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公开(公告)号：US09066694B2
公开(公告)日：2015-06-30
申请号：US11695608
申请日：2007-04-03
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Fredric C. Colman
IPC分类号： A61B5/1473 , A61B5/1486 , A61M5/172 , C12Q1/54 , A61B5/145 , H01L23/31 , H01L23/495 , G06F19/00 , A61B5/01 , A61B5/1495 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号：US08734348B2
公开(公告)日：2014-05-27
申请号：US12405987
申请日：2009-03-17
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号：US08728297B2
公开(公告)日：2014-05-20
申请号：US11279694
申请日：2006-04-13
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译： 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。
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公开(公告)号：US08660627B2
公开(公告)日：2014-02-25
申请号：US12405515
申请日：2009-03-17
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号：US08612159B2
公开(公告)日：2013-12-17
申请号：US10783675
申请日：2004-02-16
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： C23C28/00
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/14546 , A61B5/7445 , G06F19/00 , G06Q50/22 , H01L23/3107 , H01L23/49548 , H01L24/48 , H01L2224/48091 , H01L2224/48247 , H01L2924/00014 , H01L2924/01012 , H01L2924/12042 , H01L2924/14 , H01L2924/181 , H01L2924/19041 , H01L2924/3011 , Y02A90/22 , H01L2924/00 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.
摘要翻译： 分析物监测器包括传感器，传感器控制单元和显示单元。 传感器具有例如基板，形成在基板中的凹陷通道，以及设置在凹陷通道中以形成工作电极的导电材料。 传感器控制单元通常具有适于放置在皮肤上并适于接收电化学传感器的一部分的壳体。 传感器控制单元还包括设置在壳体上并被配置为耦合到传感器上的两个或更多个接触垫的两个或更多个导电触头。 发射器设置在壳体中并且耦合到多个导电接触件，用于传送使用传感器获得的数据。 显示单元具有用于接收由传感器控制单元的发送器发送的数据的接收器和耦合到接收器的显示器以显示分析物水平的指示的接收器。
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公开(公告)号：US08372005B2
公开(公告)日：2013-02-12
申请号：US12643982
申请日：2009-12-21
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号：US08357091B2
公开(公告)日：2013-01-22
申请号：US12643986
申请日：2009-12-21
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号：US08353829B2
公开(公告)日：2013-01-15
申请号：US12643975
申请日：2009-12-21
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号：US08265726B2
公开(公告)日：2012-09-11
申请号：US12614990
申请日：2009-11-09
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号：US08255031B2
公开(公告)日：2012-08-28
申请号：US12405568
申请日：2009-03-17
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
摘要翻译： 分析物监测器包括传感器，传感器控制单元和显示单元。 传感器具有例如基板，形成在基板中的凹陷通道，以及设置在凹陷通道中以形成工作电极的导电材料。 传感器控制单元通常具有适于放置在皮肤上并适于接收电化学传感器的一部分的壳体。 传感器控制单元还包括设置在壳体上并被配置为耦合到传感器上的两个或更多个接触垫的两个或更多个导电触头。 发射器设置在壳体中并且耦合到多个导电接触件，用于传送使用传感器获得的数据。 显示单元具有用于接收由传感器控制单元的发送器发送的数据的接收器和耦合到接收器的显示器以显示分析物水平的指示的接收器。 分析物监测器还可以是药物递送系统的一部分，以基于使用传感器获得的数据来改变分析物的水平。
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