公开(公告)号：US20190194146A1

公开(公告)日：2019-06-27

申请号：US16293100

申请日：2019-03-05

申请人： FUJIFILM Toyama Chemical Co., Ltd.

发明人： Tetsuro UCHIDA ,  Sayuri Uehara ,  Takayoshi Tsuzuki ,  Yusuke Okubo ,  Yuta Kobayashi ,  Yu Koseki

IPC分类号： C07D241/24

CPC分类号： C07D241/24

摘要： The purpose of the present invention is to provide a method for producing 6-bromo-3-hydroxy-2-pyrazinecarboxamide in which the content ratio of impurities is reduced. This production method includes a step of obtaining 6-bromo-3-hydroxy-2-pyrazinecarboxamide crystal having diffraction angles expressed in degrees 2θ of 5.5, 20.1, 23.7, 26.7, 27.5, and 28.1° and/or diffraction angles expressed in degrees 2θ of 7.1, 21.4, 25.2, 25.7, 27.1, and 28.8° in powder X-ray diffraction.

公开(公告)号：US10519117B2

公开(公告)日：2019-12-31

申请号：US16293100

申请日：2019-03-05

申请人： FUJIFILM Toyama Chemical Co., Ltd.

发明人： Tetsuro Uchida ,  Sayuri Uehara ,  Takayoshi Tsuzuki ,  Yusuke Okubo ,  Yuta Kobayashi ,  Yu Koseki

IPC分类号： C07D241/24

摘要： The purpose of the present invention is to provide a method for producing 6-bromo-3-hydroxy-2-pyrazinecarboxamide in which the content ratio of impurities is reduced. This production method includes a step of obtaining 6-bromo-3-hydroxy-2-pyrazinecarboxamide crystal having diffraction angles expressed in degrees 2θ of 5.5, 20.1, 23.7, 26.7, 27.5, and 28.1° and/or diffraction angles expressed in degrees 2θ of 7.1, 21.4, 25.2, 25.7, 27.1, and 28.8° in powder X-ray diffraction.

公开(公告)号：US10266501B2

公开(公告)日：2019-04-23

申请号：US15580731

申请日：2016-06-08

申请人： FUJIFILM Toyama Chemical Co., Ltd.

发明人： Tetsuro Uchida ,  Sayuri Uehara ,  Takayoshi Tsuzuki ,  Yusuke Okubo ,  Yuta Kobayashi ,  Yu Koseki

IPC分类号： C07D241/24

摘要： The purpose of the present invention is to provide a method for producing 6-bromo-3-hydroxy-2-pyrazinecarboxamide in which the content ratio of impurities is reduced. This production method includes a step of obtaining 6-bromo-3-hydroxy-2-pyrazinecarboxamide crystal having diffraction angles expressed in degrees 2θ of 5.5, 20.1, 23.7, 26.7, 27.5, and 28.1° and/or diffraction angles expressed in degrees 2θ of 7.1, 21.4, 25.2, 25.7, 27.1, and 28.8° in powder X-ray diffraction.