公开(公告)号：US4452789A

公开(公告)日：1984-06-05

申请号：US436588

申请日：1982-10-25

申请人： Walter Losel ,  Otto Roos ,  Richard Reichl ,  Franz-Josef Kuhn

发明人： Walter Losel ,  Otto Roos ,  Richard Reichl ,  Franz-Josef Kuhn

IPC分类号： A61K31/47 ,  A61K31/4725 ,  A61P9/00 ,  C07D307/68 ,  C07D405/04 ,  C07D405/14 ,  A61K31/535 ,  C07D413/14

CPC分类号： C07D405/04 ,  C07D307/68 ,  C07D405/14

摘要： Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydroxyl or lower alkoxyR.sub.3 is cyano or --CO--Y;Y is hydroxyl, lower alkoxy, or a primary or secondary, substituted or unsubstituted, aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic amino group;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful for the treatment of circulatory and coronary disorders.

摘要翻译： 其中R 1和R 2可以相同或不同，各自为羟基或低级烷氧基，R 3为氰基或-CO-Y; Y是羟基，低级烷氧基或伯或仲，取代或未取代的脂族，脂环族，芳脂族，芳族或杂环氨基; 和无毒的，药学上可接受的酸加成盐。 化合物以及盐可用于治疗循环系统和冠状动脉疾病。

公开(公告)号：US4004032A

公开(公告)日：1977-01-18

申请号：US652801

申请日：1976-01-27

申请人： Kurt Schromm ,  Ernst-Otto Renth ,  Anton Mentrup ,  Richard Reichl

发明人： Kurt Schromm ,  Ernst-Otto Renth ,  Anton Mentrup ,  Richard Reichl

IPC分类号： C07C45/56 ,  C07C47/55 ,  A61K31/135

CPC分类号： C07C47/55 ,  C07C45/565

摘要： Pharmaceutical dosage unit compositions containing as an active ingredient a racemic or optically active compound of the formula ##STR1## wherein R is --(CH.sub.2).sub.n --CO--C.sub.6 H.sub.5 or --(CH.sub.2).sub.n --CO--CH.sub.3,n is 1 or 2, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as appetite suppressants.

摘要翻译： 含有下式的外消旋或光学活性化合物作为活性成分的药物剂量单位组合物其中R为 - （CH 2）n -CO-C 6 H 5或 - （CH 2）n -CO-CH 3，n为1或2， 或其无毒的药学上可接受的酸加成盐; 以及将其用作食欲抑制剂的方法。

公开(公告)号：US3987047A

公开(公告)日：1976-10-19

申请号：US520965

申请日：1974-11-05

申请人： Gerhart Griss ,  Rudolf Hurnaus ,  Wolfgang Grell ,  Robert Sauter ,  Richard Reichl

发明人： Gerhart Griss ,  Rudolf Hurnaus ,  Wolfgang Grell ,  Robert Sauter ,  Richard Reichl

IPC分类号： C07D471/04 ,  C07D491/14 ,  C07D491/147

CPC分类号： C07D471/04 ,  C07D491/14 ,  Y10S514/96 ,  Y10S514/966

摘要： Compounds of the formula ##SPC1##Wherein ##EQU1## where R.sub.1 is hydrogen, straight or branched aliphatic acyl of 1 to 12 carbon atoms, methoxy-substituted straight or branched aliphatic acyl of 1 to 12 carbon atoms, benzoyl, halo-benzoyl, carbalkoxy of 2 to 7 carbon atoms, carbcycloalkoxy of 4 to 7 carbon atoms, benzyl, methylbenzyl, phenylsulfonyl, halo-phenylsulfonyl, tolylsulfonyl, alkenyl of 2 to 6 carbon atoms, phenyl, trifluoroacetyl, amidino, amido, thioamido, phenoxycarbonyl, benzyloxycarbonyl, methylsulfonyl or--B -- XwhereB is straight or branched alkylene of 1 to 6 carbon atoms, andX is hydrogen, hydroxyl, methoxy, carboxyl, cyano, dimethylaminocarbonyl, morpholino-carbonyl or carbalkoxy of 2 to 6 carbon atoms,R.sub.2 is hydrogen, hydroxyl, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, alkanoyloxy of 1 to 3 carbon atoms, alkoxycarbonyloxy of 2 to 4 carbon atoms, amino, dimethylamino, morpholino or halogen,R.sub.3 is hydrogen, halogen, hydroxyl, carboxyl, straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, alkoxy of 1 to 3 carbon atoms, phenyl-alkoxy of 1 to 3 carbon atoms, carbalkoxy of 2 to 4 carbon atoms -- alkoxy of 1 to 3 carbon atoms, carbalkoxy of 2 to 4 carbon atoms, hydroxymethyl, phenyl, phenoxy, amino, pyrrolidino or morpholino,R.sub.4, r.sub.5 and R.sub.6, which may be identical to or different from each other, are each hydrogen, halogen, methyl, hydroxyl, methoxy, cyano, amino, nitro, trifluoromethyl, carboxyl, acetyl or carbalkoxy of 2 to 4 carbon atoms, or any two of R.sub.4, R.sub.5 and R.sub.6 together are methylenedioxy, andX.sub.1 and X.sub.2 are hydrogen or together form a double bond,6-N-oxides thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anoretics.