公开(公告)号：US20250147092A1

公开(公告)日：2025-05-08

申请号：US18837533

申请日：2023-02-10

Applicant: Monash University

Inventor： Reza Razzaghi ,  David Flynn ,  Lachlan Andrew

IPC: G01R31/08

Abstract: A method for estimating fault location in an electrical power line system (PLS) is provided. The method includes receiving an observed signal caused by a real fault in the PLS. The observed signal is measured at a real observation point in the PLS. The real fault has occurred at one of two or more real locations in the PLS; accessing a library representing model signals between model guessed fault locations and a model observation point in a network model of the PLS; selecting a model GFL by: (i) calculating metrics for the model signals by processing the model signals with the observed signal, and/or (ii) selecting the model GFL corresponding to a highest calculated metric; estimating a fault location of real locations in the PLS based on a corresponding location of the selected model GFL; and sending the estimated fault location to an external management system.

公开(公告)号：US20250011388A1

公开(公告)日：2025-01-09

申请号：US18705274

申请日：2022-10-28

Applicant: MONASH UNIVERSITY ,  THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH

Inventor： Ross Alexander Dickins ,  Ethan Paul Oxley ,  Katharine Jennifer Goodall ,  Maximilian Meredith Garwood ,  Nadia Jean Kershaw

IPC: C07K14/705 ,  A61K38/00 ,  A61P35/00

Abstract: The present application relates to CTLA4 fusion proteins, compositions comprising the same, and uses thereof, wherein the CTLA4 fusion proteins do not displace cis-bound PDL1 from B7 upon binding.

公开(公告)号：US12186361B2

公开(公告)日：2025-01-07

申请号：US17348023

申请日：2021-06-15

Applicant: Monash University

Inventor： Michelle McIntosh ,  David Morton ,  Tomas Sou ,  Livesey Olerile ,  Richard Prankerd

IPC: A61K38/00 ,  A61K9/00 ,  A61K9/16 ,  A61K38/095 ,  C07K7/16

Abstract: This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.

公开(公告)号：US20250006821A1

公开(公告)日：2025-01-02

申请号：US18707515

申请日：2022-11-10

Applicant: Monash University

Inventor： Michael Sears Fuhrer

IPC: H01L29/66 ,  H01L29/16 ,  H01L29/24 ,  H01L29/51

Abstract: Disclosed herein is A structure comprising: a top gate electrode and a bottom gate electrode, a channel layer formed from a channel material with a band gap modulable by electric field, the channel layer being electrically insulated from the top gate electrode and the bottom gate electrode and being located adjacent to at least one layer of a negative capacitance material.

公开(公告)号：US20240278194A1

公开(公告)日：2024-08-22

申请号：US18569729

申请日：2022-06-15

Applicant: Monash University

Inventor： Mainak MAJUMDER ,  Abozar AKBARIVAKILABADI ,  Sally EL MERAGAWI ,  Petar JOVANOVIC

IPC: B01D71/06 ,  B01D61/02 ,  B01D67/00 ,  B01D69/02 ,  C02F1/44

CPC classification number: B01D71/06 ,  B01D61/027 ,  B01D67/0079 ,  B01D69/02 ,  C02F1/442 ,  B01D2323/345 ,  B01D2325/04 ,  B01D2325/20

Abstract: Disclosed herein is a phenolic-graphene oxide composition comprising phenolic-graphene oxide having a carbon to oxygen (C:O) ratio of 2.1 or greater and 5 or less.

公开(公告)号：US11976343B2

公开(公告)日：2024-05-07

申请号：US18360904

申请日：2023-07-28

Applicant: MONASH UNIVERSITY

Inventor： Paul Rometsch ,  Xinhua Wu ,  Qingbo Jia

IPC: C22C1/04 ,  B22F3/24 ,  B22F10/28 ,  B22F10/64 ,  B22F12/20 ,  B33Y70/00 ,  C22C21/00 ,  C22F1/00 ,  C22F1/04

CPC classification number: C22C1/0416 ,  B22F3/24 ,  B22F10/28 ,  B22F10/64 ,  B22F12/20 ,  B33Y70/00 ,  C22C21/00 ,  C22F1/002 ,  C22F1/04 ,  B22F2003/248 ,  B22F2998/10 ,  B22F10/28 ,  B22F3/1028 ,  B22F2003/248

Abstract: An aluminium based alloy, and a method for production of components by additive manufacturing (AM) or other rapid solidification process with the alloy, is based on the alloy having a composition with from 2.01 wt % to 15.0 wt % manganese, from 0.3 wt % to 2.0 wt % scandium, with a balance apart from minor alloy elements and incidental impurities of aluminium.

公开(公告)号：US11975073B2

公开(公告)日：2024-05-07

申请号：US18341519

申请日：2023-06-26

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth Bonner ,  Rishab R. Shyam ,  Jamie Simpson ,  Christopher John Porter ,  Natalie Trevaskis ,  Tim Quach ,  Sifei Han ,  Luojuan Hu

IPC: A61K47/55 ,  A61K9/00 ,  A61K31/573 ,  A61K47/54

CPC classification number: A61K47/55 ,  A61K9/0053 ,  A61K31/573 ,  A61K47/542

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：US20240117031A1

公开(公告)日：2024-04-11

申请号：US18240347

申请日：2023-08-30

Applicant: MONASH UNIVERSITY

Inventor： Justin HAMILTON ,  Mark SLEEMAN

IPC: C07K16/28 ,  A61K47/68 ,  A61P7/02

CPC classification number: C07K16/28 ,  A61K47/6849 ,  A61P7/02 ,  C07K2317/34 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is directed to human protease activated receptor 4 (PAR4) binding proteins (e.g. antibodies). In particular, anti-PAR4 binding proteins which are antagonists of human PAR4, as well as methods and uses thereof.

公开(公告)号：US20240084308A1

公开(公告)日：2024-03-14

申请号：US18495512

申请日：2023-10-26

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: C12N15/113 ,  A61K31/351 ,  A61K31/395 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12

CPC classification number: C12N15/1137 ,  A61K31/351 ,  A61K31/395 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12 ,  C12N2310/14

Abstract: The present invention relates to compositions, methods and kits for the treatment of fibrosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of cardiac fibrosis. The invention provides a method of treating fibrosis in an individual comprising administering an inhibitor of insulin-regulated aminopeptidase (IRAP), thereby treating fibrosis.

公开(公告)号：US11883497B2

公开(公告)日：2024-01-30

申请号：US16642794

申请日：2018-08-29

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth Bonner ,  Ketki Karanam ,  James T. Mutamba ,  Rishab R. Shyam ,  Jamie Simpson ,  Sifei Han ,  Luojuan Hu ,  Christopher John Hamilton Porter ,  Tim Quach ,  Natalie Trevaskis

IPC: A61K45/06 ,  A61K47/54

CPC classification number: A61K47/543 ,  A61K45/06

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.