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    Compounds for intracellular delivery of therapeutic moieties to nerve cells
    61.
    发明授权
    Compounds for intracellular delivery of therapeutic moieties to nerve cells 有权
    将治疗性部分细胞内递送给神经细胞的化合物

    公开(公告)号：US07678378B2

    公开(公告)日：2010-03-16

    申请号：US10652723

    申请日：2003-08-28

    Applicant: Robert R. Webb ,  Constance A. McKee

    Inventor： Robert R. Webb ,  Constance A. McKee

    IPC: A61K38/18 ,  A61K39/385

    CPC classification number: A61K47/6807 ,  A61K47/6425 ,  Y10T436/21

    Abstract: A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM.

    Abstract translation: 用于将非细胞毒性治疗部分递送到神经细胞中的化合物，具有以下通式的化合物：BL-TM，其中：B是能够选择性结合神经细胞表面受体并通过神经介导化合物的吸收的结合剂 细胞; TM是当被神经细胞吸收时具有非细胞毒性治疗作用的治疗部分; L是连接B到TM的接头。

    Air-launchable aircraft and method of use
    62.
    发明授权
    Air-launchable aircraft and method of use 有权
    空中发射飞机及使用方法

    公开(公告)号：US07338010B2

    公开(公告)日：2008-03-04

    申请号：US10951041

    申请日：2004-09-23

    Applicant: David A. Corder ,  Jeffrey H. Koessler ,  George R. Webb

    Inventor： David A. Corder ,  Jeffrey H. Koessler ,  George R. Webb

    IPC: B64C3/56

    CPC classification number: B64C3/56 ,  B64C39/024 ,  B64C2201/021 ,  B64C2201/042 ,  B64C2201/082 ,  B64C2201/102 ,  B64C2201/123 ,  B64C2201/127 ,  B64C2201/141 ,  B64C2201/145 ,  B64C2201/165 ,  B64C2201/201

    Abstract: An air-launched aircraft includes deployable wings, elevons, and vertical fins that deploy from a fuselage during flight. The aircraft may include a control system for operating the elevons, a communication system, and batteries for powering the systems. In addition, the aircraft may include a payload module that mates with an interface in the fuselage. The payload module may include any of a variety of payloads, including cameras, sensors, and/or radar emitters. The aircraft may be powered or unpowered, and may be very small, for example, less than on the order of 10 kg (22 pounds). The aircraft may be employed at a low cost for any of a wide variety of functions, such as surveillance, or as a decoy. The deployable surfaces of the aircraft may be configured to deploy in a pre-determined order, allowing the aircraft automatically to enter controlled flight after being launched in a tumbling mode.

    Abstract translation: 一架空中飞机包括在飞行期间从机身部署的可部署的机翼，电梯和垂直翼片。 飞机可以包括用于操作电梯的控制系统，通信系统和用于为系统供电的电池。 此外，飞机可以包括与机身中的接口相配合的有效载荷模块。 有效载荷模块可以包括各种有效载荷中的任何一种，包括相机，传感器和/或雷达发射器。 该飞机可能是动力或无动力的，并且可能非常小，例如小于10kg（22磅）的量级。 飞机可以以低成本从事各种功能，例如监视或作为诱饵。 飞机的可展开的表面可以被配置成以预定的顺序部署，允许飞机在以翻滚模式发射之后自动进入受控飞行。

    Ribbed CVC structures and methods of producing
    63.
    发明申请
    Ribbed CVC structures and methods of producing 审中-公开
    罗纹CVC结构和生产方法

    公开(公告)号：US20070207268A1

    公开(公告)日：2007-09-06

    申请号：US11249860

    申请日：2005-10-12

    Applicant: R. Webb ,  Ronald Chand ,  Clifford Tanaka ,  Colby Foss

    Inventor： R. Webb ,  Ronald Chand ,  Clifford Tanaka ,  Colby Foss

    IPC: C23C16/26 ,  C23C16/00

    CPC classification number: C23C16/325 ,  C04B35/565 ,  C04B2235/6028 ,  C04B2235/94 ,  C04B2235/9653 ,  C23C16/56 ,  Y02T50/67

    Abstract: A process for making a ribbed light weight composite mirror unit. Preferred embodiments are silicon carbide composite structures. Preferred structures comprise a front smooth silicon carbide surface supported by a silicon carbide ribbed back support. The ribbed back support may be produce by milling out portions of SiC block or by the joining of multiple simple shapes to form the ribbed support. At least the smooth front SiC surface is produced using a chemical vapor composite process as described in the Background Section. These include very large mirrors that resist gravitational sagging and smaller scanning and stepping mirrors that can be pointed quickly and accurately with minimal hysteresis. Preferred milling techniques include precision water jet milling. Special bonding techniques are described to produce ribbed support from multiple parts.

    Abstract translation: 制造带肋轻质复合镜单元的方法。 优选的实施方案是碳化硅复合结构。 优选的结构包括由碳化硅肋背支撑支撑的前平滑碳化硅表面。 肋背支撑件可以通过铣削SiC块的部分或通过多个简单形状的连接来形成肋状支撑件来产生。 使用如背景技术部分中所述的化学气相复合方法，至少形成光滑的前表面SiC表面。 这些包括非常大的反射镜抵抗重力下垂和较小的扫描和步进镜，可以快速准确地以最小的滞后指向。 优选的铣削技术包括精密喷水铣削。 描述了特殊粘合技术以从多个部分产生肋状支撑。

    Missile protection system for vehicles
    64.
    发明申请
    Missile protection system for vehicles 审中-公开
    车辆导弹保护系统

    公开(公告)号：US20060283317A1

    公开(公告)日：2006-12-21

    申请号：US11184509

    申请日：2005-07-18

    Applicant: Stephan Melnychuk ,  Howard Hyman ,  David Sandler ,  R. Webb

    Inventor： Stephan Melnychuk ,  Howard Hyman ,  David Sandler ,  R. Webb

    IPC: B64D1/04 ,  F41G3/08 ,  F41G3/12

    CPC classification number: F41G3/147 ,  G01S3/7864 ,  G01S17/023 ,  G01S17/66

    Abstract: A projectile tracking system for acquiring and precisely tracking a projectile in flight in order to reveal the source from which the projectile was fired. The source is revealed by the back projection of a 3-dimensional track file. In preferred embodiments the system is installed on a vehicle, such as an un-manned blimp or other aircraft, road vehicle or ship, for locating and destroying small arms fire directed at the vehicle. A kill system may also be included on the vehicle to destroy the source of the projectile.

    Abstract translation: 一种用于在飞行中获取和精确跟踪射弹的射弹跟踪系统，以揭示射弹被射击的根源。 来源通过三维轨道文件的背投显示。 在优选实施例中，系统安装在诸如无人值班飞行器或其他飞机，道路车辆或船舶的车辆上，用于定位和销毁针对车辆的小武器。 车辆上也可能包括一个杀死系统，以摧毁射弹的来源。

    Plating uniformity control by contact ring shaping
    65.
    发明授权
    Plating uniformity control by contact ring shaping 失效
    通过接触环成形进行电镀均匀性控制

    公开(公告)号：US07025862B2

    公开(公告)日：2006-04-11

    申请号：US10278527

    申请日：2002-10-22

    Applicant: Harald Herchen ,  Henan Hao ,  Celina M. Esteban ,  Timothy R. Webb ,  Son N. Trinh

    Inventor： Harald Herchen ,  Henan Hao ,  Celina M. Esteban ,  Timothy R. Webb ,  Son N. Trinh

    IPC: C25B9/00

    CPC classification number: C25D17/06 ,  C25D7/123 ,  C25D17/001 ,  H01L21/2885 ,  Y10T29/49117 ,  Y10T29/49204 ,  Y10T29/5313 ,  Y10T29/532

    Abstract: An apparatus for providing an electrical bias to a substrate in a processing system is described. The apparatus generally includes a conductive annular body defining a central opening. The conductive annular body may have a substrate seating surface adapted to receive the substrate and a plurality of scallops formed on a surface opposing the substrate seating surface. A plurality of electrical contacts may be formed on the substrate seating surface opposite the plurality of scallops. The electrical contacts may be adapted to engage a plating surface of the substrate.

    Abstract translation: 描述了一种用于在处理系统中向基板提供电偏压的装置。 该装置通常包括限定中心开口的导电环形体。 导电环形体可以具有适于容纳衬底的衬底安置表面和形成在与衬底安置表面相对的表面上的多个扇贝。 多个电触头可以形成在与多个扇贝相对的基板支座表面上。 电触点可以适于接合基板的电镀表面。

    Compounds for intracellular delivery of therapeutic moieties to nerve cells
    66.
    发明授权
    Compounds for intracellular delivery of therapeutic moieties to nerve cells 有权
    将治疗性部分细胞内递送给神经细胞的化合物

    公开(公告)号：US06887861B1

    公开(公告)日：2005-05-03

    申请号：US09707730

    申请日：2000-11-06

    Applicant: Gordon Craig Hill ,  Stephen B. Kahl ,  Robert R. Webb ,  Constance A. McKee

    Inventor： Gordon Craig Hill ,  Stephen B. Kahl ,  Robert R. Webb ,  Constance A. McKee

    IPC: A61K47/30 ,  A61K47/42 ,  A61K47/48 ,  A61P5/00 ,  A61P25/00 ,  A61P25/04 ,  A61P31/12 ,  A81K31/56 ,  A61M36/14 ,  G01N33/00 ,  A81K31/58 ,  A81K51/00

    CPC classification number: A61K47/6807 ,  A61K47/6425 ,  Y10T436/21

    Abstract: A method for improving intracellular administration of a therapeutic agent is provided comprising: contacting cells with a compound comprising a charged derivative of a therapeutic agent having a therapeutic activity, the charged derivative being conjugated to a protein having a biological activity of being transported across a cell membrane into a cell; and having the cell transport the compound into the cell where the cell metabolizes at least a portion of the compound to form a charged metabolite product that possesses the therapeutic activity of the therapeutic agent, the charged metabolite product being less prone to being transported across the cell membrane out of the cell relative to the compound and less prone to being transported across the cell membrane out of the cell relative to the therapeutic agent.

    Abstract translation: 提供了一种用于改善细胞内施用治疗剂的方法，其包括：使细胞与包含具有治疗活性的治疗剂的带电荷的衍生物的化合物接触，所述带电荷的衍生物与具有生物活性的蛋白质缀合， 膜成细胞; 并且使细胞将化合物转运到细胞中，其中细胞代谢化合物的至少一部分以形成具有治疗剂的治疗活性的带电代谢产物，所加入的代谢产物不太容易被传输通过细胞 膜相对于化合物离开细胞，并且相对于治疗剂不太容易被传送通过细胞膜离开细胞。

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