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    METHOD FOR PRODUCING COENZYME Q10 BY FERMENTATION USING STOCK CULTURE FROM SOLID PHASE FERMENTATION
    54.
    发明申请
    METHOD FOR PRODUCING COENZYME Q10 BY FERMENTATION USING STOCK CULTURE FROM SOLID PHASE FERMENTATION 有权
    通过使用来自固相发酵的贮藏文化发酵生产聚苯乙烯Q10的方法

    公开(公告)号：US20130330789A1

    公开(公告)日：2013-12-12

    申请号：US14002199

    申请日：2011-04-26

    Applicant: Jinqing Chen ,  Dajun Chen ,  Junhuang Chen ,  Meiqiong Wu ,  Songgang Su ,  Jianzhong Huang ,  Yi Zheng

    Inventor： Jinqing Chen ,  Dajun Chen ,  Junhuang Chen ,  Meiqiong Wu ,  Songgang Su ,  Jianzhong Huang ,  Yi Zheng

    IPC: C12P7/66

    CPC classification number: C12P7/66 ,  C12N1/20 ,  C12R1/01

    Abstract: A method for producing coenzyme Q10 by using stock culture from solid phase fermentation. The strain used in this method is Rhodobacter sphaeroides. Strain passaging is carried out by culturing in a slant medium. After steam cooking and air drying, solid medium is subpackaged and sterilized, wherein said solid medium includes solid components and liquid components. The fresh culture of Rhodobacter sphaeroides on the slant medium is added with sterile water, and the resultant bacterial suspension is added into the solid medium, cultured and used as stock culture for primary fermentation. The method of the present invention can enhance the fermentation level of coenzyme Q10, reduce the cascades of fermentation, shorten production cycle, simplify production processes, and lower production cost.

    Abstract translation: 通过使用固相发酵的原料培养生产辅酶Q10的方法。 该方法中使用的菌株是球形红细菌。 菌株传代是通过在倾斜培养基中培养进行的。 在蒸汽烹饪和空气干燥之后，将固体培养基分包并灭菌，其中所述固体培养基包括固体组分和液体组分。 向斜面培养基上添加无菌水球状红细菌的新鲜培养物，将生成的细菌悬浮液加入到固体培养基中，培养并用作初级发酵的培养基。 本发明的方法可以提高辅酶Q10的发酵水平，降低发酵级联，缩短生产周期，简化生产工艺，降低生产成本。

    Fenceless main pole definition for advanced perpendicular magnetic write head
    55.
    发明授权
    Fenceless main pole definition for advanced perpendicular magnetic write head 有权
    无极主极定义用于高级垂直磁头写入头

    公开(公告)号：US08568601B2

    公开(公告)日：2013-10-29

    申请号：US11947616

    申请日：2007-11-29

    Applicant: Aron Pentek ,  Sue Siyang Zhang ,  Yi Zheng

    Inventor： Aron Pentek ,  Sue Siyang Zhang ,  Yi Zheng

    IPC: B44C1/22 ,  H01L21/00

    CPC classification number: G03B31/00

    Abstract: A method for manufacturing a magnetic write head for perpendicular magnetic recording. The method includes forming a write pole using a mask that includes a hard mask layer deposited over the write pole laminate material, and a thick, physically robust image transfer layer. The image transfer layer can be a material such as AlTiO that can be patterned by a reactive ion etching process, but which also resists deformation during processing. This process allows a write pole and wrap-around trailing shield to be constructed at very narrow track widths without the mask deformation and fencing problems experienced by prior art methods.

    Abstract translation: 一种用于制造用于垂直磁记录的磁写头的方法。 该方法包括使用掩模形成写入极，该掩模包括沉积在写磁极层压材料上的硬掩模层，以及厚的，物理上坚固的图像转印层。 图像转印层可以是诸如AlTiO的材料，其可以通过反应离子蚀刻工艺进行图案化，但也可以在加工过程中抵抗变形。 该过程允许在非常窄的轨道宽度上构造写极点和缠绕后挡板，而不会由现有技术方法遇到的掩模变形和围栏问题。

    Extended non-return-to-zero serial channel signaling
    57.
    发明授权
    Extended non-return-to-zero serial channel signaling 有权
    扩展的无归零串行通道信令

    公开(公告)号：US08422586B2

    公开(公告)日：2013-04-16

    申请号：US13400325

    申请日：2012-02-20

    Applicant: Yi Zheng ,  Joel R. Goergen

    Inventor： Yi Zheng ,  Joel R. Goergen

    IPC: H04L27/00

    CPC classification number: H04L25/4917 ,  H04L1/0063 ,  H04L25/4904 ,  H04L25/497

    Abstract: Methods and apparatus for serial channel operation are disclosed. An N+1-level signaling scheme is used to transmit N staggered but overlapping NRZ sub-sequences concurrently on a serial channel. Each sequence has a bit rate R and an essential bandwidth of R Hz. The combined bit rate of the channel is N×R, but due to a lack of correlation between the sub-sequences, the essential bandwidth remains approximately R Hz. The signaling scheme also contains redundancy that allows some errors to be detected and/or corrected. Other embodiments are also described and claimed.

    Abstract translation: 公开了串行通道操作的方法和装置。 N + 1级信令方案用于在串行信道上同时发送N个交错但重叠的NRZ子序列。 每个序列具有比特率R和R Hz的必要带宽。 信道的组合比特率为N×R，但是由于子序列之间缺乏相关性，基本带宽保持大致为R Hz。 信令方案还包含允许检测和/或校正一些错误的冗余。 还描述和要求保护其他实施例。

    Mobilization of hematopoietic stem cells
    58.
    发明授权
    Mobilization of hematopoietic stem cells 有权
    动员造血干细胞

    公开(公告)号：US08383124B2

    公开(公告)日：2013-02-26

    申请号：US12922026

    申请日：2009-03-12

    Applicant: Yi Zheng

    Inventor： Yi Zheng

    IPC: A61K39/00 ,  A01N25/00

    CPC classification number: A61K38/45 ,  A61K31/395 ,  A61K31/403 ,  A61K38/16 ,  A61K38/18 ,  A61K38/193 ,  A61K38/202 ,  A61K38/204 ,  A61K38/2073 ,  A61K38/44 ,  A61K45/06 ,  G01N33/5011 ,  G01N33/56966 ,  G01N2333/70596 ,  A61K2300/00

    Abstract: Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and/or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.

    Abstract translation: 本文提供了方法，方法，用途和药物组合物，用于将造血祖细胞和/或癌干细胞从骨髓转移到外周血中，包括施用有效量的GTP酶抑制剂，例如Cdc-42特异性 单独或与一种或多种另外的试剂组合。 具体地，公开了将造血干细胞移入受试者的外周血中的方法。 特别地，该方法的实施方案涉及Cdc42GTP酶的特异性抑制以将造血干细胞的数量增加到受试者的受试者的外周血中。

    Method for manufacturing a perpendicular magnetic write head having a leading edge tapered write pole, self aligned side shield and independent trailing shield
    59.
    发明授权
    Method for manufacturing a perpendicular magnetic write head having a leading edge tapered write pole, self aligned side shield and independent trailing shield 有权
    用于制造具有前缘锥形写极，自对准侧屏蔽和独立后屏蔽的垂直磁写头的方法

    公开(公告)号：US08347489B2

    公开(公告)日：2013-01-08

    申请号：US12874116

    申请日：2010-09-01

    Applicant: Liubo Hong ,  Aron Pentek ,  Yi Zheng ,  Honglin Zhu

    Inventor： Liubo Hong ,  Aron Pentek ,  Yi Zheng ,  Honglin Zhu

    IPC: G11B5/127 ,  H04R31/00

    CPC classification number: G11B5/3163 ,  G11B5/1278 ,  G11B5/23 ,  G11B5/3116 ,  G11B5/315 ,  Y10T29/49041 ,  Y10T29/49043 ,  Y10T29/49044 ,  Y10T29/49046 ,  Y10T29/49048 ,  Y10T29/49052

    Abstract: A method for manufacturing a magnetic write head having a tapered write pole as well as a leading edge taper, and independent trailing and side magnetic shields. The method allows the write pole to be constructed by a dry process wherein the write pole material is either deposited by a process such as sputter deposition or electrically plated and the write pole shape is defined by masking and ion milling. The write pole has a stepped feature that can either be used to provide increased magnetic spacing between the trailing shield and the write pole at a location slightly recessed from the ABS or can be magnetic material that increases the effective thickness of the write pole at a location slightly recessed from the ABS. A bump structure can be further built over that stepped feature to enhance field gradient as well as reduce trailing shield saturation.

    Abstract translation: 一种用于制造具有锥形写柱以及前缘锥形的磁写头的方法，以及独立的后侧和侧面磁屏蔽。 该方法允许写极通过干法进行构建，其中写极材料通过诸如溅射沉积或电镀的工艺沉积，并且写极形状通过掩模和离子铣削定义。 写极具有阶梯特征，其可以用于在稍微从ABS处凹陷的位置处在后屏蔽和写极之间提供增加的磁间隔，或者可以是磁性材料，其增加写极的位置处的有效厚度 从ABS略微凹进。 可以在该阶梯特征上进一步构建凸块结构，以增强磁场梯度以及减少后屏蔽饱和度。

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