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公开(公告)号：US11813458B2
公开(公告)日：2023-11-14
申请号：US17653814
申请日：2022-03-07
Inventor： Rosana Esteller , Mahsa Malekmohammadi , Andrew Haddock , Tianhe Zhang
CPC classification number: A61N1/3614 , A61N1/0534
Abstract: Methods and systems are described for detecting if a stimulation lead implanted in a patient's brain has moved. Lead movement occurring between a first time and a second time may be determined by comparing features extracted from evoked potentials recorded at the two times. The disclosed methods and systems are particularly useful for determining if a stimulation lead has moved between the time it was implanted in the patient's brain and the time that stimulation parameters are being optimized. Lead movement during implantation, during parameter optimization, and during or between other lead optimization processes may be determined as well.
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52.发明公开公开(公告)号：US20230355992A1
公开(公告)日：2023-11-09
申请号：US18223984
申请日：2023-07-19
Inventor： David Blum , Sherry Lin , Hemant Bokil , Michael A. Moffitt
CPC classification number: A61N1/37247 , A61N1/36132 , A61N1/025 , A61N1/36125 , A61N1/36139 , A61N1/37241 , A61N1/0551
Abstract: A method or system for facilitating the determining and setting of stimulation parameters for programming an electrical stimulation system using closed loop programming is provided. For example, pulse generator feedback logic is executed by a processor to interface with control instructions of an implantable pulse generator by incorporating one or more machine learning engines to automatically generate a proposed set of stimulation parameter values that each affect a stimulation aspect of the implantable pulse generator, receive one or more clinical responses and automatically generate a revised set of values taking into account the received clinical responses, and repeating the automated receiving of a clinical response and adjusting the stimulation parameter values taking the clinical response into account, until or unless a stop condition is reach or the a therapeutic response is indicated within a designated tolerance.
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公开(公告)号：US20230355979A1
公开(公告)日：2023-11-09
申请号：US18144704
申请日：2023-05-08
Inventor： Ismael Huertas Fernandez , Que T. Doan
CPC classification number: A61N1/36071 , A61N1/36062 , A61N1/37247 , A61N1/36185 , A61N1/36132
Abstract: Systems and methods for controlling autonomic symptoms or side effects via spinal cord stimulation are discussed. An exemplary neuromodulation system comprises an electrostimulator to provide spinal cord stimulation (SCS) to a neural target, a user interface device to receive a user input including an autonomic symptom and affected anatomy, and a controller circuit to determine or adjust a stimulation parameter based at least on the autonomic symptoms and the affected anatomy. Spinal cord stimulation can be delivered in accordance with the determined or adjusted stimulation parameter to alleviate the autonomic symptom, or to treat or alleviate autonomic disorders.
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公开(公告)号：US20230355978A1
公开(公告)日：2023-11-09
申请号：US18298024
申请日：2023-04-10
Inventor： Ismael Huertas Fernandez , Que T. Doan
CPC classification number: A61N1/36062 , A61N1/36175 , A61N1/37247
Abstract: Systems and methods for controlling an implantable stimulator device such as a spinal cord stimulation are disclosed. Optimal stimulation parameters for the patient, which may be personalized for the patient based on test stimulation and organized as a neural dose, are subject to duty cycling in which stimulation is applied during an on duration and is turned off during an off duration. The duty cycling applied is automatically determined by and dependent on the stimulation parameters chosen, and in particular the frequency of those parameters. Further, a user interface element is provided to allow a user to automatically step thought suitable duty cycle values determined to be appropriate for the stimulation parameters. As such, the user does need not need to engage in guess work to specify individual on and off times when duty cycling is desired.
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55.发明授权公开(公告)号：US11806547B2
公开(公告)日：2023-11-07
申请号：US17463206
申请日：2021-08-31
Inventor： Joshua Dale Howard
IPC: A61N5/06 , F21V5/04 , F21W131/20
CPC classification number: A61N5/0601 , F21V5/041 , A61N2005/063 , A61N2005/0626 , F21V2200/10 , F21W2131/20
Abstract: An implantable light generation arrangement for an optical or optical/electrical stimulation system includes a light source having an emission surface, wherein the light source is configured to generate light and emit the light from the emission surface; an optical waveguide having a first end and a core; a ball lens disposed between the light source and the optical waveguide and configured to receive the light emitted from the light source and direct the light onto the core at the first end of the optical waveguide; and a fixture holding the light source, optical waveguide, and ball lens in a fixed arrangement.
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Patent Agency Ranking
公开(公告)号：US20230347151A1
公开(公告)日：2023-11-02
申请号：US18218951
申请日：2023-07-06
Inventor： James R. Kozloski , Anup Kalia , Jeffrey Rogers , Sara E. Berger
CPC classification number: A61N1/36132 , G16H20/40 , A61N1/025 , A61N1/36071 , A61N1/36135 , A61N1/36175 , A61N1/36189
Abstract: Systems and techniques are disclosed to establish programming of an implantable electrical neurostimulation device for treating pain of a human subject, through the use and adjustment of analgesic stimulation parameters based on trust dynamics and trust measurements. In an example, the system to establish programming of the neurostimulation device performs operations that: determine a trust measurement value that is derived from results of at least one commitment made with a human subject, via observable interactions; determine a modification of at least one neurostimulation programming parameter, based on the trust measurement value; and to cause the implantable neurostimulation device to implement the modification of the at least one neurostimulation programming parameter. Further examples are provided to produce and track the trust measurement value, as well as identify a pain susceptibility value and determine a receptiveness to analgesic effects based on these and other trust dynamics.
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公开(公告)号：US11801389B2
公开(公告)日：2023-10-31
申请号：US17004209
申请日：2020-08-27
Inventor： Dheerendra Raghavendra Kashyap , Sarvani Grandhe , Natalie A. Brill , Bradley Lawrence Hershey , Changfang Zhu , Sridhar Kothandaraman , Dennis Zottola , Michael A. Moffitt
CPC classification number: A61N1/37247 , A61N1/0551 , A61N1/36071 , A61N1/36142 , A61N1/36182 , A61N1/36185 , G16H20/30 , G16H40/63 , A61N1/36062
Abstract: A neuromodulation customization system includes a field definition user interface, a neuromodulation signaling engine, and a supervisor engine. The field definition user interface is to facilitate entry of a customized electrotherapy field definition, with the field definition user interface including a set of input controls for defining field shape, field intensity, and field steering parameters of the customized electrotherapy field. The neuromodulation signaling engine is to produce commands for neuromodulation output circuitry to control generation of a customized electrotherapy field via a set of electrodes based on the customized electrotherapy field definition. The supervisor engine is to assess compliance of the customized electrotherapy field to be generated with applicable predefined criteria, and to modify generation of the customized electrotherapy field in response to an assessed non-compliance with the criteria.
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公开(公告)号：US11794017B2
公开(公告)日：2023-10-24
申请号：US17659960
申请日：2022-04-20
Inventor： Goran N. Marnfeldt
CPC classification number: A61N1/36185 , A61N1/36157 , A61N1/37241 , A61N1/37247 , A61N1/37288
Abstract: A field measurement algorithm and measuring circuitry in an implantable stimulator, and an field modelling algorithm operable in an external device, are used to determine an electric field in a patient's tissue. The field measuring algorithm provides at least one test current between two electrodes, and a plurality of voltage differentials are measured at different combinations of the electrodes. The voltage differential data is telemetered to the field modelling algorithm which determines directional resistance at different locations in the patient's tissue. The field modelling algorithm can then use a stimulation program selected for the patient and the determined directional resistances to determine voltages in the patient's tissue at various locations, which in turn can be used to model a more-accurate electric field in the tissue, and preferably to render an electric field image for display in a graphical user interface of the external device.
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59.发明授权公开(公告)号：US11794016B2
公开(公告)日：2023-10-24
申请号：US17137141
申请日：2020-12-29
Inventor： Rosana Esteller
CPC classification number: A61N1/36139 , A61B5/388 , A61N1/36062 , A61B2562/0219
Abstract: Methods and systems for providing closed loop control of stimulation provided by an implantable stimulator device are disclosed herein. The disclosed methods and systems use a neural feature prediction model to predict a neural feature, which is used as a feedback control variable for adjusting stimulation. The predicted neural feature is determined based on one or more signals from an accelerometer configured in contact with the patient. The disclosed methods and systems can be used to provide closed loop feedback in situations, such as sub-perception therapy, when neural features cannot be readily directly measured.
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公开(公告)号：US11786742B2
公开(公告)日：2023-10-17
申请号：US17205962
申请日：2021-03-18
Inventor： Joshua Dale Howard , Christopher Shanahan , Geoffrey Abellana Villarta , Peter J. Yoo
CPC classification number: A61N1/37241 , A61N1/05 , H01R4/28 , A61N1/0551 , A61N1/0595 , A61N1/3752
Abstract: An operating room cable assembly for electrically coupling at least one implantable electrical stimulation lead to a trial stimulator includes an elongated body; a trial stimulator connector disposed at one end of the elongated body; and a lead connector disposed at another end of the elongated body. The lead connector can include one or more buttons that can be pushed to load a lead into the lead connector and released to retain the lead. Alternatively, the lead connector can include a lever that can be operated to load the lead. A further alternative is a slider with a lead engagement element that can be slid between positions allowing loading of a lead and engagement of the lead. Other alternatives include a lead connector with doors that can swing open to allow loading of a lead or a collet/sleeve that can be tightened on the lead.
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