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    Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators
    51.
    发明授权
    Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators 有权
    三环茚并吡咯衍生物作为血清素受体调节剂

    公开(公告)号：US07935830B2

    公开(公告)日：2011-05-03

    申请号：US12478362

    申请日：2009-06-04

    申请人： Youssef L. Bennani ,  Bayard Huck ,  Michael J. Robarge

    发明人： Youssef L. Bennani ,  Bayard Huck ,  Michael J. Robarge

    IPC分类号： C07D209/56

    CPC分类号： C07D209/90 ,  A61K31/403 ,  C07D209/70 ,  C07D409/04 ,  C07D491/04

    摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are tricyclic indeno-pyrrole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

    摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地，本发明的化合物是三环茚并吡咯化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。

    HIGH-PURITY TEXAPHYRIN METAL COMPLEXES
    56.
    发明申请
    HIGH-PURITY TEXAPHYRIN METAL COMPLEXES 有权
    高纯度丝印金属复合物

    公开(公告)号：US20100048916A1

    公开(公告)日：2010-02-25

    申请号：US12611896

    申请日：2009-11-03

    申请人： Hugo MADDEN ,  Greg HEMMI ,  Tarak MODY

    发明人： Hugo MADDEN ,  Greg HEMMI ,  Tarak MODY

    IPC分类号： C07D209/56 ,  C07C43/20

    CPC分类号： C07F5/00 ,  A61K31/555 ,  A61K45/00 ,  C07C41/16 ,  C07C43/2055 ,  C07C205/37 ,  C07D487/22 ,  C07F5/003

    摘要： Disclosed herein are the methods and compositions for the improved synthesis of texaphyrin metal complexes. The improved synthesis results in high-purity compositions of texaphyrin metal complexes in which more than about 98% of the texaphyrin metal complexes in the composition have the same structure and/or the same molecular weight. Further described herein are pharmaceutical compositions comprising such high-purity compositions, and the use of such high-purity compositions in the treatment of cancer and cardiovascular diseases and disorders.

    摘要翻译： 本文公开了用于改进合成特沙弗林金属络合物的方法和组合物。 改进的合成导致特沙弗林金属络合物的高纯度组合物，其中组合物中超过约98％的特沙弗林金属络合物具有相同的结构和/或相同的分子量。 本文进一步描述的是包含这种高纯度组合物的药物组合物，以及这些高纯度组合物在治疗癌症和心血管疾病和病症中的用途。

    Prodrugs of CC-1065 analogs
    57.
    发明授权
    Prodrugs of CC-1065 analogs 失效
    CC-1065类似物的前药

    公开(公告)号：US07655661B2

    公开(公告)日：2010-02-02

    申请号：US12144612

    申请日：2008-06-23

    申请人： Robert Yongxin Zhao ,  Ravi V. J. Chari

    发明人： Robert Yongxin Zhao ,  Ravi V. J. Chari

    IPC分类号： A61K31/497 ,  C07D209/56

    CPC分类号： C07D307/85 ,  A61K31/407 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/675 ,  A61K47/545 ,  A61K47/548 ,  A61K47/60 ,  C07D209/42 ,  C07D209/60 ,  C07D403/14 ,  C07D405/12 ,  C07F9/5728 ,  C07F9/65583 ,  Y02A50/423 ,  Y02A50/491 ,  Y02P20/55

    摘要： Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the protecting group confers enhanced water solubility and stability upon the prodrug, and in which the prodrug also has a moiety, such as a disulfide, that can conjugate to a cell binding reagent such as an antibody. The therapeutic use of such prodrug conjugates is also described; such prodrugs of cytotoxic agents have therapeutic use because they can deliver cytotoxic prodrugs to a specific cell population for enzymatic conversion to cytotoxic drugs in a targeted fashion.

    摘要翻译： 具有可切割保护基的抗肿瘤抗生素CC-1065类似物的前药，例如哌嗪基氨基甲酸酯，4-哌啶子基 - 哌啶子基氨基甲酸酯或磷酸酯，其中保护基团赋予增强的水溶性和在前药上的稳定性， 其中前药还具有可与细胞结合试剂例如抗体缀合的部分，例如二硫化物。 还描述了这种前药缀合物的治疗用途; 这种细胞毒性药物的前药具有治疗用途，因为它们可以将细胞毒性前药递送至特定的细胞群，以靶向方式酶促转化成细胞毒性药物。

    OPTICAL RECORDING MATERIAL AND OPTICAL RECORDING MEDIA
    60.
    发明申请
    OPTICAL RECORDING MATERIAL AND OPTICAL RECORDING MEDIA 审中-公开
    光学记录材料和光学记录介质

    公开(公告)号：US20090149660A1

    公开(公告)日：2009-06-11

    申请号：US12067754

    申请日：2006-09-25

    申请人： Masahiro Shinkai ,  Atsushi Monden ,  Motohiro Inoue

    发明人： Masahiro Shinkai ,  Atsushi Monden ,  Motohiro Inoue

    IPC分类号： C07D209/56

    CPC分类号： G11B7/249 ,  C09B23/0075 ,  C09B23/06 ,  C09B45/14 ,  C09B67/0041 ,  G11B7/2467 ,  G11B7/2472 ,  G11B7/2532 ,  G11B2007/24612

    摘要： An optical recording medium provided with a recording layer that comprises a cation represented by the following general formula (1) and a chelate compound of an azo compound represented by the following general formula (2) and a metal. In the formulas, R1-R4 each independently represent a monovalent group represented by Chemical Formula (10) below or other groups, R5 and R6 each independently represent an optionally substituted alkyl group or other groups, R7 represents a hydrogen atom or other groups, Q1 and Q2 each independently represent a group that forms an optionally substituted benzene ring or other groups, at least one from among R1-R4 is a monovalent group represented by Chemical Formula (10) below, [Chemical Formula 2] [CH2═CH—CH2  (10) and at least one of Ar1 and Ar2 is an aryl or other group having a substituent capable of coordinating with a metal atom.

    摘要翻译： 一种具有记录层的光记录介质，该记录层包括由以下通式（1）表示的阳离子和由以下通式（2）表示的偶氮化合物的螯合化合物和金属。 式中，R 1 -R 4各自独立地表示由下述化学式（10）表示的一价基团或其它基团，R 5和R 6各自独立地表示任选取代的烷基或其它基团，R 7表示氢原子或其它基团，Q 1 和Q2各自独立地表示形成任选取代的苯环或其它基团的基团，R 1 -R 4中的至少一个为下述化学式（10）表示的一价基团，<β在线式描述=“In “公式”end =“lead”？> [化学式2] <？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In- 线公式“end =”lead“？> [CH2-CH-CH2（10）<？in-line-formula description =”In-line Formulas“end =”tail“？>和Ar1和Ar2中的至少一个 是具有能够与金属原子配位的取代基的芳基或其它基团。