] or a salt thereof is provided. wherein R1 and R2, which are the same or different, each represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted aryl group, or the like; R3 represents an optionally protected hydroxyl group or the like; m and n, which are the same or different, each represent an integer of 1 to 6.
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公开(公告)号：US20240041866A1
公开(公告)日：2024-02-08
申请号：US18256153
申请日：2021-12-09
发明人： Kosuke KAKITA
IPC分类号： A61K31/4965 , A61K47/18 , A61K47/22 , A61K47/02 , A61K47/20
CPC分类号： A61K31/4965 , A61K47/183 , A61K47/22 , A61K47/02 , A61K47/20
摘要： A pharmaceutical composition comprising Components (1) and (2):
(1) 6-fluoro-3-hydroxy-2-pyrazinecarboxamide or a salt thereof; and
(2) a compound having a partial structure containing two heteroatoms separated by at least two carbon atoms, or a sulfite thereof.-
公开(公告)号：US20230346745A1
公开(公告)日：2023-11-02
申请号：US18220218
申请日：2023-07-10
IPC分类号： A61K31/397 , A61P25/28
CPC分类号： A61K31/397 , A61P25/28
摘要： Provided are a drug and a method which suppress progress of tauopathy such as Alzheimer's disease. 1-(3-(2-(1-B enzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of reducing the amount of phosphorylated tau protein and an effect of reducing the amount of amyloid β protein in the brain parenchyma, and thus is effective as an agent for preventing or treating tauopathy. Tauopathy can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.
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69.发明公开公开(公告)号：US20230201238A1
公开(公告)日：2023-06-29
申请号：US17927589
申请日：2021-05-26
发明人： Takashi KOMENO , Nozomi YAMASHITA , Chie KUROSAKI
IPC分类号： A61K31/7076 , A61K31/4965 , A61P31/16
CPC分类号： A61K31/7076 , A61K31/4965 , A61P31/16
摘要： The present invention addresses the problem of providing a therapeutic agent for RNA viral infection that includes a novel combination of a pyrazine derivative and a specific compound, the novel combination exhibiting an effect against the RNA virus. The present invention also addresses the problem of providing a therapeutic agent for RNA viral infection that includes a combination of a pyrazine derivative and a specific compound, the combination being capable of simultaneously enhancing anti-virus activities against multiple RNA viruses. The present invention provides a therapeutic agent for RNA viral infection obtained by combining a pyrazine derivative or a salt thereof and a thiopurine derivative.
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公开(公告)号：US11679083B2
公开(公告)日：2023-06-20
申请号：US16958469
申请日：2018-12-14
发明人： Makoto Ono , Takafumi Hirota , Iori Mizogaki
IPC分类号： A61K9/19 , A61K9/00 , A61K31/4965
CPC分类号： A61K9/19 , A61K9/0019 , A61K31/4965
摘要： This method for producing a freeze-dried formulation including an amorphous form of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide sodium salt is useful as a method for producing a freeze-dried formulation having uniform quality.
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