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公开(公告)号：US20220281918A1
公开(公告)日：2022-09-08
申请号：US17638040
申请日：2020-08-28
Applicant: BicycleTx Limited
Inventor： Katerine VAN RIETSCHOTEN , Paul BESWICK , Mike DAWSON , Matthew BALMFORTH , Michael SKYNNER , Liuhong CHEN
Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of penicillin-binding proteins (PBPs). The invention also includes pharmaceutical compositions comprising said peptide ligands and to the use of said peptide ligands in suppressing or treating a disease or disorder mediated by bacterial infection or for providing prophylaxis to a subject at risk of infection.
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公开(公告)号：US20220227811A1
公开(公告)日：2022-07-21
申请号：US17590875
申请日：2022-02-02
Applicant: BicycleTx Limited
Inventor： Gemma MUDD , Punit UPADHYAYA , Kevin MCDONNELL , Johanna LAHDENRANTA
Abstract: The present invention relates to a heterotandem bicyclic peptide complex which comprises a first peptide ligand, which binds to EphA2, conjugated via a linker to two second peptide ligands, which bind to CD137. The invention also relates to the use of said heterotandem bicyclic peptide complex in preventing, suppressing or treating cancer.
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公开(公告)号：US20220064218A1
公开(公告)日：2022-03-03
申请号：US17422940
申请日：2020-01-15
Applicant: BicycleTx Limited
Inventor： Leonardo BALDASSARRE , Rachid LANI , Silvia PAVAN , Catherine STACE , Daniel TEUFEL
Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD38.The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and dmg conjugates in preventing, suppressing or treating a disease or disorder mediated by CD38.
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公开(公告)号：US11180531B2
公开(公告)日：2021-11-23
申请号：US16446901
申请日：2019-06-20
Applicant: BicycleTx Limited
Inventor： Paul Beswick , Liuhong Chen , Gemma Mudd , Peter Park , Katerine Van Rietschoten , Michael Rigby
Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
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公开(公告)号：US20210122804A1
公开(公告)日：2021-04-29
申请号：US17254412
申请日：2019-06-18
Applicant: BicycleTx Limited
Inventor： Daniel Teufel , Gemma MUDD , Silvia PAVAN
IPC: C07K14/705 , A61K47/64
Abstract: A peptide ligand specific for CD38 comprising a polypeptide comprising three residues selected from cysteine, L-2,3-diaminopropionic acid (Dap), N-beta-alkyl-L-2,3-diaminopropionic acid (N-AlkDap) and N-beta-haloalkyl-L-2,3-diaminopropionic acid (N-HAlk Dap), with the proviso that at least one of said three residues is selected from Dap, N-AlkDap or N-HAlkDap, the said three residues being separated by at least two loop sequences, and a molecular scaffold, the peptide being linked to the scaffold by covalent alkylamino linkages with the Dap or N-AlkDap or N-HAlkDap residues of the polypeptide and by thioether linkages with the cysteine residues of the polypeptide when the said three residues include cysteine, such that two polypeptide loops are formed on the molecular scaffold. Also provided are drug conjugates comprising the peptide ligands conjugated to one or more effector groups and pharmaceutical compositions comprising the conjugates.
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Patent Agency Ranking
公开(公告)号：US20210101932A1
公开(公告)日：2021-04-08
申请号：US17044868
申请日：2019-12-23
Applicant: BicycleTx Limited
Inventor： Liuhong CHEN , James COOKE , Kevin MCDONNELL , Gemma MUDD , Katerine VAN RIETSCHOTEN , Punit UPADHYAYA
Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of PD-L1. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by PD-L1.
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公开(公告)号：US10919937B2
公开(公告)日：2021-02-16
申请号：US16660854
申请日：2019-10-23
Applicant: BicycleTx Limited
Inventor： Paul Beswick , Gemma Elizabeth Mudd , Kevin McDonnell , Gabriela Ivanova-Berndt , Katerine Van Rietschoten , David Witty , Michael Skynner
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
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公开(公告)号：US20190389906A1
公开(公告)日：2019-12-26
申请号：US16446901
申请日：2019-06-20
Applicant: BicycleTx Limited
Inventor： Paul Beswick , Liuhong Chen , Gemma Mudd , Peter Park , Katerine Van Rietschoten , Michael Rigby
Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
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公开(公告)号：US20190263866A1
公开(公告)日：2019-08-29
申请号：US16282877
申请日：2019-02-22
Applicant: BicycleTx Limited
Inventor： Liuhong Chen , Rachid Lani , Kevin McDonnell , Gemma Elizabeth Mudd , Peter U. Park , Punit Upadhyaya
Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders and activators of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.
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公开(公告)号：US20250059236A1
公开(公告)日：2025-02-20
申请号：US18742691
申请日：2024-06-13
Applicant: BicycleTx Limited
Inventor： Liuhong Chen , Rachid Lani , Kevin McDonnell , Gemma Elizabeth Mudd , Peter Park
Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.
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