公开(公告)号：US20150238713A1

公开(公告)日：2015-08-27

申请号：US14487494

申请日：2014-09-16

申请人： AJ MARKETING LLC

发明人： Scott A. Cohen ,  Michael J. Bedecs

IPC分类号： A61M15/00 ,  A61M15/06 ,  A24F47/00

CPC分类号： A61M15/0066 ,  A24F47/008 ,  A61M11/042 ,  A61M15/008 ,  A61M15/0083 ,  A61M15/0085 ,  A61M15/0091 ,  A61M15/06 ,  A61M2016/0024 ,  A61M2202/0468 ,  A61M2205/123 ,  A61M2205/33 ,  A61M2205/3306 ,  A61M2205/3368 ,  A61M2205/35 ,  A61M2205/502 ,  A61M2205/581 ,  A61M2205/584 ,  A61M2205/587 ,  A61M2205/8206

摘要： A personal inhalation device includes an outer shell having an orifice formed therein and containing a medium having one or more deliverables and an atomizing unit disposed within the shell. The atomizing unit atomizes the medium when a user puffs on the orifice such that vapor containing the deliverables is discharged through the orifice. The personal inhalation device is further capable of metering the deliverables discharged with the vapor.

摘要翻译： 个人吸入装置包括具有形成在其中的孔的外壳，并且包含具有一个或多个可交付物的介质和设置在壳体内的雾化单元。 当用户在孔口上吹动时，雾化单元使介质雾化，使得含有可交付物的蒸气通过孔排出。 个人吸入装置还能够计量用蒸气排出的输送物质。

公开(公告)号：US20150238412A1

公开(公告)日：2015-08-27

申请号：US14699797

申请日：2015-04-29

申请人： MAP Pharmaceuticals, Inc.

发明人： Donald J. Kellerman ,  Shashidhar H. Kori ,  Scott W. Borland ,  Thomas A. Armer

IPC分类号： A61K9/00 ,  A61K31/48

CPC分类号： A61K9/008 ,  A61K31/48 ,  A61M15/002 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0083 ,  A61M15/0086 ,  A61M15/009 ,  A61M2202/064 ,  A61M2205/84 ,  A61M2250/00

摘要： Disclosed are compositions of matter and related methods that provide a metered dose inhaler that includes a formulation having a dose that comprises a hydrofluoroalkane propellant and dihydroergotamine mesylate particles; wherein the dose includes between 0.1 mg to 4 mg of dihydroergotamine mesylate; wherein the dihydroergotamine mesylate particles have a cumulative drug substance particle size distribution with d10>0.5 micron volumetric median diameter and d90

摘要翻译： 公开了提供计量剂量吸入器的物质和相关方法的组合物，其包括具有包含氢氟烷烃推进剂和二氢麦角胺甲磺酸盐颗粒的剂量的制剂; 其中所述剂量包括0.1mg至4mg的甲磺酸二氢麦角胺; 其中所述二氢麦角胺甲磺酸盐颗粒具有d10> 0.5微米体积中值直径和d90 <5.0微米体积中值直径的累积药物物质粒度分布。

公开(公告)号：US09027551B2

公开(公告)日：2015-05-12

申请号：US13734323

申请日：2013-01-04

申请人： Oriel Therapeutics, Inc.

发明人： Michael King ,  Jeffrey Alan Warden ,  Patrick D. Lopath ,  Richard D. LaRoche

IPC分类号： A61M15/00 ,  B01F5/06

CPC分类号： A61M15/0091 ,  A61M15/001 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0083 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/3569 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2206/14 ,  B01F5/0619 ,  B01F2005/0636 ,  Y10T29/49826

摘要： Inhalers with fins that deagglomerate dry powder using inspiratory effort of a user of an inhaler. The inhaler fins, at least in steady state conditions, are configured to generate dry powder and airflow patterns having turbulence with flow vortices, some of which may have a vortex having an axis of rotation that extends in an inspiratory flow direction while others may have a vortex that is substantially orthogonal to the inspiratory flow direction in an inspiratory airflow path, as an amount of dry powder travels through the inhaler to thereby deagglomerate the dry powder without trapping undue amounts of the dry powder during inhalation.

摘要翻译： 具有散热片的吸入器，使用吸入器的使用者的吸气作用解散干粉。 至少在稳态条件下，吸入器散热片被配置成产生具有流动涡流的干燥粉末和气流模式，其中一些流动涡流可具有在吸气流动方向上延伸的具有旋转轴线的涡流，而其他可能具有 随着干粉的数量穿过吸入器，大体上与吸气流动方向垂直的涡流，从而使干燥粉末解体，而不吸入过量的干粉。

公开(公告)号：US20150101599A1

公开(公告)日：2015-04-16

申请号：US14344153

申请日：2012-09-12

申请人： AS-TRAZENECA AB ,  ASTRAZENECA UK LIMITED

发明人： Christopher Simon Berry ,  Jonas Christiansen ,  Svend Erik Elgaard ,  Esben Johansen ,  Claus Schmidt Moller ,  Jorgen Rasmussen ,  William Richard Treneman

IPC分类号： A61M15/00

CPC分类号： A61M15/0075 ,  A61M15/0025 ,  A61M15/0026 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/009 ,  A61M15/0091 ,  A61M15/0096 ,  A61M2205/27 ,  A61M2205/276 ,  A61M2205/585

摘要： An inhaler for delivery of a medicament by inhalation is disclosed. The inhaler comprises a dispensing mechanism, the dispensing mechanism being configured to dispense a dose of medicament on actuation. The inhaler further comprises a dose counting mechanism comprising a counter and a translating member. The translating member comprises a pawl. The counter comprises a first count wheel, a second count wheel and an intermediate wheel engaged with the second count wheel and in selective engagement with the first count wheel. When the inhaler is fired to dispense a dose of medicament, the dispensing mechanism moves the translating member in a substantially linear direction. The pawl thus rotates the first count wheel, and as the first count wheel rotates, the intermediate wheel is selectively engaged thereby selectively rotating the second count wheel to count the doses of the inhaler.

摘要翻译： 公开了用于通过吸入递送药物的吸入器。 吸入器包括分配机构，分配机构构造成在致动时分配剂量的药物。 吸入器还包括剂量计数机构，其包括计数器和平移构件。 平移构件包括棘爪。 计数器包括第一计数轮，第二计数轮和与第二计数轮啮合并与第一计数轮选择性地接合的中间轮。 当吸入器被燃烧以分配一定剂量的药物时，分配机构使平移构件沿基本上线性的方向移动。 棘爪因此旋转第一计数轮，并且当第一计数轮旋转时，中间轮选择性地接合，从而选择性地旋转第二计数轮以计数吸入器的剂量。

公开(公告)号：US20150061867A1

公开(公告)日：2015-03-05

申请号：US14470240

申请日：2014-08-27

申请人： Gecko Health Innovations, Inc.

发明人： Yechiel Engelhard ,  Mark Maalouf

IPC分类号： G08B21/18 ,  G08B21/02

CPC分类号： G08B21/24 ,  A61J7/0418 ,  A61J7/0436 ,  A61J7/0481 ,  A61J2200/30 ,  A61J2200/70 ,  A61M15/008 ,  A61M15/009 ,  A61M2205/332 ,  A61M2205/3331 ,  A61M2205/3393 ,  A61M2205/3553 ,  A61M2205/3576 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/587 ,  A61M2205/8206 ,  G06F19/00 ,  G06F19/3462 ,  G06Q50/24

摘要： Devices, systems, and methods are provided for adherence monitoring, and devices, systems, and methods are provided for monitoring use of consumable dispensers. In general, the devices, systems, and methods can facilitate an individual's adherence to a schedule for consuming consumables and can facilitate monitoring and tracking of the individual's adherence to the schedule. The devices, systems, and methods can allow data regarding the individual's historical adherence to the schedule to be accessible via a computer system. In one embodiment, an accessory is provided that can be configured to attach to consumable dispensers. The accessory can be configured to be removably and replaceably coupled to the dispenser. The accessory can be configured to provide a notification to a user indicating that a certain event occurred and/or that a certain action needs to be taken. The accessory can be configured to sense attachment thereof to and removal thereof from the dispenser.

摘要翻译： 提供设备，系统和方法用于遵守监控，并提供设备，系统和方法来监控消耗式分配器的使用。 通常，设备，系统和方法可以促进个人遵守消耗耗材的时间表，并且可以促进对个体遵守时间表的监视和跟踪。 设备，系统和方法可以允许关于个人历史遵守时间表的数据可以通过计算机系统访问。 在一个实施例中，提供了可配置成附接到消耗式分配器的附件。 附件可以被配置为可移除地和可替代地耦合到分配器。 配件可以被配置为向用户提供指示某个事件发生的通知和/或需要采取某些动作。 附件可以被配置成感测其附着并从分配器移除。

公开(公告)号：US08944055B2

公开(公告)日：2015-02-03

申请号：US12864339

申请日：2009-01-22

申请人： Graham Gibbins ,  Ben Tyers ,  Andreas Mark Meliniotis

发明人： Graham Gibbins ,  Ben Tyers ,  Andreas Mark Meliniotis

IPC分类号： A61M15/00 ,  A61M16/00 ,  A61M11/00 ,  B05B1/26 ,  A62B7/00 ,  A62B9/00

CPC分类号： A61M15/0045 ,  A61M15/0021 ,  A61M15/0025 ,  A61M15/0033 ,  A61M15/0036 ,  A61M15/0041 ,  A61M15/0051 ,  A61M15/008 ,  A61M2202/064

摘要： An inhaler is disclosed. It comprises a housing to receive a strip having a surface and a plurality of blister pockets depending from said surface. Each blister pocket contains a dose of medicament for inhalation by a user. The inhaler has a blister strip drive mechanism including a blister strip drive member shaped to contact the strip along a line defined by the crease between a blister pocket and said surface, to drive said strip.

摘要翻译： 公开了一种吸入器。 它包括用于接收具有表面的条带的壳体和从所述表面悬垂的多个泡罩袋。 每个泡罩袋包含一定剂量的用于用户吸入的药物。 吸入器具有泡罩带驱动机构，其包括泡罩条驱动构件，其形状为沿着由泡罩袋和所述表面之间的折痕限定的线接触条带，以驱动所述条带。

公开(公告)号：US08800819B2

公开(公告)日：2014-08-12

申请号：US13200682

申请日：2011-09-28

申请人： Silvio Carriço ,  Michael Helmlinger ,  Joerg Kohnle

发明人： Silvio Carriço ,  Michael Helmlinger ,  Joerg Kohnle

IPC分类号： B05B12/02 ,  A61M15/00 ,  A61M15/08 ,  B05B11/00

CPC分类号： A61M15/0065 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0083 ,  A61M15/08 ,  A61M2205/3317 ,  A61M2205/502 ,  A61M2205/6054 ,  B05B11/3059

摘要： A discharging device for dispensing liquids having a housing, control electronics, a liquid storage receptacle, a discharge orifice, a conveying device actuable manually by a first actuator which transports the liquid to the discharge orifice from the storage receptacle and a blocking device, which in a blocked state blocks the actuation of the conveying device and in a released state allows actuation of the conveying device. The blocking device includes an interlock device movable relative to the housing between first and second positions and a movement of the interlock device from the first to the second position causes the blocking device to assume the released state. The interlock device is biased by a spring device in the direction of the second position and a first retaining device is provided which retains the interlock device in the first position and which is releasable by a signal from the control electronics.

摘要翻译： 一种用于分配液体的排出装置，具有壳体，控制电子装置，液体存储容器，排出孔，由第一致动器手动地致动的输送装置，该第一致动器将液体从储存容器输送到排出孔，以及阻塞装置， 阻塞状态阻止输送装置的致动，并且在释放状态允许驱动输送装置。 阻挡装置包括可在第一和第二位置之间相对于壳体移动的互锁装置，并且联锁装置从第一位置到第二位置的运动使阻挡装置处于释放状态。 互锁装置由弹簧装置沿第二位置的方向偏置，并且提供第一保持装置，其将互锁装置保持在第一位置，并且可通过来自控制电子装置的信号释放。

公开(公告)号：US08800559B2

公开(公告)日：2014-08-12

申请号：US13450804

申请日：2012-04-19

申请人： Nicholas Bowman ,  Jörgen Fruensgaard ,  Jörgen Funder Rasmussen ,  Henrik Hougaard Vilstrup ,  Keld Sloth Christensen

发明人： Nicholas Bowman ,  Jörgen Fruensgaard ,  Jörgen Funder Rasmussen ,  Henrik Hougaard Vilstrup ,  Keld Sloth Christensen

IPC分类号： A61M11/00

CPC分类号： A61M15/0091 ,  A61M15/0025 ,  A61M15/0026 ,  A61M15/007 ,  A61M15/0071 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0086 ,  A61M15/009 ,  A61M15/0095 ,  A61M15/0096 ,  A61M2205/6072 ,  A61M2205/6081

摘要： The disclosure relates to an Breath actuated inhaler (BAI) actuator, comprising: a loading element capable of being loaded with an actuation force, a breath actuated trigger mechanism arranged to counteract the actuation force of the loading element, and to fire the actuator by releasing the actuation force of the loading element in response to an inhalation breath, and actuation locking device moveable between a locked position wherein it relieves the actuation force from the trigger mechanism setting the trigger mechanism in a neutral position, and an armed position wherein the trigger mechanism is set in an armed position.

摘要翻译： 本发明涉及一种呼吸致动吸入器（BAI）致动器，包括：能够加载致动力的加载元件，被配置为抵消加载元件的致动力的呼吸致动触发器机构，并且通过释放来致动致动器 负载元件响应于吸入呼吸的致动力，以及致动锁定装置，其可在锁定位置之间移动，在锁定位置，其中释放来自将触发机构设置在中立位置的触发机构的致动力，以及布置位置，其中触发机构 被置于武装地位。

公开(公告)号：US20140187969A1

公开(公告)日：2014-07-03

申请号：US14200268

申请日：2014-03-07

申请人： Corinthian Ophthalmic, Inc.

发明人： Charles Eric HUNTER ,  Bernard L. BALLOU, JR. ,  Jurgen Klaus VOLLRATH ,  Arthur H. TEW ,  Joshua Richard BROWN ,  James Thornhill LEATH ,  Nathan R. FAULKS ,  Bradley G. JOHNSON ,  J. Sid CLEMENTS ,  Phillip E. RUSSELL ,  John H. HEBRANK ,  Tsontcho INACHULEV ,  Mark PACKER ,  Troy ELLIOTT ,  Walter M. FIERSON ,  Thomas J. LINDNER

IPC分类号： A61F9/00 ,  A61B5/00

CPC分类号： A61F9/0008 ,  A61B5/0059 ,  A61B5/4839 ,  A61M15/008 ,  A61M15/0083 ,  A61M15/025 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G16H10/60 ,  G16H15/00 ,  G16H40/63

摘要： A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.

摘要翻译： 将用于局部，口服，鼻腔或肺部使用的安全，合适和可重复的剂量递送到受试者的方法和用于液滴喷射的装置包括能够以液滴形式输送限定体积的液体的流体输送系统， 在施用时提供足够和可重复的高百分比沉积的性质。 所述方法和装置包括壳体，设置在壳体内用于接收一定体积的流体的储存器;喷射器机构，其构造成喷射具有大于15微米的平均喷射液滴直径的液滴流，所述液滴流具有低夹带气流 使得在使用期间液滴流沉积在受试者的眼睛上。

公开(公告)号：US20140182584A1

公开(公告)日：2014-07-03

申请号：US14129257

申请日：2012-09-20

申请人： NEXUS6 LIMITED

发明人： Garth Campbell Sutherland ,  Michael James Gormack

IPC分类号： A61M15/00

CPC分类号： A61M15/008 ,  A61M15/0071 ,  A61M15/009 ,  A61M2205/3368 ,  A61M2205/3561 ,  A61M2205/3592 ,  A61M2205/6063 ,  A61M2230/50

摘要： This invention relates to a compliance monitor for monitoring patient usage of a medicament delivery device, where the medicament delivery device includes a store of medicament and a medicament dispensing means. The compliance monitor includes a housing adapted to enclose the medicament delivery device, and a dose counter, associated with the housing, for recording the delivery of a dose of medicament to the patient from the medicament delivery device. The arrangement and construction is such that the housing is loosely coupled to the medicament delivery device, whereby the housing is able to move relative to the medicament delivery device during the delivery of the dose of medicament, and it is this movement which actuates the dose counter, either directly or indirectly, in order to record the delivery of the dose of medicament.

摘要翻译： 本发明涉及用于监测药物输送装置的患者使用的顺应性监测器，其中药物输送装置包括药物储存和药物分配装置。 合规监测器包括适于封闭药物输送装置的壳体和与壳体相关联的剂量计数器，用于记录从药物输送装置向患者输送一定剂量的药物。 布置和结构使得外壳松散地联接到药物输送装置，由此在输送剂量的药物期间，壳体能够相对于药物输送装置移动，并且正是这种动作来驱动剂量计数器 直接或间接地，以记录药物剂量的递送。