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公开(公告)号：US11118200B2
公开(公告)日：2021-09-14
申请号：US16628688
申请日：2018-07-05
Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , UNIVERSITE D'EVRY VAL D'ESSONNE (UEVE)
Inventor： Carine Vergne-Vaxelaire , Véronique De Berardinis , Anne Zaparucha
Abstract: The present invention relates to the preparation of amines from aldehydes and ketones by reductive amination with enzymes having a reductive aminase activity on aldehydes and ketones devoid of any carboxyl group gamma of the carbonyl group. The invention also relates to the enzymes per se and their uses in biocatalysis. The enzymes are derived from Mycobacterium smegmatis and vaccae, Cystobacter fuscus, Microbacterium sp. and Aminomonas paucivorans.
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公开(公告)号：US20200239870A1
公开(公告)日：2020-07-30
申请号：US16633768
申请日：2018-07-27
Inventor： David PASTRE , Bénédicte DESFORGES , Alexandre MAUCUER
IPC: C12N15/10 , C12Q1/6806
Abstract: The present invention relates to the field of nucleic acid purification. In particular, it relates to methods and tools for purifying nucleic acids in a sample; which are compatible with high-throughput sequencing and diagnosis. The inventors have shown that nucleic acid binding proteins recruited to polymerized tubulin (i.e. microtubules) could, subsequently, be isolated from cell lysates. Surprisingly, it has now been found that the amount of recovered nucleic acid found in these microtubule pellets increases dramatically in the presence of nucleic acid-trapping proteins comprising a nucleic acid-binding moiety and a polymerized tubulin-binding moiety, by comparison to proteins devoid of the nucleic acid-binding moiety; and that the recovery of the purified nucleic acids was itself particularly efficient. This purification method is particularly amenable to high-throughput sequencing and/or in the context of a diagnosis method for identifying or comparing the amount of nucleic acids in a set of samples.
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公开(公告)号：US20200224225A1
公开(公告)日：2020-07-16
申请号：US16628688
申请日：2018-07-05
Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , UNIVERSITE D'EVRY VAL D'ESSONNE (UEVE)
Inventor： CARINE VERGNE-VAXELAIRE , VÉRONIQUE DE BERARDINIS , ANNE ZAPARUCHA
IPC: C12P13/00
Abstract: The present invention relates to the preparation of amines from aldehydes and ketones by reductive amination with enzymes having a reductive aminase activity on aldehydes and ketones devoid of any carboxyl group gamma of the carbonyl group. The invention also relates to the enzymes per se and their uses in biocatalysis. The enzymes are derived from Mycobacterium smegmatis and vaccae, Cystobacter fuscus, Microbacterium sp. and Aminomonas paucivorans.
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公开(公告)号：US10654838B2
公开(公告)日：2020-05-19
申请号：US15518127
申请日：2015-10-07
Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES , UNIVERSITE D'EVRY VAL D'ESSONNE
Inventor： Marc Peschanski , Sophie Blondel , Xavier Nissan
IPC: C07D409/14 , C07D403/12 , C07D401/14 , C07D405/14 , C07D401/06 , C07D401/02
Abstract: A compound for use in the treatment and/or prevention of diseases or disorders wherein an inhibition of protein prenylation is required, which is alternatively chosen among wherein R1 is 2-pyridyl, 3-pyridyl or 4-pyridyl; R2 represents: and wherein R5 and R6 represent a hydrogen atom or a (C1-4)alkyl group; and R7 represents an arylcarbonyl group, a heteroarylcarbonyl group, a heteroarylacetyl group, a (C1-C4)alkoxy-carbonylmethyl group, a group. Also disclosed are novel compounds of formulae (I) and (II).
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55.发明授权公开(公告)号：US10591486B2
公开(公告)日：2020-03-17
申请号：US15328073
申请日：2015-07-21
Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE D'EVRY—VAL D'ESSONNE
Inventor： David Pastre , Michel Cailleret , Patrick Curmi , Mirela Boca
Abstract: A method for detecting an interaction between one or more protein bait and one or more candidate prey in a eukaryotic cell, comprising the steps of: a) providing an eukaryotic cell expressing (i) one or more protein bait, and (ii) one or more candidate prey, wherein said protein bait comprises a bait moiety and a polymerized-tubulin binding moiety. b) determining the occurence of an interaction between said one or more protein bait and said one or more candidate prey in the eukaryotic cell, wherein said protein bait is bound to polymerized tubulin in the eukaryotic cell, thereby localizing said one or more candidate prey along said polymerized tubulin, thereby detecting said interaction.
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Patent Agency Ranking
公开(公告)号：US20180100144A1
公开(公告)日：2018-04-12
申请号：US15569203
申请日：2016-04-27
Applicant: GENETHON , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE D'EVRY VAL D'ESSONNE
Inventor： Ana Maria BUJ BELLO , Mirella LO SCRUDATO
CPC classification number: C12N15/102 , C12N15/111 , C12N2310/10 , C12N2310/20 , C12N2320/30 , C12Q2521/319
Abstract: The present invention relates to compositions and methods for the treatment of nucleotide repeat expansion disorders such as myotonic dystrophy.
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公开(公告)号：US20240390356A1
公开(公告)日：2024-11-28
申请号：US18695991
申请日：2022-12-20
Applicant: UNIVERSITAT DE VALÈNCIA , CECS , INSERM, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , UNIVERSITE D'EVRY VAL D'ESSONNE , UNIVERSITÁ DEGLI STUDI DI TORINO , FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL CLÍNICO DE LA COMUNIDAD VALENCIANA
Inventor： Piotr Tadeusz KONIECZNY , Rubén Darío ARTERO ALLEPUZ , Camille JANUEL , Cécile MARTINAT , Marina Maria BOIDO , Giovanna MENDUTI
IPC: A61K31/4515 , A61K31/4709 , A61P21/00
Abstract: Haloperidol, or a pharmaceutically acceptable salt, ester or solvate thereof, as well as pharmaceutical compositions comprising the same, for use in methods for preventing and/or treating spinal muscular atrophy, are described.
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公开(公告)号：US20240067942A1
公开(公告)日：2024-02-29
申请号：US18266282
申请日：2021-12-09
Applicant: GENETHON , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE D'EVRY VAL D'ESSONNE , UNIVERSITE PARIS-SACLAY
Inventor： MARIO AMENDOLA , MARINE LAURENT , GIULIA PAVANI
IPC: C12N9/20 , A61P3/00 , C12N5/0789 , C12N15/86
CPC classification number: C12N9/20 , A61P3/00 , C12N5/0647 , C12N15/86 , C12N2710/10041 , C12Y301/01013
Abstract: The present invention relates to variants of lysosomal acid lipase (LAL) and uses thereof.
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公开(公告)号：US20230277686A1
公开(公告)日：2023-09-07
申请号：US18004372
申请日：2021-07-09
Applicant: GENETHON , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCH MEDICALE) , UNIVERSITE D'EVRY-VAL-D'ESSONNE
Inventor： William LOSTAL , Isabelle RICHARD
CPC classification number: A61K48/0058 , C12N15/86 , C12N9/6472 , C12Y304/22054 , C07K14/4708 , C07K14/47 , C07K14/471 , A61P21/00 , C12N2750/14143 , C12N2820/007 , C07K2319/00
Abstract: The present invention concerns a novel short promoter characterized by a high activity in the skeletal muscles and a low activity in the heart. It then constitutes a valuable candidate especially for driving the expression of transgenes encoding proteins useful for the treatment of muscular dystrophies.
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60.发明公开公开(公告)号：US20230242905A1
公开(公告)日：2023-08-03
申请号：US18013339
申请日：2021-07-05
Applicant: Genethon , Institut National de la Santé et de la Recherche Médicale , Universite d'Evry Val d'Essonne
Inventor： Giuseppe Ronzitti , Tiziana Labella
CPC classification number: C12N15/1082 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14145 , C12N2750/14152
Abstract: The invention relates to a method of preparation of a recombinant hybrid adeno-associated virus (AAV) capsid protein with improved tropism and to the recombinant hybrid AAV capsid protein obtainable by the method. The invention relates also to the derived expression vector, modified cell, and hybrid capsid AAV vector particle packaging a gene of interest, and its use in tissue-targeted gene therapy for treating various diseases.
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