公开(公告)号：US06194396B1

公开(公告)日：2001-02-27

申请号：US09425207

申请日：1999-10-22

申请人： Teruo Oku ,  Hiroshi Kayakiri ,  Shigeki Satoh ,  Yoshito Abe ,  Yuki Sawada ,  Takayuki Inoue ,  Hirokazu Tanaka

发明人： Teruo Oku ,  Hiroshi Kayakiri ,  Shigeki Satoh ,  Yoshito Abe ,  Yuki Sawada ,  Takayuki Inoue ,  Hirokazu Tanaka

IPC分类号： A61K314184

CPC分类号： C07D209/48 ,  C07D235/06 ,  C07D235/08 ,  C07D235/12 ,  C07D235/16 ,  C07D235/26 ,  C07D235/28 ,  C07D235/30 ,  C07D263/56 ,  C07D277/64 ,  C07D307/79 ,  C07D307/80 ,  C07D307/84 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07F7/1804

摘要： This invention relates to a heterocyclic compound of the formula wherein a group of the formula: is a group of the formula X is O, S or N-R5, R1 is lower alkyl, etc., R5 is hydrogen, lower alkyl, etc., R2 is hydrogen, halogen, lower alkyl, etc., R3 is halogen, lower alkyl, etc., R4 is amino optionally having suitable substituent(s), and A is lower alkylene, and a salt thereof, to processes for preparation thereof, and to a pharmaceutical composition comprising the same for the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.

摘要翻译： 本发明涉及下式的下式的杂环化合物：式X的基团是O，S或N-R 5，R 1是低级烷基等，R 5是氢，低级烷基等，R 2是 氢，卤素，低级烷基等，R 3为卤素，低级烷基等，R 4为任选具有合适取代基的氨基，A为低级亚烷基及其盐，其制备方法为 包含其用于预防和/或治疗缓激肽或其类似物介导的人或动物疾病的药物组合物。