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61 条记录 (耗时 0.03 秒)

    Detection and quantification of abasic site formation in vivo
    41.
    发明授权
    Detection and quantification of abasic site formation in vivo 有权
    体内无碱基位点形成的检测和定量

    公开(公告)号：US08367332B2

    公开(公告)日：2013-02-05

    申请号：US12610871

    申请日：2009-11-02

    申请人： Lili Liu ,  Yanming Wang ,  Stanton Gerson

    发明人： Lili Liu ,  Yanming Wang ,  Stanton Gerson

    IPC分类号： C12Q1/68 ,  C07H21/00

    CPC分类号： A61K51/0406 ,  A61K49/0008 ,  G01N33/5011

    摘要： A method of measuring the efficacy of an anticancer agent in generating abasic (AP) sites in DNA of cancer cells of a subject includes administering to the subject an anticancer agent that generates AP sites in at least one cancer cell and an AP endonuclease inhibitor probe. The AP endonuclease inhibitor probe includes a detection moiety for detecting the probe in the subject. The amount of probe bound to cancer cells of the subject is then measured. The amount of probe bound to cancer cells of the subject is indicative of efficacy of the anticancer agent in generating AP sites in cancer cells of the subject.

    摘要翻译： 测量抗癌剂在产生受试者的癌细胞的DNA中的脱碱性（AP）位点的功效的方法包括向受试者施用在至少一种癌细胞中产生AP位点的抗癌剂和AP内切核酸酶抑制剂探针。 AP内切核酸酶抑制剂探针包括用于检测受试者中的探针的检测部分。 然后测量与受试者的癌细胞结合的探针的量。 与受试者的癌细胞结合的探针的量指示抗癌剂在产生受试者的癌细胞中的AP位点的功效。

    ROUNDTRIP MERGE OF BPEL PROCESSES AND BPMN MODELS
    43.
    发明申请
    ROUNDTRIP MERGE OF BPEL PROCESSES AND BPMN MODELS 有权
    BPEL流程和BPMN模型的ROUNDTRIP MERGE

    公开(公告)号：US20100057482A1

    公开(公告)日：2010-03-04

    申请号：US12200762

    申请日：2008-08-28

    申请人： Ganesh Radhakrishnan ,  Lili Liu ,  Anurag Aggarwal ,  Vishal Saxena

    发明人： Ganesh Radhakrishnan ,  Lili Liu ,  Anurag Aggarwal ,  Vishal Saxena

    IPC分类号： G06Q99/00

    CPC分类号： G06Q10/06 ,  G06Q10/067

    摘要： In one embodiment, a method of performing a merge operation can include: mapping a business process modeling notation (BPMN) model to a business process execution language (BPEL) model; modifying the BPMN model to form a modified BPMN model; modifying the BPEL model to form a modified BPEL model; when the merge operation is a forward merge operation: exporting the modified BPMN model to an exported BPEL model; performing an activity level outline merge for added information technology (IT) scopes and branches from the modified BPEL model; performing an activity level detail merge for added IT details from the modified BPEL model; and performing an attribute level merge for updated branch conditions in the merged BPEL model; and when the merge operation is a reverse merge operation, adding scopes and branches from the modified BPEL model to the BPMN model.

    摘要翻译： 在一个实施例中，执行合并操作的方法可以包括：将业务流程建模符号（BPMN）模型映射到业务流程执行语言（BPEL）模型; 修改BPMN模型以形成修改的BPMN模型; 修改BPEL模型以形成修改的BPEL模型; 当合并操作是前向合并操作时：将修改的BPMN模型导出到导出的BPEL模型; 从修改的BPEL模型执行附加信息技术（IT）范围和分支的活动级别大纲合并; 执行活动级详细信息合并，以从修改的BPEL模型中添加IT细节; 以及对所合并的BPEL模型中的更新的分支条件执行属性级合并; 并且当合并操作是反向合并操作时，将修改的BPEL模型中的范围和分支添加到BPMN模型。

    Cardiac stimulation at high ventricular wall stress areas
    45.
    发明申请
    Cardiac stimulation at high ventricular wall stress areas 有权
    心室刺激在高心室壁应激区域

    公开(公告)号：US20050065568A1

    公开(公告)日：2005-03-24

    申请号：US10952346

    申请日：2004-09-28

    申请人： Lili Liu ,  Rodney Salo

    发明人： Lili Liu ,  Rodney Salo

    IPC分类号： A61N1/368 ,  A61N1/365

    CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

    摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

    摘要翻译： 用电刺激治疗逆转心室重构的装置和方法。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

    Telecommunication intelligent card and method for signaling interaction with external non-contact card
    48.
    发明授权
    Telecommunication intelligent card and method for signaling interaction with external non-contact card 有权
    电信智能卡和信号与外部非接触卡互动的方法

    公开(公告)号：US08594570B2

    公开(公告)日：2013-11-26

    申请号：US12865676

    申请日：2009-01-14

    申请人： Guangwen Yan ,  Lili Liu

    发明人： Guangwen Yan ,  Lili Liu

    IPC分类号： H04B7/00

    CPC分类号： G06K19/07

    摘要： A telecommunication intelligent card and a method for signaling interaction between a telecommunication intelligent card and an external non-contact card. The telecommunication intelligent card includes: a control unit for controlling a transmission unit to perform interactive communication with an external non-contact card, and processing signaling data from the transmission unit; and a transmission unit for interactive communication with the external non-contact card, and transmitting the signaling data received from the external non-contact card to the control unit.

    摘要翻译： 电信智能卡和用于信令电信智能卡与外部非接触卡之间的交互的方法。 电信智能卡包括：控制单元，用于控制传输单元执行与外部非接触卡的交互式通信，以及处理来自传输单元的信令数据; 以及与外部非接触卡进行交互式通信的发送单元，将从外部非接触卡接收到的信令数据发送到控制单元。

    System and method for pacing rate control utilizing patient hemodynamic status information
    49.
    发明授权
    System and method for pacing rate control utilizing patient hemodynamic status information 有权
    使用患者血液动力学状态信息进行起搏速率控制的系统和方法

    公开(公告)号：US08417336B2

    公开(公告)日：2013-04-09

    申请号：US12787868

    申请日：2010-05-26

    申请人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

    发明人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36564 ,  A61N1/36542 ,  A61N1/36585

    摘要： A system and method for pacing rate control in a cardiac rhythm management (CRM) system. The method includes acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient and generating a CVP waveform from the pressure signal. A pacing stimulus is applied to the patient's heart, and the pacing rate is increased in response to increases in patient's metabolic demand. The CVP index is monitored during the pacing rate increase, and the CRM system detects a reduction in the patient's hemodynamic performance based on the CVP index and establishes a maximum rate setting based on the pacing rate corresponding to the reduction in the patient's hemodynamic performance.

    摘要翻译： 用于心律管理（CRM）系统中起搏速率控制的系统和方法。 该方法包括从植入患者冠状静脉内的压力传感器获取代表冠状静脉压（CVP）的压力信号，并从压力信号产生CVP波形。 对患者的心脏施加起搏刺激，并且响应于患者代谢需求的增加而起搏速率增加。 在起搏速率增加期间监测CVP指数，并且CRM系统基于CVP指数检测患者血液动力学性能的降低，并且基于与患者血液动力学性能的降低相对应的起搏速率来建立最大速率设定。