公开(公告)号：US20100256700A1

公开(公告)日：2010-10-07

申请号：US12755041

申请日：2010-04-06

申请人： Allan C. Shuros ,  Craig Stolen ,  Shantha Arcot-Krishnamurthy

发明人： Allan C. Shuros ,  Craig Stolen ,  Shantha Arcot-Krishnamurthy

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36521 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/3702

摘要： A method and device are described for delivering cardiac therapy in which an implantable device for delivering such cardiac therapy is additionally configured to detect the presence of inflammation. Upon detection of inflammation, the device may be configured to modify its delivery of therapy in various ways and/or to communicate the information to an external agent for other types of interventions.

摘要翻译： 描述了用于递送心脏疗法的方法和装置，其中用于递送这种心脏治疗的可植入装置另外配置为检测炎症的存在。 在检测到炎症时，该装置可以被配置为以各种方式修改其治疗递送和/或将信息传达给外部代理以用于其他类型的干预。

公开(公告)号：US20100249860A1

公开(公告)日：2010-09-30

申请号：US12720246

申请日：2010-03-09

申请人： Allan C. Shuros ,  Eric A. Mokelke ,  James A. Esler

发明人： Allan C. Shuros ,  Eric A. Mokelke ,  James A. Esler

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/3625 ,  A61N1/3627 ,  A61N1/37247 ,  A61N1/3925 ,  A61N1/3968 ,  A61N1/3993

摘要： An external cardiac stimulation patch integrates a transcutaneous cardiac stimulation device and body-surface electrodes with a skin patch. The skin patch is to be attached onto a patient to provide for electrical contacts between the body-surface electrodes and a patient. The transcutaneous cardiac stimulation device delivers pacing pulses to the heart of the patient through pacing electrodes selected from the body-surface electrodes.

摘要翻译： 外部心脏刺激贴片将经皮心脏刺激装置和体表电极与皮肤贴片集成。 将皮肤贴片贴在患者身上，以提供身体表面电极与患者之间的电接触。 经皮心脏刺激装置通过选自身体表面电极的起搏电极将起搏脉冲提供给患者的心脏。

公开(公告)号：US20100087881A1

公开(公告)日：2010-04-08

申请号：US12573520

申请日：2009-10-05

申请人： Allan C. Shuros ,  Barun Maskara ,  Shantha Arcot-Krishnamurthy

发明人： Allan C. Shuros ,  Barun Maskara ,  Shantha Arcot-Krishnamurthy

IPC分类号： A61N1/368 ,  A61N1/365 ,  A61N1/39

CPC分类号： A61N1/3622 ,  A61N1/3624 ,  A61N1/3684 ,  A61N1/395 ,  A61N1/3962

摘要： A pacing device and method for operating same is disclosed in which the point of origin of an arrhythmia is estimated in order to more provide more effective treatment. The origin of an arrhythmia may be estimated by analyzing the timing of electrical events as detected at different electrode sites and/or using different sensing vectors. Anti-tachycardia pacing (ATP) may then be delivered to the most appropriate location.

摘要翻译： 公开了用于操作的起搏装置和方法，其中估计心律失常的起点，以便更有效地提供治疗。 可以通过分析在不同电极位置处检测到的电气事件的定时和/或使用不同的感测向量来估计心律失常的起因。 然后将抗心动过速起搏（ATP）送至最合适的位置。

公开(公告)号：US20090264716A1

公开(公告)日：2009-10-22

申请号：US12425193

申请日：2009-04-16

申请人： Allan C. Shuros ,  Dan Li

发明人： Allan C. Shuros ,  Dan Li

IPC分类号： A61N1/365 ,  A61B5/0205 ,  A61B5/00 ,  A61N1/39

CPC分类号： A61N1/36585 ,  A61B5/02028 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/3962

摘要： This document discusses, among other things, an apparatus comprising an implantable hemodynamic sensor circuit that provides a hemodynamic signal representative of mechanical function of a cardiovascular system of a subject and a controller circuit communicatively coupled to the hemodynamic sensor circuit. The controller circuit includes a detection module configured to detect an onset of tachyarrhythmia, a signal analyzer module configured to determine a measure of morphological variability of the hemodynamic signal during the episode of tachyarrhythmia, and a rhythm discrimination module configured to deem whether the tachyarrhythmia episode is indicative of ventricular tachycardia (VT) according to the measure of morphological variability.

摘要翻译： 本文件尤其涉及一种包括可植入血液动力学传感器电路的装置，其提供表示受试者的心血管系统的机械功能的血液动力学信号和通信地耦合到血液动力学传感器电路的控制器电路。 所述控制器电路包括检测模块，所述检测模块被配置为检测快速性心律失常的发作，信号分析器模块被配置为确定在快速性心律失常发作期间的血液动力学信号的形态变异性的度量;以及节律辨别模块，其被配置为认为是否发生快速性心律失常发作 根据形态变异性的测量指示室性心动过速（VT）。

公开(公告)号：US20090234409A1

公开(公告)日：2009-09-17

申请号：US12396132

申请日：2009-03-02

申请人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy

发明人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/02405 ,  A61B5/0452 ,  A61B5/4035 ,  A61B5/4047 ,  A61N1/36114 ,  A61N1/36514 ,  A61N1/36592

摘要： Various system embodiments comprise a myocardial stimulator, at least one sensor adapted for use in detecting heart rate to determine heart rate turbulence (HRT), and a controller connected to the myocardial stimulator and the at least one sensor. The myocardial stimulator is adapted to deliver pacing pulses through at least one electrode to provide cardiac pacing. The controller is adapted to intermittently deliver a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The controller is further adapted to determine HRT from the detected heart rate to assess cardiac stress to the stress-inducing pacing pulses, and adjust at least one parameter of the stress-inducing pacing pulses to adjust cardiac stress if the cardiac stress to the stress-inducing pacing pulses is undesirable.

摘要翻译： 各种系统实施例包括心肌刺激器，适于用于检测心率以确定心率湍流（HRT）的至少一个传感器，以及连接到心肌刺激器和至少一个传感器的控制器。 心肌刺激器适于通过至少一个电极输送起搏脉冲以提供心脏起搏。 控制器适于间歇地递送一系列应力诱导起搏脉冲，其适于在应力引发起搏期间增加交感神经张力。 所述控制器进一步适于根据检测到的心率来确定HRT以评估心脏应激对应激引起的起搏脉冲，并且如果对于应力诱发起搏脉冲的心脏应力，则调整应力诱发起搏脉冲的至少一个参数以调节心脏应激， 引起起搏脉冲是不期望的。

公开(公告)号：US20090234401A1

公开(公告)日：2009-09-17

申请号：US12405990

申请日：2009-03-17

申请人： John R. Zielinski ,  Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Jeffrey E. Stahmann ,  Allan C. Shuros

发明人： John R. Zielinski ,  Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Jeffrey E. Stahmann ,  Allan C. Shuros

IPC分类号： A61N1/39 ,  A61N1/365 ,  A61N1/37

CPC分类号： A61N1/3627 ,  A61N1/368 ,  A61N1/3688 ,  A61N1/3962

摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when pacing is changed from the normal operating mode to a stress augmentation mode. The pacing mode controller suspends the change from the normal operating mode to the stress augmentation mode when a condition to prevent the change is detected.

摘要翻译： 本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。 起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。 与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。 当起搏从正常操作模式改变为应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替。 当检测到防止变化的条件时，起搏模式控制器将更改从正常操作模式暂停到应力增强模式。

公开(公告)号：US07526337B2

公开(公告)日：2009-04-28

申请号：US11422417

申请日：2006-06-06

申请人： Allan C. Shuros ,  Michael J. Kane

发明人： Allan C. Shuros ,  Michael J. Kane

IPC分类号： A61N1/365

CPC分类号： A61B5/03 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/14546 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4839 ,  A61N1/3627 ,  A61N1/36514

摘要： A device and method are disclosed for physiological monitoring of the lymphatic system. An implantable device is configured with a lymphatic sensor disposed in a lymphatic vessel for sensing pressure, flow, and/or the concentration of particular markers within the vessel. The device may be further configured to deliver appropriate therapy in accordance with the lymphatic monitoring.

摘要翻译： 公开了用于淋巴系统的生理监测的装置和方法。 可植入装置配置有设置在淋巴管中的淋巴传感器，用于感测容器内的特定标记物的压力，流量和/或浓度。 该装置还可以被配置成根据淋巴监测进行适当的治疗。

公开(公告)号：US20080221636A1

公开(公告)日：2008-09-11

申请号：US11682448

申请日：2007-03-06

申请人： Joseph M. Pastore ,  Tamara Colette Baynham ,  Donald L. Hopper ,  Allan C. Shuros ,  Shantha Arcot-Krishnamurthy

发明人： Joseph M. Pastore ,  Tamara Colette Baynham ,  Donald L. Hopper ,  Allan C. Shuros ,  Shantha Arcot-Krishnamurthy

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36514 ,  A61N1/36521 ,  A61N1/36585

摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac pacing to create or augment regional stress in the heart. The cardiac pacing is delivered intermittently, such as on a periodic basis, according to a cardiac stress augmentation pacing sequence that includes alternating pacing and non-pacing periods. One or more physiological signals are monitored for closed-loop control of the cardiac pacing using baseline characteristics of the cardiac disorder, acute cardiac stress created by the cardiac pacing, and/or risk associated with the cardiac pacing.

摘要翻译： 心脏起搏系统通过递送心脏起搏来创建或增加心脏中的区域应力来控制心脏病症如心力衰竭的进展。 根据包括交替起搏和非起搏期的心脏应激增加起搏序列，间歇地递送心脏起搏，例如周期性地起搏。 使用心脏病症的基线特征，由心脏起搏产生的急性心脏应激和/或与心脏起搏相关的风险来监测一个或多个生理信号用于心脏起搏的闭环控制。

公开(公告)号：US20080119904A1

公开(公告)日：2008-05-22

申请号：US11561049

申请日：2006-11-17

申请人： Rodney W. Salo ,  Allan C. Shuros ,  Tamara Colette Baynham

发明人： Rodney W. Salo ,  Allan C. Shuros ,  Tamara Colette Baynham

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.

摘要翻译： 描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。 在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。 在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。

公开(公告)号：US20080114408A1

公开(公告)日：2008-05-15

申请号：US11559131

申请日：2006-11-13

申请人： Allan C. Shuros ,  Joseph M. Pastore ,  Jeffrey A. Von Arx ,  Julio C. Spinelli ,  William J. Linder

发明人： Allan C. Shuros ,  Joseph M. Pastore ,  Jeffrey A. Von Arx ,  Julio C. Spinelli ,  William J. Linder

IPC分类号： A61N1/37

CPC分类号： A61N1/3627 ,  A61N1/36542 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/37205

摘要： A device and method for delivering pacing therapy to the heart in order to improve cardiac function in heart failure and post-MI patients. The pacing therapy is delivered in a manner that mimics the effects of exercise and improves symptoms even in patients who are exercise intolerant. The simulated exercise pacing may be delivered on an intermittent basis in accordance with a defined schedule and/or in response to detected conditions or events.

摘要翻译： 用于向心脏输送起搏治疗以改善心力衰竭和MI后患者的心脏功能的装置和方法。 起搏疗法以模仿运动效果的方式进行，甚至在运动不耐受的患者中也能改善症状。 可以根据定义的时间表和/或响应于检测到的条件或事件以间歇的方式递送模拟锻炼起搏。