公开(公告)号：US20100174347A1

公开(公告)日：2010-07-08

申请号：US12616057

申请日：2009-11-10

申请人： Robert S. Kieval ,  Bruce J. Persson ,  David J. Serdar ,  Peter T. Keith ,  Martin A. Rossing

发明人： Robert S. Kieval ,  Bruce J. Persson ,  David J. Serdar ,  Peter T. Keith ,  Martin A. Rossing

IPC分类号： A61N1/05

CPC分类号： A61N1/08 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/36007 ,  A61N1/36117 ,  A61N1/37229

摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize RF-coupled or other electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

摘要翻译： 公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。 控制系统可用于调节压力感受器激活装置。 控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。 压电感受器激活装置可以利用RF耦合或其它电极来激活压力感受器。 电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。

公开(公告)号：US07499747B2

公开(公告)日：2009-03-03

申请号：US11071602

申请日：2005-03-02

申请人： Robert S. Kieval ,  Martin A. Rossing

发明人： Robert S. Kieval ,  Martin A. Rossing

IPC分类号： A61N1/36

CPC分类号： A61N1/36017 ,  A61N1/0556 ,  A61N1/36114

摘要： Methods and systems for external baroreflex activation allow a physician to characterize a patient's response to baroreflex activation prior to providing baroreflex activation therapy. Methods generally include applying a baroreflex activation stimulus to a patient, measuring one or more physiological parameters of the patient, and determining the extent to which the baroreflex activation causes a baroreflex response. Multiple stimuli of different intensities and/or from different locations may be compared. Systems include one or more external baroreflex activation devices and one or more physiological parameter measuring devices. Optionally, a system may also include one or more fully or partially implantable devices for providing baroreflex activation therapy.

摘要翻译： 用于外部压力反射激活的方法和系统允许医师在提供压力反射激活治疗之前表征患者对压力反射激活的反应。 方法通常包括对患者施加压力反射激活刺激，测量患者的一个或多个生理参数，以及确定压力反射激活导致压力反射反应的程度。 可以比较不同强度和/或不同位置的多种刺激。 系统包括一个或多个外部压力反射激活装置和一个或多个生理参数测量装置。 任选地，系统还可以包括用于提供压力反射激活治疗的一个或多个完全或部分可植入装置。

公开(公告)号：US07499742B2

公开(公告)日：2009-03-03

申请号：US10402911

申请日：2003-03-27

申请人： Stephen L. Bolea ,  Robert S. Kieval ,  Bruce J. Persson ,  David J. Serdar ,  Peter T. Keith ,  Eric D. Irwin ,  Martin A. Rossing

发明人： Stephen L. Bolea ,  Robert S. Kieval ,  Bruce J. Persson ,  David J. Serdar ,  Peter T. Keith ,  Eric D. Irwin ,  Martin A. Rossing

IPC分类号： A61B5/04 ,  A61N1/00

CPC分类号： A61N1/36117 ,  A61B5/02028 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/056 ,  A61N1/08 ,  A61N1/36053 ,  A61N1/3611 ,  A61N1/36114 ,  A61N1/36125 ,  A61N1/36135 ,  A61N1/36185 ,  A61N1/3702

摘要： Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

摘要翻译： 描述的装置，系统和方法通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。 控制系统可用于调节压力感受器激活装置。 控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。 压力感受器激活装置可以利用电极来激活压力感受器。 电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。

公开(公告)号：US20080288017A1

公开(公告)日：2008-11-20

申请号：US12038707

申请日：2008-02-27

申请人： Robert S. Kieval ,  Martin A. Rossing ,  Robert J. Cody

发明人： Robert S. Kieval ,  Martin A. Rossing ,  Robert J. Cody

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36014

摘要： Methods and systems for external baroreflex activation of a baroreceptor system of a patient from a stimulator external to the patient. The method and devices, enable baroflex therapy on a temporary basis and/or assess the response of a patient to such baroreflex therapy.

摘要翻译： 用于外部压力反射激活患者的压力感受器系统的方法和系统，其来自患者外部的刺激器。 该方法和装置能够暂时实现巴罗非司酮治疗和/或评估患者对这种压力反射治疗的反应。

公开(公告)号：US20080171923A1

公开(公告)日：2008-07-17

申请号：US11933302

申请日：2007-10-31

申请人： Stephen L. Bolea ,  Robert S. Kieval ,  Bruce J. Persson ,  David J. Serdar ,  Peter T. Keith ,  Eric D. Irwin ,  Martin A. Rossing

发明人： Stephen L. Bolea ,  Robert S. Kieval ,  Bruce J. Persson ,  David J. Serdar ,  Peter T. Keith ,  Eric D. Irwin ,  Martin A. Rossing

IPC分类号： A61B5/00

CPC分类号： A61N1/3686 ,  A61N1/05 ,  A61N1/08 ,  A61N1/36117 ,  A61N1/36185

摘要： An apparatus capable of being implanted in a patient's body, including a posture sensor, a heart rate sensor, and a processor coupled to the posture sensor and the heart rate sensor. The processor is configured to measure the patient's heart rate via the cardiac signal sensor, detect a change in a posture of the patient's body via the posture sensor, and determine an autonomic tone of the patient's body based on the patient's heart rate measured during a time period corresponding to the change in posture.

摘要翻译： 一种能够植入患者体内的装置，包括姿势传感器，心率传感器和耦合到姿势传感器和心率传感器的处理器。 处理器被配置为经由心脏信号传感器测量患者的心率，通过姿态传感器检测患者身体姿势的变化，并且基于在一段时间内测量的患者心率来确定患者身体的自主音调 对应于姿势变化的时期。

公开(公告)号：US07212856B2

公开(公告)日：2007-05-01

申请号：US10630002

申请日：2003-07-29

申请人： Martin A. Rossing

发明人： Martin A. Rossing

IPC分类号： A61N1/378

CPC分类号： A61N1/3975 ,  A61N1/3931 ,  A61N1/3956

摘要： The invention is directed to techniques for estimating a deformation factor of one or more capacitors in an implantable medical devices (IMD), and techniques for reforming such capacitors. An estimate of the ideal charge time is extrapolated from a first measured charge interval associated with charging the capacitor(s) to a first energy level. The actual charge time to associated with charging the capacitor(s) to a second energy level, e.g., the fully charged state, is measured. The deformation factor is calculated as a ratio of the actual charge interval to the second energy level to the ideal charge time. In some cases, the calculated deformation factor is used to adjust the timing of a future scheduled reformation of the capacitor(s).

摘要翻译： 本发明涉及用于估计可植入医疗装置（IMD）中的一个或多个电容器的变形因子的技术以及用于重建这种电容器的技术。 理想充电时间的估计是从与电容器充电到第一能量水平相关联的第一测量充电间隔外推的。 测量与将电容器充电至第二能量水平（例如，完全充电状态）相关联的实际充电时间。 变形系数被计算为实际充电间隔与第二能量水平与理想充电时间的比率。 在某些情况下，使用计算出的变形因子来调整电容器未来调试改造的时序。

公开(公告)号：US5464430A

公开(公告)日：1995-11-07

申请号：US372622

申请日：1995-01-13

申请人： Martin A. Rossing

发明人： Martin A. Rossing

IPC分类号： A61N1/37 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61N1/3962 ,  A61N1/3702

摘要： An automatic implantable device for detecting and differentiating between tachyarrhythmias in order to therapeutically stimulate the heart in response thereto, particularly for distinguishing fibrillation from tachycardia and to provide appropriate therapies for each condition. The event intervals between successive heart depolarizations are measured, stored and classified as within fibrillation or tachycardia interval ranges. The numbers of intervals falling within the fibrillation and tachycardia interval ranges are employed to distinguish fibrillation from tachycardia. The number of intervals required to detect and discriminate between tachycardia and fibrillation in situations where the tachyarrhythmia includes intervals in both interval ranges is reduced by adjusting the interval ranges as a function of the relative distribution of measured intervals within the interval ranges.

摘要翻译： 一种用于检测和区分快速性心律失常的自动植入装置，以便响应于此来治疗性地刺激心脏，特别是用于区分颤动与心动过速并为每种病症提供适当的治疗。 连续心脏去极化之间的事件间隔被测量，存储并分类为原纤维化或心动过速间期范围内。 使用落在原纤维性和心动过速间隔范围内的间隔数来区分颤动与心动过速。 通过将间隔范围调整为在间隔范围内的测量间隔的相对分布的函数来减少在两个间隔范围内包括间隔的快速性心律失常的情况下检测和区分心动过速和颤动所需的间隔数。

公开(公告)号：US4515159A

公开(公告)日：1985-05-07

申请号：US358172

申请日：1982-03-15

申请人： Ray S. McDonald ,  David L. Thompson ,  Martin A. Rossing ,  Jerome T. Hartlaub

发明人： Ray S. McDonald ,  David L. Thompson ,  Martin A. Rossing ,  Jerome T. Hartlaub

IPC分类号： A61N1/362 ,  A61N1/372 ,  A61N1/36

CPC分类号： A61N1/362 ,  A61N1/37252

摘要： A programmable cardiac pacemaker pulse generator utilizing digital circuitry for controlling the provision of cardiac stimulating pulses. The pulse generator is capable of having the rate, the pulse width, the pulse amplitude, the refractory period, the sensitivity and the mode of operation programmed. In addition, the pulse generator can have the output inhibited and can respond to programming signals causing a threshold margin test to be performed, effects of closure of the reed switch overridden, a hysteresis function added and a high rate exceeding the normal upper rate limit programmed. Many of the programmable functions of the pulse generator can either be programmed on a permanent or a temporary basis. The pulse generator further includes means for signaling the acceptance of a programming signal, and means to reset the program acceptance circuit if extraneous signals are detected as programming signals. The program signal acceptance circuit performs several different checks on the detected programming signal including a parity check, an access code check and determining if the proper number of signals were transmitted within a given time. The timing circuit of the pulse generator includes a crystal clock oscillator and counter means for counting the clock pulses therefrom to determine the rate of the pacemaker. The pulse width of each pacemaker pulse is determined by using a voltage controlled oscillator in place of the crystal oscillator to obtain energy compensation due to the battery voltage decreasing with time.

摘要翻译： 一种可编程心脏起搏器脉冲发生器，利用数字电路来控制提供心脏刺激脉冲。 脉冲发生器能够具有速率，脉冲宽度，脉冲幅度，不应期，灵敏度和编程方式。 此外，脉冲发生器可以禁止输出并且可以对编程信号做出响应，导致执行阈值余量测试，切换簧片开关的闭合效应，添加的滞后函数以及超过常规上限速率限制的高速率 。 脉冲发生器的许多可编程功能可以被永久地或临时地编程。 脉冲发生器还包括用于发信号通知编程信号的装置，以及如果外部信号被检测为编程信号则复位程序接受电路的装置。 程序信号接收电路对检测到的编程信号执行若干不同的检查，包括奇偶校验，访问码检查和确定在给定时间内是否传送了适当数量的信号。 脉冲发生器的定时电路包括晶体时钟振荡器和用于从其计数时钟脉冲的计数器装置，以确定起搏器的速率。 通过使用压控振荡器代替晶体振荡器来确定每个起搏器脉冲的脉冲宽度，以获得由于电池电压随时间而下降的能量补偿。

公开(公告)号：US4241736A

公开(公告)日：1980-12-30

申请号：US958317

申请日：1978-11-06

申请人： Martin A. Rossing ,  Ray S. McDonald

发明人： Martin A. Rossing ,  Ray S. McDonald

IPC分类号： A61N1/372 ,  A61N1/36

CPC分类号： A61N1/37252

摘要： A programmable cardiac pacemaker pulse generator utilizing digital circuitry for controlling the provision of cardiac stimulating pulses. The pulse generator is capable of having the rate, the pulse width, the pulse amplitude, the refractory period, the sensitivity and the mode of operation programmed. In addition, the pulse generator can have the output inhibited and can respond to programming signals causing a threshold margin test to be performed, effects of closure of the reed switch overriden, a hysteresis function added and a high rate exceeding the normal upper rate limit programmed. Many of the programmable functions of the pulse generator can either be programmed on a permanent or a temporary basis. The pulse generator further includes means for signaling the acceptance of a programming signal, and means to reset the program acceptance circuit if extraneous signals are detected as programming signals. The program signal acceptance circuit performs several different checks on the detected programming signal including a parity check, an access code check and determining if the proper number of signals were transmitted within a given time. The timing circuit of the pulse generator includes a crystal clock oscillator and counter means for counting the clock pulses therefrom to determine the rate of the pacemaker. The pulse width of each pacemaker pulse is determined by using a voltage controlled oscillator in place of the crystal oscillator to obtain energy compensation due to the battery voltage decreasing with time.

摘要翻译： 一种可编程心脏起搏器脉冲发生器，利用数字电路来控制提供心脏刺激脉冲。 脉冲发生器能够具有速率，脉冲宽度，脉冲幅度，不应期，灵敏度和编程方式。 此外，脉冲发生器可以禁止输出并且可以对编程信号进行响应，导致执行阈值裕量测试，簧片开关闭合的影响被覆盖，添加的滞后函数和超过正常上限速率限制的高速率 。 脉冲发生器的许多可编程功能可以被永久地或临时地编程。 脉冲发生器还包括用于发信号通知编程信号的装置，以及如果外部信号被检测为编程信号则复位程序接受电路的装置。 程序信号接收电路对检测到的编程信号执行若干不同的检查，包括奇偶校验，访问码检查和确定在给定时间内是否传送了适当数量的信号。 脉冲发生器的定时电路包括晶体时钟振荡器和用于从其计数时钟脉冲的计数器装置，以确定起搏器的速率。 通过使用压控振荡器代替晶体振荡器来确定每个起搏器脉冲的脉冲宽度，以获得由于电池电压随时间而下降的能量补偿。