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41.发明申请2-Acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof 失效2-酰基氨基-4-苯基噻唑衍生物，其制备及其治疗应用公开(公告)号：US20060135575A1
公开(公告)日：2006-06-22
申请号：US11253998
申请日：2005-10-19
申请人： Pierre Carayon , Pierre Casellas , Daniel Floutard , Pierre Fraisse , Samir Jegham , Bernard Labeeuw
发明人： Pierre Carayon , Pierre Casellas , Daniel Floutard , Pierre Fraisse , Samir Jegham , Bernard Labeeuw
IPC分类号： C07D277/18 , A61K31/426
CPC分类号： C07D401/04 , C07D277/46 , C07D405/12 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/08
摘要： The invention relates to 2-acylamino-4-phenylthiazole derivatives of general formula (I): pharmaceutically acceptable acid-addition salts thereof, hydrates or solvates of such derivatives or such pharmaceutically acceptable acid addition salts, intermediates thereto, processes for the preparation thereof, and therapeutic application thereof.
摘要翻译： 本发明涉及通式（I）的2-酰基氨基-4-苯基噻唑衍生物：其药学上可接受的酸加成盐，该衍生物的水合物或溶剂合物或其药学上可接受的酸加成盐，其中间体，其制备方法， 及其治疗应用。
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42.发明申请公开(公告)号：US20050004132A1
公开(公告)日：2005-01-06
申请号：US10495890
申请日：2002-11-18
申请人： Marco Baroni , Bernard Bourrie , Pierre Casellas , Letizia Puleo
发明人： Marco Baroni , Bernard Bourrie , Pierre Casellas , Letizia Puleo
IPC分类号： C07D401/08 , A61K31/4545 , A61K31/497 , A61P1/00 , A61P3/10 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/02 , A61P35/00 , A61P37/02 , A61P43/00 , C07D401/10 , C07D401/14 , C07D403/08 , A61K31/506 , A61K31/444 , C07
CPC分类号： C07D401/10
摘要： This invention relates to nitrogenous (tetrahydropyridyl)(alkyl)heterocycles, to pharmaceutical compositions comprising them, to processes for preparing them and to the method of use thereof in the treatment of pain and diseases related to immune and inflammatory disorders.
摘要翻译： 本发明涉及含氮（四氢吡啶基）（烷基）杂环，包含它们的药物组合物，其制备方法及其用于治疗与免疫和炎性疾病相关的疼痛和疾病的方法。
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43.发明授权Phenyl- and pyridyl-tetrahydro-pyridines having TNF inhibiting activity 有权具有TNF抑制活性的苯基 - 和吡啶基 - 四氢 - 吡啶公开(公告)号：US06509351B1
公开(公告)日：2003-01-21
申请号：US10111045
申请日：2002-04-19
IPC分类号： C07D40106
CPC分类号： C07D401/06 , A43B7/125 , A43B9/02 , B29C2045/14844 , B29D35/0045 , B29D35/06 , B29D35/062 , B29D35/122 , B29D35/128 , B29D35/142 , C07D215/14 , C07D217/02 , C07D401/14
摘要： The present invention relates to compounds of formula (I): as well as the salts or solvates thereof, to pharmaceutical compositions containing them, to a process for preparing them and to synthetic intermediates in this process.
摘要翻译： 本发明涉及式（I）化合物：以及其盐或溶剂合物，含有它们的药物组合物，其制备方法和该方法中的合成中间体。
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44.发明授权Benzene derivatives, preparation method and pharmaceutical compositions containing same 有权苯衍生物，制备方法和含有它们的药物组合物公开(公告)号：US06482986B1
公开(公告)日：2002-11-19
申请号：US10009140
申请日：2002-02-27
申请人： Robert Boigegrain , Bernard Bourrie , Martine Bourrie , Pierre Casellas , Jean Marc Herbert , Pierre Lair , Dino Nisato , Raymond Paul , Jean Claude Vernieres
发明人： Robert Boigegrain , Bernard Bourrie , Martine Bourrie , Pierre Casellas , Jean Marc Herbert , Pierre Lair , Dino Nisato , Raymond Paul , Jean Claude Vernieres
IPC分类号： C07C21100
CPC分类号： C07C211/40 , C07C2601/14 , C07C2603/74
摘要： The invention concerns compounds of formula (I) wherein A, X, Y, n, R1, R2 and R3 are as defined in claim 1. Said compounds are specifically binding to sigma receptors particularly those of the peripheral nervous system.
摘要翻译： 本发明涉及式（I）化合物，其中A，X，Y，n，R 1，R 2和R 3如权利要求1中所定义。所述化合物特异性结合σ受体，特别是外周神经系统的受体。
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45.发明授权Pyrazole derivatives, method of preparing them and pharmaceutical compositions in which they are present 失效吡唑衍生物，其制备方法和它们存在的药物组合物
公开(公告)号：US5624941A
公开(公告)日：1997-04-29
申请号：US348881
申请日：1994-11-29
申请人： Francis Barth , Pierre Casellas , Christian Congy , Serge Martinez , Murielle Rinaldi , Gilles Anne-Archard
发明人： Francis Barth , Pierre Casellas , Christian Congy , Serge Martinez , Murielle Rinaldi , Gilles Anne-Archard
IPC分类号： A61K31/415 , A61K31/4155 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/5375 , A61K31/553 , A61P1/08 , A61P9/00 , A61P9/10 , A61P11/06 , A61P11/08 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/06 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D20060101 , C07D231/12 , C07D231/14 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D493/08
CPC分类号： C07D231/12 , C07D231/14 , C07D231/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D493/08
摘要： The present invention relates to compounds of the formula: ##STR1## These compounds are useful in pharmaceuticals in which cannabis is known to be involved.
摘要翻译： 本发明涉及下式的化合物：（I）这些化合物可用于已知涉及大麻的药物中。
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46.发明授权Ribosome-inactivating glycoproteins, modified by oxidation of their osidic units and reduction, and in vivo prolonged-action immunotoxins containing such a glycoprotein 失效通过氧化其功能单位和减少修饰的糖蛋白 - 灭活性糖蛋白，以及含有这种糖蛋白的体内促进作用的免疫调节蛋白
公开(公告)号：US5106956A
公开(公告)日：1992-04-21
申请号：US404611
申请日：1989-09-08
申请人： Pierre Casellas , Bernard Bourrie , Xavier Canat
发明人： Pierre Casellas , Bernard Bourrie , Xavier Canat
IPC分类号： C07K14/00 , A61K36/00 , A61K36/18 , A61K36/42 , A61K36/896 , A61K38/00 , A61K38/36 , A61K39/395 , A61K47/48 , C07K1/107 , C07K1/113 , C07K14/415 , C07K14/42 , C07K19/00
CPC分类号： C07K14/415 , A61K47/48469 , A61K47/48476 , C07K1/107 , A61K38/00 , Y10S530/863 , Y10S530/866
摘要： Glycoprotein which inactivates ribosomes (GPIR) having the ribosome-inhibiting activity of the native GPIR and having a prolonged-action in vivo which is obtained by oxidation of its osidic units by the action of periodate ions, and simultaneous reduction with cyanoborohydride ions. Said modified glycoprotein may be coupled to an antibody or a fragment thereof in order to form an immunotoxin having a prolonged-action in vivo.
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47.发明授权Ribosome-inactivating glycoproteins, modified by oxidation of their osidic units and formation of a Schiff's base and in-vivo prolonged action immunotoxins containing such a glycoprotein 失效RIBOSOME-灭活GLYCOPROTEIN，其通过氧化其功能单元和形成SCHIFF的基础和体内促进的作用修饰的含有这种糖蛋白的免疫原性
公开(公告)号：US5104976A
公开(公告)日：1992-04-14
申请号：US404052
申请日：1989-09-08
申请人： Pierre Casellas , Bernard Bourrie , Xavier Canat
发明人： Pierre Casellas , Bernard Bourrie , Xavier Canat
IPC分类号： C07K14/00 , A61K36/00 , A61K36/18 , A61K36/42 , A61K36/896 , A61K38/00 , A61K38/36 , A61K39/395 , A61K47/48 , A61P35/00 , C07K1/107 , C07K1/113 , C07K14/415 , C07K14/42 , C07K19/00
CPC分类号： A61K47/48469 , A61K47/48476 , A61K47/48715 , C07K1/1072 , C07K1/1077 , C07K14/415 , A61K38/00 , Y10S530/863
摘要： Glycoprotein which inactivates ribosomes (GPIR) the ribosome-inhibiting activity of the native GPIR and having a prolonged-action in vivo which is obtained by oxidation of its osidic units by the action of periodate ions, and simultaneous blocking of the oxidation product by formation of a Schiff's base with a suitable primary amine. Said modified glycoprotein may be coupled to an antibody or a fragment thereof in order to form an immunotoxin.
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48.发明授权Pharmaceutical composition comprising a combination of at least one immunotoxin and at least one mannose-containing polymer 失效药物组合物，其包含至少一种免疫毒素和至少一种含甘露糖的聚合物的组合
公开(公告)号：US4749566A
公开(公告)日：1988-06-07
申请号：US801843
申请日：1985-11-26
申请人： Pierre Casellas , Bernard Bourrie , Pierre Gros
发明人： Pierre Casellas , Bernard Bourrie , Pierre Gros
IPC分类号： A61K39/395 , A61K45/00 , A61P35/00 , A61P37/00
CPC分类号： A61K39/395 , Y10S435/81 , Y10S514/885
摘要： The invention relates to pharmaceutical compositions comprising a combination of at least one immunotoxin and at least one mannose-containing polymer. This combination makes it possible to inhibit the rapid elimination of immunotoxins from the plasma after injection.
摘要翻译： 本发明涉及包含至少一种免疫毒素和至少一种含甘露糖的聚合物的组合的药物组合物。 这种组合使得可以抑制注射后等离子体的免疫毒素的快速消除。
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49.发明授权Anti-cancer drugs for the treatment of leukaemias I, constituted by the chain A of ricin and a specific monoclanal antibody 失效用于治疗白血病I的抗癌药物，由蓖麻毒蛋白A链和特异性单核苷酸抗体构成
公开(公告)号：US4643895A
公开(公告)日：1987-02-17
申请号：US438037
申请日：1982-11-01
申请人： Pierre Casellas , Pierre Gros , Franz Jansen
发明人： Pierre Casellas , Pierre Gros , Franz Jansen
CPC分类号： C07K16/3061 , A61K47/48476 , A61K47/4863 , A61K38/00 , Y10S514/885 , Y10S530/866
摘要： The present invention relates to an anti-cancer drug, characterized in that it contains at least one product constituted by the chain A of recin conjugated by means of a disulfide bridge with at least one fraction of a monoclonal antibody of leukaemic anti-cell specificity, and to the processes for preparing the active ingredient of said drug.
摘要翻译： 本发明涉及一种抗癌药物，其特征在于，其含有至少一种由连接于链的A组成的产物，所述产物通过二硫键与至少一部分白血病抗细胞特异性单克隆抗体结合， 以及制备所述药物的活性成分的方法。
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50.发明授权6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof 失效6-杂芳基吡啶并吲哚酮衍生物，其制备和治疗用途公开(公告)号：US08063061B2
公开(公告)日：2011-11-22
申请号：US12100079
申请日：2008-04-09
申请人： Yvette Muneaux , Samir Jegham , Bernard Bourrie , Pierre Casellas , Paola Ciapetti , Jean-Marie Deroco , Camille-Georges Wermuth
发明人： Yvette Muneaux , Samir Jegham , Bernard Bourrie , Pierre Casellas , Paola Ciapetti , Jean-Marie Deroco , Camille-Georges Wermuth
IPC分类号： A61K31/44 , C07D471/04
CPC分类号： C07D471/04
摘要： The disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, are R5 are as defined in the disclosure; their preparation method, compositions containing the same and therapeutic use thereof.
摘要翻译： 本公开涉及式（I）的化合物：其中R1，R2，R3，R4是R5如本公开中所定义; 它们的制备方法，含有其的组合物和治疗用途。
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