公开(公告)号：US20240139549A1

公开(公告)日：2024-05-02

申请号：US18407321

申请日：2024-01-08

申请人： SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.

发明人： Feichao FU ,  Xing XU ,  Zhou XUE ,  Johannes STAHL

IPC分类号： A61N5/10

CPC分类号： A61N5/1077 ,  A61N5/1044 ,  A61N5/1071 ,  A61N2005/1074 ,  A61N2005/1089

摘要： A method may include identifying a time window of a procedure. The method may also include obtaining operational information of the time window. The operational information may include a limit of pulse repetition frequency (PRF) acceleration and a plurality of preliminary radio frequency (RF) PRFs. The method may also include determining a plurality of updated RF PRFs by updating the plurality of preliminary RF PRFs. A rate of variation between any two adjacent updated RF PRFs may be less than or equal to the limit of PRF acceleration. The method may also include causing an RF source to generate electromagnetic waves at the plurality of updated RF PRFs in the time window.

公开(公告)号：US11865370B2

公开(公告)日：2024-01-09

申请号：US17305516

申请日：2021-07-09

申请人： SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.

发明人： Feichao Fu ,  Xing Xu ,  Zhou Xue ,  Johannes Stahl

IPC分类号： A61N5/10

CPC分类号： A61N5/1077 ,  A61N5/1044 ,  A61N5/1071 ,  A61N2005/1074 ,  A61N2005/1089

摘要： A method may include identifying a time window of a procedure. The method may also include obtaining operational information of the time window. The operational information may include a limit of pulse repetition frequency (PRF) acceleration and a plurality of preliminary radio frequency (RF) PRFs. The method may also include determining a plurality of updated RF PRFs by updating the plurality of preliminary RF PRFs. A rate of variation between any two adjacent updated RF PRFs may be less than or equal to the limit of PRF acceleration. The method may also include causing an RF source to generate electromagnetic waves at the plurality of updated RF PRFs in the time window.

公开(公告)号：US10070831B2

公开(公告)日：2018-09-11

申请号：US15182507

申请日：2016-06-14

申请人： James P. Bennett ,  Stephen L. Spotts ,  W. Davis Lee ,  Susan L. Michaud

发明人： James P. Bennett ,  Stephen L. Spotts ,  W. Davis Lee ,  Susan L. Michaud

IPC分类号： A61B6/00 ,  A61B6/03 ,  A61N5/10 ,  G21K5/04 ,  G21K1/08

CPC分类号： A61B6/4085 ,  A61B6/032 ,  A61B6/4014 ,  A61B6/4258 ,  A61B6/487 ,  A61B6/5205 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1082 ,  A61N2005/105 ,  A61N2005/1054 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/08 ,  G21K5/04

摘要： The invention comprises a positively charged particle based cancer therapy system integrated with at least one off-axis imaging system, where elements of the off-axis imaging system and the cancer therapy system are co-positioned/co-rotated with a gantry. The imaging apparatus optionally functions with a tomography system using the positively charged particles of the cancer therapy system for enhanced patient/tumor imaging at and/or prior to a time of treatment.

公开(公告)号：US20180093111A1

公开(公告)日：2018-04-05

申请号：US15282884

申请日：2016-09-30

申请人： Varian Medical Systems Particle Therapy GmbH

发明人： Markus BACH

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61N5/103 ,  A61N5/1044 ,  A61N5/1049 ,  A61N5/1081 ,  A61N2005/1087

摘要： Interference of dose application in scanned ion beam therapy and organ motion, also called interplay effect, may lead to dose deviations at target volumes. Current repainting methods are susceptible to artefacts due to a predominant scanning direction, ranging from fringed field edges to under and overdosed regions (hot and cold spots). To overcome the difficulties inherent in the repainting techniques of conventional proton therapy systems, new random repainting techniques are described herein for mitigating the under-dose and/or over-dose pattern inherent in existing repainting techniques using a random repainting approach that randomly selects spot locations within the target area.

公开(公告)号：US09782140B2

公开(公告)日：2017-10-10

申请号：US15257686

申请日：2016-09-06

申请人： Susan L. Michaud ,  Daniel J. Raymond ,  W. Davis Lee

发明人： Susan L. Michaud ,  Daniel J. Raymond ,  W. Davis Lee

IPC分类号： A61N5/00 ,  A61B6/00 ,  A61N5/10 ,  A61B6/03 ,  G21K1/08 ,  G21K5/04 ,  A61B6/04

CPC分类号： A61B6/5205 ,  A61B6/032 ,  A61B6/0457 ,  A61B6/4092 ,  A61B6/4258 ,  A61B6/4266 ,  A61B6/50 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1054 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/08 ,  G21K1/10 ,  G21K5/04

摘要： The invention comprises a method and apparatus for imaging and treating a tumor of a patient using positively charged particles and X-rays. A mounting rail, supporting a scintillation detection system element and an X-ray detection system element, is alternatingly extended/retracted to position the required detection system element opposite a patient tumor position from an exit nozzle of a beam transport system connected to an accelerator of the positively charged particles, where the positively charged particles are alternatingly used to treat the tumor via irradiation. The mounting rail optionally rotates with rotation of the exit nozzle about the patient, such as with rotation of a support gantry.

公开(公告)号：US20170056688A1

公开(公告)日：2017-03-02

申请号：US15348625

申请日：2016-11-10

申请人： Scott Penfold ,  W. Davis Lee ,  Mark R. Amato

发明人： Scott Penfold ,  W. Davis Lee ,  Mark R. Amato

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61B6/032 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1037 ,  A61N5/1044 ,  A61N5/1049 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1054 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/08 ,  G21K5/04

摘要： The invention comprises a method and apparatus for probing a tumor of a patient using positively charged particles, comprising the steps of: (1) sequentially delivering sets of varied and known positively charged particles to a patient; (2) after transmission through the patient, sequentially detecting a residual energy of each of the sets of positively charged particles; and (3) determining a water equivalent thickness of a probed path of the patient using a plot of the detector response as a function of residual energy that is fit with a curve. The analyzer relates a half maximum of the fit curve, such as a Gaussian curve, to the water equivalent thickness of the sampled beam path. Repeated measurements as a function of incident angle and/or position of the incident charged particles allows generation of an image of the sample, such as a computed tomography image.

摘要翻译： 本发明包括用于使用带正电荷的微粒探测患者肿瘤的方法和装置，其包括以下步骤：（1）将一系列不同且已知的带正电荷的颗粒顺序递送给患者; （2）通过病人传送后，依次检测各带正电粒子的剩余能量; 和（3）使用与曲线拟合的残余能量的函数的检测器响应的图来确定患者的探测路径的水当量厚度。 分析仪将拟合曲线的半值最大值（例如高斯曲线）与采样光束路径的水当量厚度相关联。 作为入射角度和/或入射带电粒子的位置的函数的重复测量允许产生样本的图像，例如计算机断层摄影图像。

公开(公告)号：US20170036041A1

公开(公告)日：2017-02-09

申请号：US15334206

申请日：2016-10-25

申请人： Lauri Reichert ,  Stephen Sledge ,  Edward Ivanov ,  W. Davis Lee

发明人： Lauri Reichert ,  Stephen Sledge ,  Edward Ivanov ,  W. Davis Lee

IPC分类号： A61N5/10 ,  G21K5/04 ,  G21K1/093 ,  A61B6/03

CPC分类号： A61N5/1077 ,  A61B6/032 ,  A61B6/4092 ,  A61B6/4258 ,  A61B6/4266 ,  A61B6/485 ,  A61B6/487 ,  A61B6/5205 ,  A61N5/1037 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1082 ,  A61N2005/1054 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/08 ,  G21K1/093 ,  G21K5/04

摘要： The invention comprises a method and apparatus for directing charged particles into a patient from several directions. A delivery system is described that uses a primary beam line from an accelerator to a path switching magnet used to dynamically direct bunches of the positively charged particles down a selected pathway of a plurality of physically separated beam transport lines to a single patient treatment position, where the selected pathways enter the patient from two or more sides. Optionally, a repositionable treatment nozzle is repositioned to interface with each beam transport line, which allows the charged particle delivery system to use a single scanning capable nozzle in combination with delivery of the charged particles to the two or more sides of the patient to implement a tumor irradiation plan without a necessity of a moveable beamline in, at, or near a treatment room.

摘要翻译： 本发明包括一种用于将带电粒子从多个方向引导到患者体内的方法和装置。 描述了一种输送系统，其使用来自加速器的主波束线到路径切换磁体，用于将多个物理分离的波束输送线的选定路径的带正电荷的粒子的一束动态地引导到单个患者治疗位置， 选定的路径从两侧或两侧进入患者。 可选地，可重新定位的治疗喷嘴被重新定位以与每个束输送管线相接合，这允许带电粒子输送系统使用单一扫描能力的喷嘴与将带电粒子递送到患者的两侧或更多侧来实现 肿瘤照射计划，而不需要在治疗室内，附近或附近的可移动的束线。

公开(公告)号：US20160339271A1

公开(公告)日：2016-11-24

申请号：US15087800

申请日：2016-03-31

申请人： Varian Medical Systems Particle Therapy GmbH ,  Varian Medical Systems, Inc.

发明人： Markus BACH ,  Isabel HUTH ,  Juergen HEESE ,  Franko PISKULICH ,  Lei DONG

IPC分类号： A61N5/10

CPC分类号： A61N5/1081 ,  A61N5/1037 ,  A61N5/1044 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1068 ,  A61N2005/1087

摘要： To overcome the difficulties inherent in conventional proton therapy systems, new techniques are described herein for synchronizing the application of proton radiation with the periodic movement of a target area. In an embodiment, a method is provided that combines multiple rescans of a spot scanning proton beam while monitoring the periodic motion of the target area, and aligning the applications of the proton beam with parameters of the periodic motion. For example, the direction(s) and frequency of the periodic motion may be monitored, and the timing, dose rate, and/or scanning direction and spot sequence of the beam can be adjusted to align with phases in the periodic motion

摘要翻译： 为了克服常规质子治疗系统中固有的困难，本文描述了用于使质子辐射的应用与目标区域的周期性运动同步的新技术。 在一个实施例中，提供了一种组合点扫描质子束的多个重新扫描的方法，同时监视目标区域的周期性运动，并且将质子束的应用与周期性运动的参数对准。 例如，可以监视周期性运动的方向和频率，并且可以调节光束的定时，剂量率和/或扫描方向和光点顺序以与周期运动中的相位对齐

公开(公告)号：US20160325116A1

公开(公告)日：2016-11-10

申请号：US15110600

申请日：2014-01-10

申请人： MITSUBISHI ELECTRIC CORPORATION

发明人： Yusuke SAKAMOTO ,  Yuehu PU ,  Hisashi HARADA ,  Taizo HONDA

IPC分类号： A61N5/10

CPC分类号： A61N5/1043 ,  A61N5/1044 ,  A61N5/1071 ,  A61N2005/1087

摘要： In a particle beam irradiation apparatus that controls a scanning apparatus so that each irradiation position is irradiated with a particle beam a rescan-count number of times by repeating for the rescan-count number of times the irradiation of all irradiation positions in the irradiation target, the irradiation apparatus includes a calculator that receives either one of a rescan count n or a beam intensity J that is a particle beam dose per unit time, to calculate a maximum value of the other satisfying the following conditional expression (P1) for all irradiation positions to present the maximum value to a user. J*ti≦di/n  (P1)

公开(公告)号：US20160317838A1

公开(公告)日：2016-11-03

申请号：US15207245

申请日：2016-07-11

申请人： Susan L. Michaud ,  Daniel J. Raymond ,  Stephen L. Spotts

发明人： Susan L. Michaud ,  Daniel J. Raymond ,  Stephen L. Spotts

IPC分类号： A61N5/10 ,  A61B6/00 ,  A61B6/03

CPC分类号： A61N5/1081 ,  A61B6/03 ,  A61B6/032 ,  A61B6/4216 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1054 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/08 ,  G21K5/04

摘要： The invention comprises a patient specific tray insert removably inserted into a tray frame to form a beam control tray assembly, which is removably inserted into a slot of a tray receiver assembly proximate a gantry nozzle of a charged particle cancer treatment system. Optionally, multiple tray inserts, each used to control a different beam state parameter, are inserted into corresponding slots of the tray receiver assembly where the multiple inserts are used to control beam intensity, shape, focus, and/or energy. The beam control tray assembling includes an identifier, such as an electromechanical identifier, of the particular insert type, which is communicated to a main controller, such as via the tray receiver assembly along with slot position and/or patient information.

摘要翻译： 本发明包括可移除地插入到托盘框架中的患者特定托盘插入件，以形成束控制托盘组件，其可移除地插入靠近带电粒子癌症治疗系统的门架喷嘴的托盘接收器组件的槽中。 可选地，将用于控制不同波束状态参数的多个托盘插入件插入托盘接收器组件的相应插槽中，其中多个插入件用于控制波束强度，形状，焦点和/或能量。 光束控制托盘组装包括特定插入物类型的诸如机电标识符的标识符，其被传送到主控制器，例如经由托盘接收器组件以及插槽位置和/或患者信息。