公开(公告)号：US5693811A

公开(公告)日：1997-12-02

申请号：US669895

申请日：1996-06-21

Applicant: Kyle J. Lindstrom

Inventor： Kyle J. Lindstrom

IPC: C07D471/04 ,  C07D401/14

CPC classification number: C07D471/04

Abstract: A process for preparing 6, 7, 8, 9-tetrahydro-1H-imidazo�4,5-c!quinolin-4-amines is disclosed. The process involves the reduction of a 1H-imidazo�4,5-c!quinolin-4-amine or of a 6H-imidazo�4,5-c!tetrazolo�1,5-a!quinoline.

Abstract translation: 公开了制备6,7,8,9-四氢-1H-咪唑并[4,5-c]喹啉-4-胺的方法。 该方法包括还原1H-咪唑并[4,5-c]喹啉-4-胺或6H-咪唑并[4,5-c]四唑并[1,5-a]喹啉。

公开(公告)号：US5644063A

公开(公告)日：1997-07-01

申请号：US455285

申请日：1995-05-31

Applicant: Kyle J. Lindstrom ,  Nick Nikolaides

Inventor： Kyle J. Lindstrom ,  Nick Nikolaides

IPC: C07D213/69 ,  C07D213/74 ,  C07D213/75 ,  C07D471/04 ,  C07D213/62 ,  C07D213/70 ,  C07D213/72

CPC classification number: C07D213/69 ,  C07D213/74 ,  C07D213/75 ,  C07D471/04

Abstract: Imidazo[4,5-c]pyridin-4-amines that induce interferon (.alpha.) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (.alpha.) biosynthesis involving the use of such compounds.

Abstract translation: 在人细胞中诱导干扰素（α）生物合成的咪唑并[4,5-c]吡啶-4-胺。 还公开了含有这些化合物的药物组合物和诱导涉及使用这些化合物的干扰素（α）生物合成的方法。

公开(公告)号：US09383482B2

公开(公告)日：2016-07-05

申请号：US13639902

申请日：2011-05-03

Applicant: Christopher B. Walker, Jr. ,  Christopher P. Tebow ,  Tri D. Pham ,  Steven H. Kong ,  Joseph T. Aronson ,  Kyle J. Lindstrom ,  Michael K. Gerlach ,  Michelle L. Toy ,  Taun L. McKenzie ,  Anthony M. Renstrom ,  Robert A. Yapel ,  Mitchell A. F. Johnson

Inventor： Christopher B. Walker, Jr. ,  Christopher P. Tebow ,  Tri D. Pham ,  Steven H. Kong ,  Joseph T. Aronson ,  Kyle J. Lindstrom ,  Michael K. Gerlach ,  Michelle L. Toy ,  Taun L. McKenzie ,  Anthony M. Renstrom ,  Robert A. Yapel ,  Mitchell A. F. Johnson

IPC: G02B1/118 ,  G02B5/02

CPC classification number: G02B1/118 ,  G02B5/0242

Abstract: The present invention concerns antireflective films comprising a high refractive index layer (60) and low refractive index layer (80) disposed on the high refractive index layer. The antireflective films have a microstructured surface (70) that can be derived from a microreplicated tool.

Abstract translation: 本发明涉及包括设置在高折射率层上的高折射率层（60）和低折射率层（80）的抗反射膜。 抗反射膜具有可从微复制工具衍生的微结构化表面（70）。

公开(公告)号：US08343993B2

公开(公告)日：2013-01-01

申请号：US11885007

申请日：2006-02-22

Applicant: Tushar A. Kshirsagar ,  Scott E. Langer ,  Shri Niwas ,  George W. Griesgraber ,  Philip D. Heppner ,  Kyle J. Lindstrom

Inventor： Tushar A. Kshirsagar ,  Scott E. Langer ,  Shri Niwas ,  George W. Griesgraber ,  Philip D. Heppner ,  Kyle J. Lindstrom

IPC: A61K31/4375 ,  C07D513/16

CPC classification number: C07D471/14

Abstract: Certain imidazonaphthyridines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-α biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 某些具有2-位羟基甲基或羟乙基取代基的咪唑并吡啶类，含有化合物的药物组合物，中间体，制备方法以及这些化合物作为免疫调节剂的使用方法，用于优先诱导动物中的IFN-α生物合成和治疗疾病 包括病毒和肿瘤疾病。

公开(公告)号：US20120064296A1

公开(公告)日：2012-03-15

申请号：US13322231

申请日：2010-05-28

Applicant: Christopher B. Walker, JR. ,  Christopher P. Tebow ,  Tri D. Pham ,  Steven H. Kong ,  Joseph T. Aronson ,  Kyle J. Lindstrom ,  Michael K. Gerlach ,  Michelle L. Toy ,  Taun L. McKenzie ,  Anthony M. Renstrom ,  Slah Jendoubi ,  Mitchell A.F. Johnson ,  Scott R. Kaytor ,  Robert A. Yapel ,  Joseph A. Zigal ,  Steven J. McMan ,  Steven D. Solomonson ,  Fei Lu ,  Gary T. Boyd

Inventor： Christopher B. Walker, JR. ,  Christopher P. Tebow ,  Tri D. Pham ,  Steven H. Kong ,  Joseph T. Aronson ,  Kyle J. Lindstrom ,  Michael K. Gerlach ,  Michelle L. Toy ,  Taun L. McKenzie ,  Anthony M. Renstrom ,  Slah Jendoubi ,  Mitchell A.F. Johnson ,  Scott R. Kaytor ,  Robert A. Yapel ,  Joseph A. Zigal ,  Steven J. McMan ,  Steven D. Solomonson ,  Fei Lu ,  Gary T. Boyd

IPC: B32B3/10 ,  B82Y20/00

CPC classification number: G02B5/02 ,  G02F1/133502 ,  G02F2202/36 ,  Y10T428/24355 ,  Y10T428/24372

Abstract: The present invention concerns antiglare films having a microstructured surface.

Abstract translation: 本发明涉及具有微结构化表面的防眩膜。

公开(公告)号：US20090030031A1

公开(公告)日：2009-01-29

申请号：US11884982

申请日：2006-02-22

Applicant: Tushar A. Kshirsagar ,  Bryon A. Merrill ,  Scott E. Langer ,  Kyle J. Lindstrom ,  Sarah C. Slania ,  Gregory J. Marszalek ,  Joshua R. Wurst ,  Karl J. Manske ,  Shri Niwas ,  Gregory D. Lundquist, JR. ,  Philip D. Heppner ,  George W. Griesgraber ,  Michael E. Danielson

Inventor： Tushar A. Kshirsagar ,  Bryon A. Merrill ,  Scott E. Langer ,  Kyle J. Lindstrom ,  Sarah C. Slania ,  Gregory J. Marszalek ,  Joshua R. Wurst ,  Karl J. Manske ,  Shri Niwas ,  Gregory D. Lundquist, JR. ,  Philip D. Heppner ,  George W. Griesgraber ,  Michael E. Danielson

IPC: A61K31/4375 ,  A61K31/437 ,  A61P35/00 ,  A61P31/12

CPC classification number: A61K31/4745 ,  C07D471/04 ,  C07D471/14 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/481

Abstract: A method of preferentially inducing IFN-α biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-α biosynthesis in an animal are disclosed.

Abstract translation: 一种在动物中优先诱导IFN-α生物合成的方法，其包括在2-位上给予某些咪唑并[4,5-c]环化合物与羟甲基或羟乙基取代基或含有化合物，中间体，制备方法和 公开了使用这些化合物的免疫调节剂用于治疗疾病的方法，所述疾病包括在动物中优先诱导IFN-α生物合成的病毒和肿瘤疾病。

公开(公告)号：US20090029988A1

公开(公告)日：2009-01-29

申请号：US11885005

申请日：2006-02-22

Applicant: Tushar A. Kshirsagar ,  Bryon A. Merrill ,  Scott E. Langer ,  Kyle J. Lindstrom ,  Sarah JC. Slania ,  Gregory J. Marszalek ,  Karl J. Manske ,  Philip D. Heppner ,  Gregory D. Lundquist, JR.

Inventor： Tushar A. Kshirsagar ,  Bryon A. Merrill ,  Scott E. Langer ,  Kyle J. Lindstrom ,  Sarah JC. Slania ,  Gregory J. Marszalek ,  Karl J. Manske ,  Philip D. Heppner ,  Gregory D. Lundquist, JR.

IPC: A61K31/5377 ,  C07D471/04 ,  C07D413/14 ,  A61P35/00 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-α biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 含2-羟基甲基或羟乙基取代基的某些咪唑并喹啉，含有化合物的药物组合物，中间体，制备方法以及这些化合物作为免疫调节剂的使用方法，用于优先诱导动物中的IFN-α生物合成和治疗疾病 包括病毒和肿瘤疾病。

公开(公告)号：US20090018122A1

公开(公告)日：2009-01-15

申请号：US10595103

申请日：2004-08-27

Applicant: Kyle J. Lindstrom ,  Hugues M.H. Martin ,  Bryon A. Merrill ,  Michael J. Rice ,  Joshua R. Wurst ,  Chad A. Haraldson ,  Tushar A. Kshirsagar ,  Philip D. Heppner ,  Shri Niwas ,  George W. Griesgraber ,  Matthew R. Radmer

Inventor： Kyle J. Lindstrom ,  Hugues M.H. Martin ,  Bryon A. Merrill ,  Michael J. Rice ,  Joshua R. Wurst ,  Chad A. Haraldson ,  Tushar A. Kshirsagar ,  Philip D. Heppner ,  Shri Niwas ,  George W. Griesgraber ,  Matthew R. Radmer

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 在6,7,8或9位含有芳氧基或芳基亚烷基氧基或羟基取代基的咪唑并喹啉化合物含有这些化合物作为免疫调节剂的化合物，中间体和使用方法，用于调节动物中的细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：US07098221B2

公开(公告)日：2006-08-29

申请号：US11200556

申请日：2005-08-10

Applicant: Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

Inventor： Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC: A61K31/437 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06797718B2

公开(公告)日：2004-09-28

申请号：US10456308

申请日：2003-06-06

Applicant: Joseph F. Dellaria ,  Kyle J. Lindstrom ,  Luke T. Dressel ,  Philip D. Heppner ,  John R. Jacobsen ,  Matthew R. Radmer ,  Doris Stoermer

Inventor： Joseph F. Dellaria ,  Kyle J. Lindstrom ,  Luke T. Dressel ,  Philip D. Heppner ,  John R. Jacobsen ,  Matthew R. Radmer ,  Doris Stoermer

IPC: A61K31437

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.