公开(公告)号：US20040009553A1

公开(公告)日：2004-01-15

申请号：US10426776

申请日：2003-04-30

申请人： Millennium Pharmaceuticals, Inc.

发明人： Maria A. Glucksmann ,  Mark J. Williamson ,  Fong-Ying Tsai ,  Laura A. Rudolph-Owen ,  Rosanna Kapeller-Libermann ,  Rachel E. Meyers ,  Lillian Wei-Ming Chiang ,  John Joseph Hunter

IPC分类号： C12P021/02 ,  C12N005/06 ,  C07K014/705 ,  C07H021/04

CPC分类号： C12N9/1288 ,  A01K2217/05 ,  A61K38/00 ,  A61K47/6805 ,  A61K47/6809 ,  A61K47/6821 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/4747 ,  C07K2319/00 ,  C12N9/14 ,  C12N9/16 ,  C12N9/6472 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57484 ,  G01N2500/10

摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC 17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4， NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B ，NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。 本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体 到蛋白质。 还提供了利用本发明组合物的诊断和治疗方法。