公开(公告)号：US11548878B2

公开(公告)日：2023-01-10

申请号：US16760512

申请日：2018-10-30

申请人： FUJIFILM Toyama Chemical Co., Ltd.

发明人： Takeaki Yano ,  Kaori Miyamoto ,  Koichi Saito

IPC分类号： C07D409/12 ,  A61K31/397

摘要： Required are: a compound having high affinity for an emopamil binding protein; and a method for activating or inhibiting the emopamil binding protein, using such a compound. According to the present invention, provided is an emopamil binding protein binding agent comprising an alkyl ether derivative represented by the following formula [1] or a salt thereof: wherein R1 and R2, which are the same or different, each represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted aryl group, etc.; R3 represents an optionally protected hydroxyl group, etc.; and m and n, which are the same or different, each represent an integer of 1 to 6.

公开(公告)号：US11479547B2

公开(公告)日：2022-10-25

申请号：US16760512

申请日：2018-10-30

申请人： FUJIFILM Toyama Chemical Co., Ltd.

发明人： Takeaki Yano ,  Kaori Miyamoto ,  Koichi Saito

IPC分类号： C07D409/12 ,  A61K31/397

摘要： Required are: a compound having high affinity for an emopamil binding protein; and a method for activating or inhibiting the emopamil binding protein, using such a compound. According to the present invention, provided is an emopamil binding protein binding agent comprising an alkyl ether derivative represented by the following formula [1] or a salt thereof: wherein R1 and R2, which are the same or different, each represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted aryl group, etc.; R3 represents an optionally protected hydroxyl group, etc.; and m and n, which are the same or different, each represent an integer of 1 to 6.

公开(公告)号：US10238632B2

公开(公告)日：2019-03-26

申请号：US15735022

申请日：2016-06-10

申请人： FUJIFILM Toyama Chemical Co., Ltd.

发明人： Takeaki Yano

IPC分类号： A61K31/397

摘要： A sigma receptor-binding agent, which comprises an alkyl ether derivative represented by formula [1] or a salt thereof is provided. wherein R1 and R2, which are the same or different, each represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted aryl group, or the like; R3 represents an optionally protected hydroxyl group or the like; m and n, which are the same or different, each represent an integer of 1 to 6.