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61.发明公开公开(公告)号：US20240142528A1
公开(公告)日：2024-05-02
申请号：US18539619
申请日：2023-12-14
Applicant: California Institute of Technology
Inventor： Farshid ROUMI , Jamshid ROUMI
IPC: G01R31/385 , G01R31/382 , G01R31/64 , H01M10/42 , H01M10/48
CPC classification number: G01R31/385 , G01R31/382 , G01R31/64 , H01M10/4257 , H01M10/48 , G01R31/392
Abstract: A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.
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公开(公告)号：US20240141326A1
公开(公告)日：2024-05-02
申请号：US18278586
申请日：2022-02-24
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Daniel DAR , Dianne K. NEWMAN , Kirsten FRIEDA , Long CAI
IPC: C12N15/10
CPC classification number: C12N15/1065 , C12N15/1055 , C12N15/1058
Abstract: Method for detecting and barcoding the molecular changes occurring in two or more samples upon exposure to different stimuli. This disclosure herein sets for methods that allow a targeted transcriptome-imaging approach that records both gene-expression and spatial context within microscale assemblies at a single-cell and molecule resolution on biological samples. This disclosure herein sets for methods that allows the application to a variety of biological samples for the study of cellular processes, growth, and interactions between biological samples.
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公开(公告)号：US11965172B2
公开(公告)日：2024-04-23
申请号：US16673823
申请日：2019-11-04
Applicant: California Institute of Technology
Inventor： Bruce A. Hay , Georg Oberhofer , Tobin William Ivy
CPC classification number: C12N15/85 , C12N9/22 , C12N15/907 , C12N2310/20 , C12N2800/40 , C12N2800/50 , C12N2810/10
Abstract: Described herein are embodiments relating to manipulation of populations and sex ratio in populations through DNA sequence modifications.
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公开(公告)号：US20240125783A1
公开(公告)日：2024-04-18
申请号：US18491255
申请日：2023-10-20
Applicant: California Institute of Technology
Inventor： Mitchell Guttman , Mario R. Blanco , Ward Walkup, IV
IPC: G01N33/573 , C12N15/90
CPC classification number: G01N33/573 , C12N15/907 , C12Y201/01043
Abstract: In some embodiments, methods of detecting an association between a query protein and a target moiety are described. In some embodiments, compositions are described. In some embodiments, kits are described.
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公开(公告)号：US20240125649A1
公开(公告)日：2024-04-18
申请号：US18365821
申请日：2023-08-04
Applicant: California Institute of Technology
Inventor： Seyedeh Sona Hosseini
CPC classification number: G01J3/0256 , G01J3/0202 , G01J3/0208 , G01J3/0272 , G01J3/0291 , G01J3/443
Abstract: Ultra-miniature spatial heterodyne spectrometers (SHSs) are presented. Ultra-miniature SHSs in accordance with the invention, comprise a beam-splitter and gratings configured to generate a fringe pattern for spectroscopic detection. Many embodiments include input optics and a sensor and are configured in a way to omit collimating optics and imaging optics from the SHS. Compared to conventional SHSs known in the art, the present invention enables fewer parts, significantly smaller and lighter SHSs, are more efficient and robust, and require less maintenance. Many embodiments are field-deployable, in that such embodiments can be deployed for hand held use in real-world or remote activities outside of research or diagnostic facilities.
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Patent Agency Ranking
公开(公告)号：US11944848B2
公开(公告)日：2024-04-02
申请号：US17816373
申请日：2022-07-29
Applicant: California Institute of Technology
Inventor： Avinoam D. Bar-Zion , Atousa Nourmahnad , David Maresca , Mikhail Shapiro
IPC: A61N7/00
CPC classification number: A61N7/00 , A61N2007/0004 , A61N2007/0039 , A61N2007/0052 , A61N2007/0082
Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
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公开(公告)号：US20240101957A1
公开(公告)日：2024-03-28
申请号：US18460022
申请日：2023-09-01
Inventor： Magdalena Zernicka-Goetz , Bailey A.T. Weatherbee , Carlos W. Gantner
CPC classification number: C12N5/0604 , C12M23/12 , C12N5/0031 , G01N33/5044 , C12N2501/60 , C12N2502/02
Abstract: Disclosed herein include methods, compositions and culture media for generating synthetic embryos in vitro from mammalian pluripotent stem cells such as pluripotent embryonic stem cells. In some embodiments, the method can comprise co-culturing a wild-type mammalian pluripotent stem cell and modified mammalian pluripotent stem cells comprising one or more genes encoding transcription factors that can drive generation of extraembryonic cells or extraembryonic-like cells (e.g., GATA6 gene, SOX17 gene, GATA3 gene and/or TFAP2C gene) under a condition in a culture medium allowing the pluripotent stem cells to self-organize into a post-implantation embryo structure. In some embodiments, the pluripotent embryonic stem cells are human pluripotent embryonic stem cells and the generated synthetic embryo is a human embryo.
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公开(公告)号：US20240101606A1
公开(公告)日：2024-03-28
申请号：US18316102
申请日：2023-05-11
Applicant: California Institute of Technology
Inventor： Lucy S. Chong , Ronghui Zhu , Xiaofei Ge , Michael B. Elowitz , Mark W. Budde
CPC classification number: C07K14/001 , C12N9/22
Abstract: Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.
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69.发明公开公开(公告)号：US20240084360A1
公开(公告)日：2024-03-14
申请号：US18351461
申请日：2023-07-12
Applicant: California Institute of Technology
Inventor： Rustem F. Ismagilov , Natalie Wu-Woods , Jacob T. Barlow , Anna E. Romano
IPC: C12Q1/6806
CPC classification number: C12Q1/6806
Abstract: Provided herein are methods and systems to selectively deplete a biological sample of host compartments and/or host nucleic acid while enriching the sample microbial compartments and/or related microbial nucleic acid. In addition, provided herein are compositions, methods and systems related to said host depletion and microbial enrichment methods and systems.
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公开(公告)号：US11921141B2
公开(公告)日：2024-03-05
申请号：US17191443
申请日：2021-03-03
Applicant: California Institute of Technology
Inventor： Raj M. Katti , Harpreet Singh Arora , Keith C. Schwab , Michael L Roukes , Stevan Nadj-Perge
IPC: H01L31/112 , G01R29/08 , G01R31/28 , H01L31/02 , H01L31/101 , H10N60/12
CPC classification number: G01R29/0878 , G01R31/2824 , H01L31/02019 , H01L31/1013 , H01L31/112 , H10N60/12
Abstract: A graphene-based broadband radiation sensor and methods for operation thereof are disclosed. The radiation sensor includes an electrical signal path for carrying electrical signals and one or more resonance structures connected to the electrical signal path. Each resonance structure includes a resonator having a resonant frequency. Each resonance structure also includes a graphene junction connected in series with the resonator, the graphene junction including a graphene layer and having an impedance that is dependent on a temperature of the graphene layer. Each resonance structure further includes a heating element that is thermally coupled to the graphene layer and is configured to receive an incident photon, where the temperature of the graphene layer increases in response to the heating element receiving the incident photon.
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