公开(公告)号：US11460480B2

公开(公告)日：2022-10-04

申请号：US16058480

申请日：2018-08-08

申请人： Li-Cor, Inc.

发明人： George G. Burba ,  Dayle McDermitt ,  Xiaomao Lin ,  Liukang Xu ,  Dave Johnson

IPC分类号： G01P5/00 ,  G01N33/00 ,  A61B5/145 ,  G01N21/3504 ,  G01N30/86 ,  G01W1/10

摘要： Systems and methods for measuring turbulent gas flux using high-speed vertical wind speed measurements (e.g., on the order of 5-10 Hz or more frequently) and low-speed gas content measurements (e.g., on the order of 5 Hz or less frequently), without the need for the sophisticated and expensive high-speed hardware to separate gas samples (e.g., into accumulation bags) according to updrafts and downdrafts. A time series of high-speed vertical wind speed data is used as a guide to distinguish between updrafts and downdrafts. When vertical wind speed is upward (updraft), the low-speed gas content is recorded into a data structure in one location, or marked with one flag. When vertical wind speed is downward (downdraft), the low-speed gas content is recorded into a different location, or marked with a different flag. Eddy Accumulation or Relaxed Eddy Accumulation computations can be performed using the stored gas content data to determine gas flux.

公开(公告)号：US20220011265A1

公开(公告)日：2022-01-13

申请号：US17486143

申请日：2021-09-27

申请人： LI-COR, Inc.

发明人： Patrick G. Humphrey

IPC分类号： G01N27/447 ,  G06K9/32

摘要： Systems and methods for automatically identifying and characterizing one or more lanes in image data for one or more electrophoresed samples. The method includes receiving data representing an image of one or more electrophoresed samples, segmenting the data into one or multiple data segments or portions within a region of interest (ROI), wherein the one or multiple data segments represent (e.g., when visually displayed) one or multiple lane segments along a first axis in the ROI, each of the one or multiple lane segments traversing one or multiple lanes in the image data, generating an intensity profile for at least a first data segment of the one or multiple data segments along a second axis orthogonal to the first axis, and processing the intensity profile to determine a location and parameters for each of one or multiple lanes in the first data segment.

公开(公告)号：US20210293768A1

公开(公告)日：2021-09-23

申请号：US17198879

申请日：2021-03-11

申请人： Li-Cor, Inc.

发明人： Mark A. Johnson ,  Robert D. Eckles ,  Douglas J. Lynch ,  Johnathan I.E. McCoy ,  Jason Hupp

IPC分类号： G01N33/00

摘要： Gas exchange analysis methods and systems utilize a water vapor buffering component including a material configured to buffer water vapor in a flow of a gas, whereby fluctuations in the water vapor content in the flow of the gas are slowed for components downstream from the water vapor buffering component. Components downstream of the water vapor buffering component may include: a first water vapor sensor configured to receive the flow of the gas from the water vapor buffering component and configured to measure a first concentration of water vapor in the gas; a sample chamber configured to receive the gas exiting the water vapor buffering component or the first water vapor sensor and to hold a sample capable of adding or removing water vapor from the gas; and a second water vapor sensor configured to measure a second concentration of water vapor in the gas exiting the sample chamber.

公开(公告)号：US20210259553A1

公开(公告)日：2021-08-26

申请号：US17237430

申请日：2021-04-22

申请人： LI-COR, Inc.

发明人： Han-Wei Wang

IPC分类号： A61B5/00 ,  G06T11/00 ,  A61B1/04 ,  A61B1/06

摘要： Machine-readable media and computer systems are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.

公开(公告)号：US11051696B2

公开(公告)日：2021-07-06

申请号：US16359852

申请日：2019-03-20

申请人： LI-COR, Inc.

发明人： Han-Wei Wang

IPC分类号： G06T11/00 ,  A61B5/00 ,  A61B1/04 ,  A61B1/06 ,  A61B6/03 ,  A61B6/00 ,  G01N1/30

摘要： Methods are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.

公开(公告)号：US20210005290A1

公开(公告)日：2021-01-07

申请号：US16911898

申请日：2020-06-25

申请人： LI-COR, Inc.

发明人： Patrick G. Humphrey

IPC分类号： G16H10/40 ,  G06K9/32 ,  G06T7/00 ,  G16H30/40

摘要： Systems and methods for automatically identifying and characterizing one or more lanes in image data for one or more electrophoresed samples. The method includes receiving data representing an image of one or more electrophoresed samples, segmenting the data into one or multiple data segments or portions within a region of interest (ROI), wherein the one or multiple data segments represent (e.g., when visually displayed) one or multiple lane segments along a first axis in the ROI, each of the one or multiple lane segments traversing one or multiple lanes in the image data, generating an intensity profile for at least a first data segment of the one or multiple data segments along a second axis orthogonal to the first axis, and processing the intensity profile to determine a location and parameters for each of one or multiple lanes in the first data segment.

公开(公告)号：US10548991B2

公开(公告)日：2020-02-04

申请号：US14949654

申请日：2015-11-23

申请人： LI-COR, Inc.

发明人： Daniel R. Draney ,  William M. Volcheck ,  Katie Schaepe ,  Vassil Elitzin

IPC分类号： A61K49/00 ,  C09B23/10 ,  A61B5/00 ,  A61B5/20

摘要： A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

公开(公告)号：US20190338131A1

公开(公告)日：2019-11-07

申请号：US16404993

申请日：2019-05-07

申请人： LI-COR, Inc.

发明人： Silvano Sanchini ,  Rose Skopp ,  Vassil Elitzin ,  Nisha Padhye ,  Teresa Urlacher

IPC分类号： C09B23/01 ,  G01N33/58

摘要： The present disclosure embodies compounds, methods, and kits that are useful in connection with the detection of analytes of all types (e.g., biological molecules such as proteins, organic molecules, natural or synthetic molecules). The disclosure is particularly applicable to detection of proteins and nucleic acids using all types of membrane-based assays by techniques such as Western blotting, Dot blotting, Southern blotting, and Northern blotting.

公开(公告)号：US10365290B2

公开(公告)日：2019-07-30

申请号：US15491905

申请日：2017-04-19

申请人： LI-COR, Inc.

发明人： Nisha Padhye ,  Rose Skopp ,  Ying Wang

IPC分类号： C07K7/06 ,  G01N33/58 ,  G01N33/96 ,  C07K14/795 ,  C12Q1/28

摘要： Multifunctional molecular weight protein ladders and methods of making thereof are disclosed herein that are useful for determining the molecular weight of a test protein and/or the relative mass or amount of the test protein in a protein separation assay, such as gel electrophoresis or western blotting. Also included are compounds of Formula I (e.g., mono acetylated MP-11 NHS ester) that may be used to label purified proteins of the protein ladder. The MP-11 label protein ladder can be detected on a blotting membrane by exposing the microperoxidase to a suitable substrate, such as a chromogenic substrate or a chemiluminescent substrate.

公开(公告)号：US20180364101A1

公开(公告)日：2018-12-20

申请号：US16109382

申请日：2018-08-22

申请人： Li-Cor, Inc.

发明人： Serguei Koulikov

IPC分类号： G01J3/433 ,  G01N21/39 ,  G01N21/3504 ,  G01J3/36

摘要： Systems and methods for detecting trace gases utilize a resonance optical cavity and one, two or more coherent light sources coupled to the cavity through one or more cavity coupling mirrors, whereby two or more optical cavities may share the same gas volume.