公开(公告)号：US06823039B2

公开(公告)日：2004-11-23

申请号：US10176275

申请日：2002-06-20

Applicant: Martin Hoheisel ,  Hartmut Sklebitz

Inventor： Martin Hoheisel ,  Hartmut Sklebitz

IPC: A61B603

CPC classification number: G01N23/046 ,  A61B6/032 ,  A61B6/4266 ,  A61B6/4417 ,  A61B6/4452 ,  A61B6/5235 ,  G01N2223/419 ,  G01N2223/612

Abstract: A computed tomography apparatus has a gantry with an X-ray source and an x-ray detector, and at least one further, curved solid-state radiation detector that is movable into and out of the beam path of the x-ray source is provided in the gantry.

Abstract translation: 计算机断层摄影装置具有具有X射线源和X射线检测器的台架，并且提供可进入和离开x射线源的光束路径的至少一个另外的弯曲固态放射线检测器 在龙门架

公开(公告)号：US08977342B2

公开(公告)日：2015-03-10

申请号：US12313567

申请日：2008-11-21

Applicant: Martin Hoheisel

Inventor： Martin Hoheisel

IPC: A61B5/05 ,  A61B19/00 ,  A61B17/00

CPC classification number: A61B19/5244 ,  A61B34/20 ,  A61B90/06 ,  A61B2017/00694 ,  A61B2034/2048 ,  A61B2034/2051 ,  A61B2090/064 ,  A61B2090/0818 ,  A61B2090/364

Abstract: The invention relates to a device for a medical intervention in or on moving tissue of a living being, said device having a medical instrument provided for the intervention, a position detection system by means of which the position of the medical instrument in the body of the living being can be determined, and at least one acceleration sensor for recording at least one movement of the instrument caused by the moving tissue. The invention also relates to a medical instrument for a medical intervention in or on moving tissue of a living being, said medical instrument having at least one acceleration sensor and a sensor of a position detection system, as well as to an operating method for the device.

Abstract translation: 本发明涉及一种用于在活体内或移动组织上进行医疗干预的装置，所述装置具有用于干预的医疗器具，位置检测系统，通过该位置检测系统，医疗器械在身体中的位置 可以确定生物体，以及至少一个加速度传感器，用于记录由移动组织引起的仪器的至少一个运动。 本发明还涉及一种医疗器械，用于医疗介入在活体的移动组织中或其上，所述医疗器具具有至少一个加速度传感器和位置检测系统的传感器，以及该装置的操作方法 。

公开(公告)号：US08374309B2

公开(公告)日：2013-02-12

申请号：US12686404

申请日：2010-01-13

Applicant: Tilman Donath ,  Martin Hoheisel ,  Christian David ,  Eckhard Hempel ,  Franz Pfeiffer ,  Stefan Popescu

Inventor： Tilman Donath ,  Martin Hoheisel ,  Christian David ,  Eckhard Hempel ,  Franz Pfeiffer ,  Stefan Popescu

IPC: H05G1/64 ,  A61B6/03 ,  G01N23/083 ,  G21K1/00 ,  G21K3/00

CPC classification number: G03B42/02 ,  A61B6/032 ,  A61B6/4291 ,  A61B6/484

Abstract: An arrangement and a method are disclosed for projective and/or tomographic phase-contrast imaging using X-ray radiation. In at least one embodiment, one or more phase grids is/are arranged in the beam path such that during a rotation of the at least one X-ray source, the examination object is scanned with different spatial orientations of the grid lines relative to the examination object such that the complete refraction angle, and hence the complete phase shift gradient, can be determined for each X-ray beam from the two scans with differently oriented phase grids in order to be able to show the phase shift of an examination object in terms of projections or in a tomographic image.

Abstract translation: 公开了用于使用X射线辐射的投影和/或断层扫描相位对比成像的布置和方法。 在至少一个实施例中，在所述光束路径中布置一个或多个相位栅格，使得在所述至少一个X射线源的旋转期间，所述检查对象以相对于所述栅格线的不同的空间取向被扫描 可以从具有不同定向相位网格的两次扫描中确定每个X射线束的完整折射角，从而完整的相移梯度，以便能够显示检查对象的相移 投影术语或断层图像。

公开(公告)号：US08233967B2

公开(公告)日：2012-07-31

申请号：US12222505

申请日：2008-08-11

Applicant: Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

Inventor： Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

IPC: G01N23/02

CPC classification number: A61B6/12 ,  A61B6/4291 ,  A61B6/484 ,  A61F2/82 ,  A61F2250/0032 ,  A61F2250/0098 ,  A61L27/50 ,  A61L31/18 ,  G21K2207/005

Abstract: A method is disclosed for marking and visualizing an implant by use of an x-ray phase-contrast tomography examination. Further, an implant is also disclosed. In at least one embodiment, implants are used with specific characteristics which are as unambiguous as possible with regard to the phase shift generated by the implants in a phase-contrast tomography examination. In at least one embodiment, these specific characteristics can include the typical self-generated specific phase shift, typical differences in the specific phase-shift values, or typical spatial structures of materials with well-defined phase-shift values.

Abstract translation: 公开了一种通过使用X射线相位层析成像检查对植入物进行标记和可视化的方法。 此外，还公开了一种植入物。 在至少一个实施例中，使用具有特定特征的植入物，其相对于相位层析成像检查中由植入物产生的相移尽可能不含糊。 在至少一个实施例中，这些特定特征可以包括典型的自发特定相移，特定相移值中的典型差异或具有明确定义的相移值的材料的典型空间结构。

公开(公告)号：US07983381B2

公开(公告)日：2011-07-19

申请号：US12570178

申请日：2009-09-30

Applicant: Christian David ,  Tilman Donath ,  Eckhard Hempel ,  Martin Hoheisel ,  Franz Pfeiffer ,  Stefan Popescu

Inventor： Christian David ,  Tilman Donath ,  Eckhard Hempel ,  Martin Hoheisel ,  Franz Pfeiffer ,  Stefan Popescu

IPC: H05G1/60 ,  G01N23/04

CPC classification number: G01N23/046 ,  A61B6/032 ,  A61B6/06 ,  A61B6/4291 ,  A61B6/483 ,  A61B6/484 ,  G01N2223/419 ,  G01N2223/612 ,  G21K2207/005

Abstract: An x-ray CT system for x-ray phase contrast and/or x-ray dark field imaging has a grating interferometer that has a first grating structure that has a number of band-shaped x-ray emission maxima and minima arranged in parallel, the maxima and minima exhibiting a first grating period, a second band-shaped grating structure that produces, as a phase grating, a partial phase offset of x-ray radiation passing therethrough and that exhibits a second grating period, a third band-shaped grating structure with a third grating period with which relative phase shifts of adjacent x-rays and/or their scatter components are detected, and a device for value-based determination of the phase between adjacent x-rays and/or for value-based determination of the spatial intensity curve per detector element perpendicular to the bands of the grating structures. The third grating structure has a grating period that is larger by a factor of 2 to 5 than the grating period of the first grating structure.

Abstract translation: 用于x射线相位对比和/或x射线暗场成像的X射线CT系统具有光栅干涉仪，该光栅干涉仪具有第一光栅结构，该第一光栅结构具有平行布置的多个带状x射线发射最大值和最小值， 显示第一光栅周期的最大值和最小值;第二带状光栅结构，其产生通过其中的X射线辐射的部分相位偏移作为相位光栅，并且具有第二光栅周期;第三带状光栅 具有第三光栅周期的结构，利用该第三光栅周期检测相邻x射线和/或其散射分量的相对相移，以及用于基于值的确定相邻x射线之间的相位和/或基于值的确定的装置 每个检测器元件垂直于光栅结构的带的空间强度曲线。 第三光栅结构具有比第一光栅结构的光栅周期大2至5倍的光栅周期。

公开(公告)号：US20090240154A1

公开(公告)日：2009-09-24

申请号：US12476294

申请日：2009-06-02

Applicant: Oliver Meissner ,  Martin Ostermeier ,  Martin Hoheisel

Inventor： Oliver Meissner ,  Martin Ostermeier ,  Martin Hoheisel

IPC: A61N5/06 ,  A61B6/00

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/0084 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0609

Abstract: In a catheter device and a method for in vivo activation of a photosensitizing drug in a vessel, endovascular tissue, and/or intraluminal tissue, a catheter carrying both an optical coherence tomography (OCT) lens, from which OCT imaging light is emitted, and a photodynamic therapy (PDT) lens from which photosensitizing drug-activating light is emitted, is inserted into a vessel containing a lesion to be treated. A photosensitizing drug is caused to be placed in the vessel as well, such as in the form of a coating on a stent or a coating on an exterior of a balloon carried by the catheter. Light is emitted from the PDT lens to activate the photosensitizing drug while light is simultaneously emitted from the OCT lens to obtain an OCT image to monitor the drug activation.

Abstract translation: 在导管装置和用于体内活化容器，血管内组织和/或管腔内组织中的光敏药物的方法中，携带OCT成像光的光学相干断层摄影（OCT）透镜的导管以及 将光敏感药物激活光发射的光动力疗法（PDT）镜片插入含有待治疗病变的容器中。 导致光敏药物也被放置在容器中，例如以支架的形式或由导管承载的球囊的外部上的涂层的形式。 光从PDT透镜发射以激活光敏药物，同时从OCT镜片同时发出光，以获得OCT图像以监测药物激活。

公开(公告)号：US20090149740A1

公开(公告)日：2009-06-11

申请号：US12313567

申请日：2008-11-21

Applicant: Martin Hoheisel

Inventor： Martin Hoheisel

IPC: A61B5/05

CPC classification number: A61B19/5244 ,  A61B34/20 ,  A61B90/06 ,  A61B2017/00694 ,  A61B2034/2048 ,  A61B2034/2051 ,  A61B2090/064 ,  A61B2090/0818 ,  A61B2090/364

Abstract: The invention relates to a device for a medical intervention in or on moving tissue of a living being, said device having a medical instrument provided for the intervention, a position detection system by means of which the position of the medical instrument in the body of the living being can be determined, and at least one acceleration sensor for recording at least one movement of the instrument caused by the moving tissue. The invention also relates to a medical instrument for a medical intervention in or on moving tissue of a living being, said medical instrument having at least one acceleration sensor and a sensor of a position detection system, as well as to an operating method for the device.

Abstract translation: 本发明涉及一种用于在活体内或移动组织上进行医疗干预的装置，所述装置具有用于干预的医疗器具，位置检测系统，通过该位置检测系统，医疗器械在身体中的位置 可以确定生物体，以及至少一个加速度传感器，用于记录由移动组织引起的仪器的至少一个运动。 本发明还涉及一种医疗器械，用于医疗介入在活体的移动组织中或其上，所述医疗器具具有至少一个加速度传感器和位置检测系统的传感器，以及该装置的操作方法 。

公开(公告)号：US20090074139A1

公开(公告)日：2009-03-19

申请号：US12222077

申请日：2008-08-01

Applicant: Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

Inventor： Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

IPC: G01N23/04 ,  A61B6/03

CPC classification number: A61B6/032 ,  A61B5/14532 ,  A61B6/484 ,  G21K2207/005

Abstract: A method and an x-ray system are disclosed for detecting and localizing a metabolic marker. In at least one embodiment, the method includes creating at least one absorption x-ray view of a patient or of a first region of a patient; creating at least one phase-contrast x-ray view of the patient or of a second region of the patient, with a quasi-coherent x-ray radiation being generated for the phase-contrast measurement with the aid of an x-ray grating arranged between the x-ray source and the patient, and the spatially dependent phase shift of the x-ray radiation in the patient being made visible with the aid of at least one grating between the patient and a detector; superposing the at least one absorption x-ray view and the at least one phase-contrast x-ray view; wherein orientation based on anatomical features is carried out with the aid of the at least one absorption x-ray view, and a spatial distribution of the metabolic marker present in the body of the patient is determined by the at least one phase-contrast x-ray view.

Abstract translation: 公开了用于检测和定位代谢标记物的方法和x射线系统。 在至少一个实施例中，该方法包括创建患者或患者的第一区域的至少一个吸收x射线视图; 产生患者或患者的第二区域的至少一个相差x射线图，其中准相干X射线辐射是借助于布置在所述X射线光栅上的相位对比度测量来产生的 在x射线源和患者之间，借助于患者和检测器之间的至少一个光栅使患者中的x射线辐射的空间相关相移变得可见; 叠加所述至少一个吸收x射线视图和所述至少一个相差x射线视图; 其中基于解剖特征的取向借助于所述至少一个吸收x射线视图进行，并且存在于患者体内的代谢标记的空间分布由所述至少一个相位对比度x射线确定， ray视图。

公开(公告)号：US20090052614A1

公开(公告)日：2009-02-26

申请号：US12222505

申请日：2008-08-11

Applicant: Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

Inventor： Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

IPC: A61B6/00 ,  A61B5/05

CPC classification number: A61B6/12 ,  A61B6/4291 ,  A61B6/484 ,  A61F2/82 ,  A61F2250/0032 ,  A61F2250/0098 ,  A61L27/50 ,  A61L31/18 ,  G21K2207/005

Abstract: A method is disclosed for marking and visualizing an implant by use of an x-ray phase-contrast tomography examination. Further, an implant is also disclosed. In at least one embodiment, implants are used with specific characteristics which are as unambiguous as possible with regard to the phase shift generated by the implants in a phase-contrast tomography examination. In at least one embodiment, these specific characteristics can include the typical self-generated specific phase shift, typical differences in the specific phase-shift values, or typical spatial structures of materials with well-defined phase-shift values.

Abstract translation: 公开了一种通过使用X射线相位层析成像检查对植入物进行标记和可视化的方法。 此外，还公开了一种植入物。 在至少一个实施例中，使用具有特定特征的植入物，其相对于相位层析成像检查中由植入物产生的相移尽可能不含糊。 在至少一个实施例中，这些特定特征可以包括典型的自发特定相移，特定相移值中的典型差异或具有明确定义的相移值的材料的典型空间结构。

公开(公告)号：US20090052611A1

公开(公告)日：2009-02-26

申请号：US12222349

申请日：2008-08-07

Applicant: Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

Inventor： Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

IPC: A61B6/00

CPC classification number: A61B6/032 ,  A61B6/037 ,  A61B6/484 ,  A61B6/503 ,  A61B6/507

Abstract: A method and an x-ray computed tomography system are disclosed for visualizing at least two different types of cardiac tissue, such as normally perfused tissue, hypoperfused tissue and scarred tissue. In at least one embodiment, this is done by use of an imaging tomographic recording technique with the aid of x-ray radiation, wherein at least one cardiac region of a patient is scanned by x-ray radiation which passes through a first grating for the passing-through x-ray radiation, designed as an absorption grating, prior to reaching the patient, and at least the locally caused phase-shifts of the x-ray radiation in the cardiac region are also made detectable by using a second grating for the passing-through x-ray radiation, designed as a phase grating, downstream of the patient in the emission direction, and the spatial distribution of these shifts is measured and reconstructed, wherein an average specific phase-shift value is assigned to each spatial unit, wherein each of the abovementioned tissue types are assigned to a region of a typical specific phase-shift value and at least one region assigned to a tissue type is optically highlighted in a view of the cardiac region.

Abstract translation: 公开了一种方法和x射线计算机断层摄影系统，用于可视化至少两种不同类型的心脏组织，例如通常灌注的组织，低灌注组织和瘢痕组织。 在至少一个实施例中，这通过使用借助于X射线辐射的成像断层摄影记录技术来完成，其中患者的至少一个心脏区域被x射线辐射扫描，X射线辐射通过第一光栅 在到达患者之前设计为吸收光栅的穿透X射线辐射以及至少在心脏区域中的x射线辐射的局部引起的相移也可以通过使用第二光栅来检测 测量并重构这些偏移的空间分布，其中平均特定相移值被分配给每个空间单元，其中， 其中上述组织类型中的每一种被分配给典型的特定相移值的区域，并且指定为组织类型的至少一个区域在心脏区域的视图中被光学突出显示。