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公开(公告)号：US12030945B2
公开(公告)日：2024-07-09
申请号：US18494454
申请日：2023-10-25
Applicant: Seismic Therapeutic, Inc.
Inventor： Yen-Lin Chen , Ryan Peckner , Nathan Higginson-Scott , Daniela Cipolletta , Yanfeng Zhou , Kevin Lewis Otipoby , Jyothsna Visweswaraiah
IPC: C07K16/28
CPC classification number: C07K16/2818 , C07K16/2803 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/75
Abstract: Embodiments provided herein, provide for variant IgG Fc polypeptides, dimeric molecules, pharmaceutical compositions, and methods that can be used to target at cells to modulate the activity of the same to treat disorders, such as autoimmune disorders or cancers.
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公开(公告)号：US12030923B2
公开(公告)日：2024-07-09
申请号：US17105358
申请日：2020-11-25
Applicant: Bristol-Myers Squibb Company
Inventor： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC: A61K39/395 , A61K38/19 , C07K14/705 , C07K16/28 , A61K38/00 , B01D15/38
CPC classification number: C07K14/70521 , A61K38/195 , C07K16/2818 , A61K38/00 , B01D15/3804 , C07K2317/73 , C07K2317/76 , C07K2319/30 , B01D15/3804 , B01D15/363 , B01D15/327 , G01N30/461 , A61K38/195 , A61K2300/00
Abstract: The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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公开(公告)号：US20240218067A1
公开(公告)日：2024-07-04
申请号：US18558112
申请日：2022-04-29
Applicant: ONCOC4, INC. , UNIVERSITY OF MARYLAND, BALTIMORE
Inventor： Yang LIU , Pan ZHENG , Martin DEVENPORT , Mingyue LIU
CPC classification number: C07K16/2818 , A61P35/00 , A61K2039/507 , C07K2317/24 , C07K2317/565
Abstract: The disclosure relates to anti-Siglec-10 antibodies and the use of such antibodies in cancer therapy.
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公开(公告)号：US20240218030A1
公开(公告)日：2024-07-04
申请号：US18289179
申请日：2022-05-03
Applicant: CELLEMEDY CO., LTD
Inventor： Jee Won LEE , Bo Ram LEE
CPC classification number: C07K14/47 , C07K16/084 , C07K16/2803 , C07K16/2806 , C07K16/2809 , C07K16/2818 , C07K16/2821 , C07K16/2827 , C07K16/2851 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K16/30 , C07K16/3007 , C07K16/3069 , C07K16/3084 , C07K16/3092 , C07K16/32 , C07K16/40 , C07K2319/30
Abstract: A ferritin protein is mutated to have a foreign peptide fused to the outer surface thereof so that a binding force to a human transferrin receptor is reduced. The peptide can exhibit activities of various foreign peptides. The foreign peptide is a pharmacologically active peptide, and the foreign peptide may include a ligand or a fragment thereof, a receptor or a fragment thereof, an antibody or a fragment thereof including an antigen binding region (CDR), which are capable of binding to an immune checkpoint molecule; or a disease antigen epitope.
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公开(公告)号：US20240216391A1
公开(公告)日：2024-07-04
申请号：US18437859
申请日：2024-02-09
Applicant: GEORGETOWN UNIVERSITY
Inventor： Jill P. SMITH , Louis WEINER , Sandra JABLONSKI , Sandeep NADELLA , Shangzi WANG
IPC: A61K31/5513 , A61K31/198 , A61P35/00 , C07K16/28
CPC classification number: A61K31/5513 , A61K31/198 , A61P35/00 , C07K16/2818
Abstract: Provided herein are methods for treating fibrosis (e.g. pancreatic fibrosis) in a subject. Some methods comprise administering to a subject having pancreatic fibrosis an effective amount of a CCK receptor inhibitor.
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Patent Agency Ranking
公开(公告)号：US20240216388A1
公开(公告)日：2024-07-04
申请号：US18609709
申请日：2024-03-19
Applicant: INSTITUT CURIE , INSERM
Inventor： Sebastian AMIGORENA , Eliane PIAGGIO , Leticia NIBORSKI
IPC: A61K31/546 , A61K38/00 , A61K39/00 , A61K45/06 , A61P35/02 , C07K16/28 , C12N9/10 , C12N15/113 , G01N33/50
CPC classification number: A61K31/546 , A61P35/02 , C07K16/2818 , C07K16/2827 , C12N15/113 , G01N33/5008 , A61K38/00 , A61K2039/505 , A61K45/06 , C07K2317/73 , C07K2317/76 , C12N9/1007 , C12N2310/12 , C12N2310/14 , C12N2310/531
Abstract: The present invention relates to an inhibitor of H3K9 histone methyl transferase SUV39H1 for use in combination with at least one immune checkpoint modulator in the treatment of cancer.
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公开(公告)号：US20240209061A1
公开(公告)日：2024-06-27
申请号：US17908822
申请日：2021-03-05
Applicant: Pfizer Inc.
Inventor： Eric Matthew Bennett , Christina Hwei-Lin Eng , Laura Lin Lohse , Lidia Mosyak , Jeremy Shawn Myers , Mohosin Sarkar , Hayretin Rafet Yumerefendi
IPC: C07K14/705 , A61K31/5025 , A61K39/395 , A61P35/00 , C07K16/28
CPC classification number: C07K14/70532 , A61K31/5025 , A61K39/3955 , A61P35/00 , C07K16/2818 , C07K2317/94 , C07K2319/30
Abstract: The present invention provides for CD80-Fc fusion proteins that have therapeutic and diagnostic use, and methods for making thereof. The present invention further relates to variant CD80 polypeptides. The present invention also provides for CD80-Fc fusion proteins for use in the treatment of cancer.
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公开(公告)号：US20240207381A1
公开(公告)日：2024-06-27
申请号：US18557655
申请日：2022-04-27
Applicant: BIOVAXYS, INC.
Inventor： David Berd
CPC classification number: A61K39/0011 , C07K16/2818 , A61K2039/507 , A61K2039/5152 , A61K2039/545 , A61K2039/6012 , A61K2039/892
Abstract: In some embodiments. methods of treating cervical cancer, including cervical cancers that are resistant to immune checkpoint inhibitor therapy. and cervical cancers that do not respond to immune checkpoint inhibitor therapy or have acquired resistance to immune checkpoint inhibitor therapy are disclosed.
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公开(公告)号：US20240190963A1
公开(公告)日：2024-06-13
申请号：US18468097
申请日：2023-09-15
Applicant: Bristol-Myers Squibb Company
Inventor： Prabhu Seshaiyer Bhagavatheeswaran , Nicholas Allan John Botwood , Han Chang , Yali Fu , William J. Geese , George A. Green, IV , Diane Healey , Sabine Maier , Faith E. Nathan , Abderrahim Oukessou , Giovanni Selvaggi , Joseph Daniel Szustakowski
CPC classification number: C07K16/2818 , A61P35/00 , C07K16/2827 , C07K16/30 , A61K2039/507 , A61K2039/545 , C07K2317/76
Abstract: The disclosure provides a method for treating a subject afflicted with a tumor derived from a non-small cell lung cancer (NSCLC) comprising administering to the subject a therapeutically effective amount of (a) an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof and (b) an anti-CTLA-4 antibody or an antigen binding portion thereof, wherein the tumor has a high tumor mutation burden (TMB) status. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.
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公开(公告)号：US20240182574A1
公开(公告)日：2024-06-06
申请号：US18423752
申请日：2024-01-26
Applicant: Georgiamune Inc.
Inventor： Mikayel MKRTICHYAN , Samir KHLEIF
CPC classification number: C07K16/2818 , A61K9/0019 , A61P35/00 , A61K2039/505 , C07K2317/565 , C07K2317/70
Abstract: Antibodies and antigen-binding fragments thereof that immunospecifically bind to PD-1, such as human or mouse PD-1, and are agonists of PD-1 and can induce or promote an immune response that activates immune cell proliferation or activity. Unlike the majority of known anti-PD-1 and anti-PD-L1 antibodies, which reduce the suppression of PD-1 function by e.g., PD-L1 by physically blocking the interaction between PD-1 and an inactivating ligand, although not to be bound by theory, the disclosed antibodies and antigen-binding fragments thereof are currently best understood to immunospecifically bind to an epitope of PD-1 whereby PD-1 is activated directly. Methods for the treatment of cancer comprising administration of the antibodies or antigen-binding fragments to a subject in need thereof. Polynucleotides encoding the antibodies or antigen-binding fragments. Host cells comprising the polynucleotides.
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