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公开(公告)号：US10464952B2
公开(公告)日：2019-11-05
申请号：US16002363
申请日：2018-06-07
发明人： Christopher J. Burns , Daniel C. Pevear , Robert E. Lee Trout , Randy W. Jackson , Jodie Hamrick , Allison L. Zulli , Eugen F. Mesaros , Steven A. Boyd
IPC分类号： C07F5/02 , A61K31/69 , A61P31/04 , A61K45/06 , A61K31/427 , A61K31/43 , A61K31/545 , A61K31/546
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US10214547B2
公开(公告)日：2019-02-26
申请号：US15787224
申请日：2017-10-18
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US10125152B2
公开(公告)日：2018-11-13
申请号：US15675262
申请日：2017-08-11
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout , Randy W. Jackson
IPC分类号： C07F5/02 , A61K31/546 , A61K31/496 , A61K45/06 , A61K31/69 , A61K31/407
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20180194783A1
公开(公告)日：2018-07-12
申请号：US15787224
申请日：2017-10-18
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K9/0019 , A61K9/0053 , A61K31/69 , A61K45/06 , C07F5/027 , C07F5/04 , Y02A50/473
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20170073360A1
公开(公告)日：2017-03-16
申请号：US15261359
申请日：2016-09-09
发明人： Christopher J. BURNS , Bin LIU , Jiangchao YAO , Denis DAIGLE , Steven A. BOYD
CPC分类号： C07F5/025 , A61K31/407 , A61K31/546 , A61K31/69 , A61K45/06 , A61K2300/00
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
摘要翻译： 本文描述了调节β-内酰胺酶活性的化合物和组合物。 在一些实施方案中，本文所述的化合物抑制β-内酰胺酶。 在某些实施方案中，本文所述的化合物可用于治疗细菌感染。
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公开(公告)号：US09511142B2
公开(公告)日：2016-12-06
申请号：US14737323
申请日：2015-06-11
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout
IPC分类号： C07F5/02 , A61K31/497 , A61K31/69 , A61K45/06
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20160326189A1
公开(公告)日：2016-11-10
申请号：US15212959
申请日：2016-07-18
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K9/0019 , A61K9/0053 , A61K31/69 , A61K45/06 , C07F5/027 , C07F5/04
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US09422314B2
公开(公告)日：2016-08-23
申请号：US14649527
申请日：2013-12-05
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout
CPC分类号： C07F5/025 , A61K9/0019 , A61K9/0053 , A61K31/69 , A61K45/06 , C07F5/027 , C07F5/04
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20160024121A1
公开(公告)日：2016-01-28
申请号：US14773717
申请日：2014-03-13
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K31/69 , A61K45/06 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/483
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20150361107A1
公开(公告)日：2015-12-17
申请号：US14736921
申请日：2015-06-11
发明人： Robert E. Lee TROUT
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
摘要翻译： 本文描述了调节β-内酰胺酶活性的化合物和组合物。 在一些实施方案中，本文所述的化合物抑制β-内酰胺酶。 在某些实施方案中，本文所述的化合物可用于治疗细菌感染。
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