公开(公告)号：US20030190720A1

公开(公告)日：2003-10-09

申请号：US10121058

申请日：2002-04-12

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC: C12P021/02 ,  C12N005/06 ,  C07H021/04 ,  C12N009/00

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030190718A1

公开(公告)日：2003-10-09

申请号：US10121055

申请日：2002-04-12

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC: C12P021/02 ,  C12N005/06 ,  C07H021/04 ,  C12N009/00

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030190610A1

公开(公告)日：2003-10-09

申请号：US09906618

申请日：2001-07-16

Applicant: Genentech, Inc.

Inventor： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC: C12Q001/68 ,  G01N033/53 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435

CPC classification number: C07K14/47 ,  G01N33/68 ,  G01N2333/485

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030187218A1

公开(公告)日：2003-10-02

申请号：US10232228

申请日：2002-08-29

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Luc Desnoyers ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Victoria Smith ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07H021/04 ,  C12N009/00

CPC classification number: C07K14/47 ,  C07K14/705

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030187217A1

公开(公告)日：2003-10-02

申请号：US10230437

申请日：2002-08-28

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Luc Desnoyers ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Victoria Smith ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07H021/04 ,  C12N009/00

CPC classification number: C07K14/705 ,  C07K14/47 ,  G01N33/574

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030187216A1

公开(公告)日：2003-10-02

申请号：US10219533

申请日：2002-08-14

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Luc Desnoyers ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Victoria Smith ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07H021/04 ,  C12N009/00

CPC classification number: C07K14/705 ,  C07K14/47 ,  G01N33/574

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030187197A1

公开(公告)日：2003-10-02

申请号：US10063647

申请日：2002-05-07

Applicant: Genentech, Inc.

Inventor： Dan L. Eaton ,  Ellen Filvaroff ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Colin K. Watanabe ,  William I. Wood

IPC: C07K014/435 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/82 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/40 ,  C07K2319/30 ,  C12N5/06 ,  Y10S530/866

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030187191A1

公开(公告)日：2003-10-02

申请号：US10012754

申请日：2001-12-07

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napolene Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC: G01N033/53 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435 ,  C07K016/40 ,  A61K038/17

CPC classification number: C07K14/47 ,  C07K14/575 ,  C07K2319/30 ,  C07K2319/40

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030186866A1

公开(公告)日：2003-10-02

申请号：US10223081

申请日：2002-08-16

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

IPC: A61K038/17 ,  C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07H021/04 ,  C12N009/00

CPC classification number: A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  Y02A50/473

Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030186407A1

公开(公告)日：2003-10-02

申请号：US10063684

申请日：2002-05-08

Applicant: Genentech, Inc.

Inventor： Dan L. Eaton ,  Ellen Filvaroff ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Colin K. Watanabe ,  William I. Wood

IPC: C12N009/00 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.