公开(公告)号：US11013755B2

公开(公告)日：2021-05-25

申请号：US16499520

申请日：2018-04-06

Applicant: UNIVERSITÄTSKLINIKUM HAMBURG-EPPENDORF

Inventor： Eric Hesse ,  Hanna Taipaleenmäki ,  Hiroaki Saito

IPC: C12N15/11 ,  A61K31/711 ,  A61P19/10 ,  A61K38/29

Abstract: The invention relates to inhibitors of microRNAs 19a and 19b and their use for treating or preventing conditions or diseases which are associated with bone loss, in particular osteoporosis and osteogenesis imperfect (01). The inhibitors are also useful for inducing an anabolic effect in bone, either alone or when administered in combination with parathyroid hormone or a recombinant fragment thereof. The invention further relates to inhibitors of microRNAs 19a and 19b and their use for treating or preventing conditions or diseases which are associated with reduced muscle function, in particular muscle degeneration and muscle atrophy. The inhibitors are also useful for stabilizing and/or strengthening muscle function. In addition, inhibitors of microRNAs 19a and 19b can be used for treating or preventing cancer-related bone destruction or bone metastasis.

公开(公告)号：US20210145006A1

公开(公告)日：2021-05-20

申请号：US17105392

申请日：2020-11-25

Applicant: SNIPR Technologies Limited

Inventor： Jasper CLUBE

IPC: A01N63/00 ,  C12N15/113 ,  C12N15/74 ,  C12N15/70 ,  A61K31/711 ,  A61K45/06 ,  A61K31/7105 ,  C12N15/10 ,  C12N9/16 ,  A61K35/74 ,  C12N15/90 ,  A61K48/00 ,  C12N1/20 ,  C12N7/00

Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.

公开(公告)号：US10967000B2

公开(公告)日：2021-04-06

申请号：US14413732

申请日：2013-07-11

Applicant: GemVax & KAEL Co., Ltd. ,  Sang Jae Kim

Inventor： Sang Jae Kim

IPC: C07K7/08 ,  A61K31/711 ,  A61K49/00 ,  A61K47/64 ,  A61K31/713 ,  A61K48/00 ,  A61K49/14 ,  A61K38/00

Abstract: The present invention relates to a conjugate of cell penetrating peptide and an active ingredient; and its use. Specifically, a conjugate including a cell penetrating peptide which is a peptide comprising amino acid sequence of SEQ ID NO:1, a fragment of any one sequence of SEQ ID NO:1, or a peptide having above 80% homology with the above-mentioned sequence; and a composition comprising the same are disclosed.

公开(公告)号：US20210079346A1

公开(公告)日：2021-03-18

申请号：US17034999

申请日：2020-09-28

Applicant: CellScript, LLC

Inventor： Cynthia Chin ,  Anthony D. Person ,  Gary A. Dahl

IPC: C12N5/078 ,  A61K38/16 ,  C07K14/705 ,  C07K14/715 ,  C07K14/005 ,  A61K31/7105 ,  A61K38/17 ,  A61K38/21 ,  A61K31/711 ,  C12N5/077 ,  C12N5/074

Abstract: The present invention provides methods, kits, and compositions for reducing an innate immune system response in a human or animal cell, tissue or organism. One embodiment comprises: introducing an Agent mRNA comprising in vitro-synthesized mRNA encoding one or more proteins that affect the induction, activity or response of an innate immune response pathway; whereby, the innate immune response in the cell, tissue or organism is reduced compared to the innate immune response in the absence of the Agent mRNA. Other embodiments are methods, compositions and kits for using an Agent mRNA for treating a disease or medical condition in a human or animal that exhibits symptoms of an elevated innate immune system, or for reducing an innate immune response that is induced in a human or animal cell, tissue or organism by a Foreign Substance that is administered to the cell, tissue or organism.

公开(公告)号：US20210052622A1

公开(公告)日：2021-02-25

申请号：US16942328

申请日：2020-07-29

Applicant: GENTIUM S.R.L.

Inventor： Massimo IACOBELLI

IPC: A61K31/711 ,  C12N15/11 ,  A61K31/7088 ,  A61K9/00 ,  A61K9/08

Abstract: Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD) in humans is disclosed, preferably in hematopoietic stem cell transplantation (HSCT), more preferably allogeneic hematopoietic stem cell transplantation. Graft versus Host Disease of the invention (GVHD) can be acute aGVHD and/or chronic cGVHD, preferably acute.

公开(公告)号：US10913768B2

公开(公告)日：2021-02-09

申请号：US15761957

申请日：2016-09-20

Applicant: TRILINK BIOTECHNOLOGIES, INC.

Inventor： Richard I. Hogrefe ,  Alexandre Lebedev ,  Anton P. McCaffrey ,  Dongwon Shin

IPC: C07H21/02 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/711 ,  A23L33/13 ,  C12N15/11 ,  C12P19/34

Abstract: Provided herein are methods and compositions for synthesizing 5′Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2′Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.

公开(公告)号：US10912791B2

公开(公告)日：2021-02-09

申请号：US16333046

申请日：2017-09-11

Applicant: The Board of Regents of the University of Texas System

Inventor： Connie Hsia ,  Orson W. Moe ,  Kytai Nguyen

IPC: A61K31/711 ,  A61P11/00 ,  A61K9/00 ,  A61K9/51 ,  C12N15/113 ,  C07K14/715 ,  C12N15/88

Abstract: Provided herein are nanoparticles comprising antisense-encoded erythropoietin receptor (RopE) alone or in combination with erythropoietin receptor (EpoR). Also provided herein are methods of treating or preventing lungs disorders comprising administering RopE alone or in combination with EpoR.

公开(公告)号：US10793856B2

公开(公告)日：2020-10-06

申请号：US15593173

申请日：2017-05-11

Applicant: Biogen MA Inc.

Inventor： Holly Kordasiewicz ,  Eric E. Swayze ,  Susan M. Freier ,  Huynh-Hoa Bui

IPC: C12N15/113 ,  A61K31/711 ,  C07H21/02 ,  C12Q1/68

Abstract: Disclosed herein are antisense compounds and methods for decreasing Tau mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Tau-associated diseases, disorders, and conditions.

公开(公告)号：US10793831B2

公开(公告)日：2020-10-06

申请号：US15823869

申请日：2017-11-28

Applicant: CellScript, LLC

Inventor： Cynthia Chin ,  Anthony D. Person ,  Gary A. Dahl

IPC: C12N5/078 ,  A61K38/16 ,  C07K14/705 ,  C07K14/715 ,  C07K14/005 ,  A61K31/7105 ,  A61K38/17 ,  A61K38/21 ,  A61K31/711 ,  C12N5/077 ,  C12N5/074

Abstract: The present invention provides methods, kits, and compositions for reducing an innate immune system response in a human or animal cell, tissue or organism. One embodiment comprises: introducing an Agent mRNA comprising in vitro-synthesized mRNA encoding one or more proteins that affect the induction, activity or response of an innate immune response pathway; whereby, the innate immune response in the cell, tissue or organism is reduced compared to the innate immune response in the absence of the Agent mRNA. Other embodiments are methods, compositions and kits for using an Agent mRNA for treating a disease or medical condition in a human or animal that exhibits symptoms of an elevated innate immune system, or for reducing an innate immune response that is induced in a human or animal cell, tissue or organism by a Foreign Substance that is administered to the cell, tissue or organism.

公开(公告)号：US20200297867A1

公开(公告)日：2020-09-24

申请号：US16074504

申请日：2017-02-01

Applicant: EXICURE,INC.

Inventor： Richard Kang ,  Sagar Anantatmula ,  Rishika Agarwal ,  Merideth Burkhart ,  Bart Anderson

IPC: A61K47/69 ,  A61K9/127 ,  A61K31/711

Abstract: The invention relates to a method of synthesizing liposomes and liposomal spherical nucleic acids with hydrophobic molecules functionalized to the surface. The lipid particles contain one or more agents that elicit an immune response.